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Anakinra as rescue therapy for steroid-dependent idiopathic recurrent pericarditis in children: case report and literature review

  • Moises Rodriguez-Gonzalez (a1), Estefania Ruiz-Gonzalez (a2) and Ana Castellano-Martinez (a3)

Abstract

In approximately 5% of patients with idiopathic recurrent pericarditis, the disease usually follows a chronic relapsing course, and children can develop dependence and side effects of prolonged high-dose corticosteroid regimens. In this setting anakinra, a recombinant human interleukin-1 competitive receptor antagonist that blocks the biologic effects of interleukin-1, thereby reducing systemic inflammatory responses, appears to be one of the most promising strategies. We report an adolescent with steroid-dependent idiopathic recurrent pericarditis that was successfully treated with anakinra, highlighting that this therapeutic option seems to be an effective, rapidly acting, steroid-sparing, and relatively safe agent for the treatment of this entity in children.

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Corresponding author

Author for correspondence: M. Rodriguez-Gonzalez, Department of Pediatric Cardiology, Puerta del Mar University Hospital, Ana de Viya Avenue 34, 11009 Cadiz, Spain. Tel: 34 956002700; Fax: 34 956002085; E-mail: moirogo@gmail.com

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Cite this article: Rodriguez-Gonzalez M, Ruiz-Gonzalez E, Castellano-Martinez A. (2018) Anakinra as rescue therapy for steroid-dependent idiopathic recurrent pericarditis in children: case report and literature review. Cardiology in the Young page 241 of 243. doi: 10.1017/S1047951118002020

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References

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Keywords

Anakinra as rescue therapy for steroid-dependent idiopathic recurrent pericarditis in children: case report and literature review

  • Moises Rodriguez-Gonzalez (a1), Estefania Ruiz-Gonzalez (a2) and Ana Castellano-Martinez (a3)

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