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Association of matrix metalloproteinase 3 and γ-glutamyltransferase 1 gene polymorphisms with the cardio-ankle vascular index in young Russians

Published online by Cambridge University Press:  10 May 2016

Alexander V. Sorokin ,
Kazuhiko Kotani  and
Olga Y. Bushueva
Alexander V. Sorokin*
Affiliation:
Department of Internal Medicine, Kursk State Medical University, Kursk, Russia
Kazuhiko Kotani
Affiliation:
Division of Community and Family Medicine, Jichi Medical University, Tochigi, Japan
Olga Y. Bushueva
Affiliation:
Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russia
*
Correspondence to: A. Sorokin, MD, PhD, Department of Internal Medicine, Kursk State Medical University, K. Marx St.3, 305041, Kursk, Russia. Tel: +7 (4712) 58 8132; Fax: +7 (4712) 56 7399; E-mail: drsorokin@hotmail.com
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Abstract

Specific gene polymorphisms are known to be associated with a different arterial physiology in the younger generation. The present study found that young Russians with the matrix metalloproteinase 3 6A/6A and γ-glutamyltransferase 1AA genotypes have lower levels of the cardio-ankle vascular index – a recent measure of arterial stiffness. This observation may serve as an additional tool for cardiovascular disease prevention in the young population.

Keywords

Arterial stiffnesscardio-ankle vascular indexmatrix metalloproteinasestromelysin-1γ-glutamyltransferasepolymorphism
Type
Brief Reports
Information
Cardiology in the Young , Volume 26 , Issue 6 , August 2016 , pp. 1238 - 1240
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Copyright
© Cambridge University Press 2016 

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