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Alterations in antioxidant and oxidant status of children after on-pump surgery for cyanotic and acyanotic congenital heart diseases

  • Firat H. Altin (a1), Hayriye A. Yildirim (a2), Ibrahim C. Tanidir (a3), Okan Yildiz (a1), Meliha Z. Kahraman (a4), Erkut Ozturk (a3), Sinem B. Celebi (a4), Mugisha Kyaruzi (a1) and İhsan Bakir (a1)...



Oxidative stress refers to an imbalance between reactive oxidative species and antioxidants. In this case-controlled, prospective, observational study, we investigated the total oxidant status, total antioxidant status, oxidative stress index, and albumin and C-reactive protein levels of children with cyanotic and acyanotic congenital heart diseases who had undergone on-pump cardiac surgery.


The study groups consisted of 60 patients with congenital heart disease, who were operated under cardiopulmonary bypass, and a control group of 30 healthy individuals. The patients were classified into two groups. Among them, one was a patient group that consisted of 30 patients with acyanotic congenital heart disease and the other group consisted of 30 patients with cyanotic congenital heart disease. In the patient groups, blood samples were collected before surgery and at one and 24 hours following surgery. In control groups, blood samples were collected once during hospital admission.


No statistically significant differences were found between the groups in terms of baseline total oxidant status, total antioxidant status, and oxidative stress index values. Regarding the postoperative first-hour and 24-hour total oxidant status and total antioxidant status levels as well as oxidative stress index values, there were no significant differences between the groups, except for an increase in total antioxidant status levels (p=0.002) 24 hours after surgery in cyanotic patients.


There was no difference between oxidative stress status of cyanotic and acyanotic congenital heart disease patients and healthy individuals. Oxidative stress status of cyanotic and acyanotic patients does not change after cardiac surgery under cardiopulmonary bypass.


Corresponding author

Correspondence to: F. H. Altin, MD, Istanbul Mehmet Akif Ersoy Thoracic And Cardiovascular Surgery Training and Research Hospital, Istasyon Mah.Turgut Ozal Bulvarı No:11 Kucukcekmece, Istanbul 34303, Turkey. Tel: +9 0212 692 20 00; Fax: +9 0212 471 94 94; E-mail:


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