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Are children with protein-losing enteropathy after the Fontan operation at increased risk of cytomegalovirus enteropathy? A report of two cases

Published online by Cambridge University Press:  24 January 2020

Christoph Bauer*
Affiliation:
Department for Pediatric Cardiology, Kepler University Hospital GmbH, Johannes Kepler University Linz, Linz, Austria
Gerald Tulzer
Affiliation:
Department for Pediatric Cardiology, Kepler University Hospital GmbH, Johannes Kepler University Linz, Linz, Austria
*
Author for correspondence: C. Bauer, Department for Pediatric Cardiology, Kepler University Hospital GmbH, Johannes Kepler University Linz, 4020Linz, Austria. Tel: 00435768084/28422. E-mail: christoph.bauer@kepleruniklinikum.at

Abstract

Introduction:

Aetiology of protein-losing enteropathy in single-ventricle type CHD is multi-factorial.

Report:

We describe two Fontan patients with protein-losing enteropathy who presented with cytomegalovirus-associated colitis.

Discussion:

Fontan patients display risk factors for cytomegalovirus-induced gastroenteropathy that may affect lymph angiogenesis, disease development, and progression.

Conclusion:

Cytomegalovirus enteropathy may be common among Fontan patients who suffer from protein-losing enteropathy. Polymerase chain reaction is important for detection.

Type
Brief Report
Copyright
© Cambridge University Press 2020

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References

Rychik, J, Atz, AM, Celermajer, DS, et al.Evaluation and Management of the Child and Adult With Fontan Circulation: A Scientific Statement From the American Heart Association. Circulation [Internet]. Juli 2019 [zitiert 30. Juli 2019]; Verfügbar unter: https://www.ahajournals.org/doi/10.1161/CIR.0000000000000696Google Scholar
Biko, DM, Smith, CL, Otero, HJet al.Intrahepatic dynamic contrast MR lymphangiography: initial experience with a new technique for the assessment of liver lymphatics. Eur Radiol 2019; 29(10), 51905196. doi: 10.1007/s00330-019-06112-z.CrossRefGoogle ScholarPubMed
Voigt, S, Schaffrath Rosario, A, Mankertz, A.Cytomegalovirus seroprevalence among children and adolescents in Germany: Data from the German health interview and examination survey for children and adolescents (KiGGS), 2003–2006. Open Forum Infect Dis. 2016; 3(1), ofv193.CrossRefGoogle ScholarPubMed
Megged, O, Schlesinger, Y.Cytomegalovirus-associated protein-losing gastropathy in childhood. Eur J Pediatr 2008; 167(11), 12171220.CrossRefGoogle ScholarPubMed
Ko, J-H, Peck, KR, Lee, WJ, et al.Clinical presentation and risk factors for cytomegalovirus colitis in immunocompetent adult patients. Clin Infect Dis 2015; 60(6), e2026.CrossRefGoogle ScholarPubMed
Adler, SP, Baggett, J, Mcvoy, M.Transfusion-associated cytomegalovirus infections in seropositive cardiac surgery patients. The Lancet 1985; 326(8458), 743746.CrossRefGoogle Scholar
Shimizu, T, Nagata, S, Fujii, T, et al.Enhanced production of interferon-gamma as a possible cause of protein-losing enteropathy after modified Fontan operation. J Pediatr Gastroenterol Nutr 2003; 37(4), 504507.CrossRefGoogle ScholarPubMed
Soderberg-Naucler, C.Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? J Intern Med 2006; 259(3), 219246.CrossRefGoogle ScholarPubMed
Ukarapol, N, Chartapisak, W, Lertprasertsuk, N, et al.Cytomegalovirus-associated manifestations involving the digestive tract in children with human immunodeficiency virus infection. J Pediatr Gastroenterol Nutr 2002; 35(5), 669673.CrossRefGoogle ScholarPubMed
Cakir, M, Ersoz, S, Akbulut, UE.Disseminated cytomegalovirus infection and protein losing enteropathy as presenting feature of pediatric patient with Crohn’s disease. Pediatr Gastroenterol Hepatol Nutr 2015; 18(1), 6065.CrossRefGoogle ScholarPubMed
Fiorentini, S, Luganini, A, Dell’Oste, V, et al.Human cytomegalovirus productively infects lymphatic endothelial cells and induces a secretome that promotes angiogenesis and lymphangiogenesis through interleukin-6 and granulocyte-macrophage colony-stimulating factor. J Gen Virol 2011; 92(Pt 3), 650660.CrossRefGoogle ScholarPubMed
Siciliano, RF, Castelli, JB, Randi, BA, Vieira, RD, Strabelli, TM. Cytomegalovirus colitis in immunocompetent critically ill patients. Int J Infect Dis 2014; 20, 7173. doi: 10.1016/j.ijid.2013.11.008.CrossRefGoogle ScholarPubMed