Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-18T03:03:38.078Z Has data issue: false hasContentIssue false
  • English
  • Français

Neutrophil adhesion and the inflammatory response induced by cardiopulmonary bypass

Published online by Cambridge University Press:  19 August 2008

Adam Finn  and
William J. Dreyer
Adam Finn
Affiliation:
Department of Paediatrics, Children' Hospital, the University of Sheffield, Sheffield, and the Lillie FrankHouston
William J. Dreyer*
Affiliation:
Abercrombie Section of Cardiology, the Speros P. Martel Section of Leukocyte Biology and Inflammation Research, Department of Pediatrics and the Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston
*
Dr. William J. Dreyer, Pediatric Cardiology, Texas Children's Hospital, 6621 Fannin, Houston, Texas 77005, USA, Tel. (713) 770-5639; Fax. (713) 770-5630.
Get access Rights & Permissions [Opens in a new window]

Extract

The activation of inflammatory systems as a consequence of cardiopulmonary bypass represents one possible means by which inj ury to tissues and associated dysfunction of organs may occur in the postoperative cardiac patient, both pediatric and adult. Kirklin and colleagues demonstrated in the early 1980's that complement activation occurs as a consequence of blood exposure to the extracorporeal circuit. Subsequent studies demonstrated this to be true in systems using both bubble and membrane oxygenators. The anaphylatoxin C5a and its metabolite C5a des arg are produced during activation of the complement cascade. They are potent stimulants which may induce activation of neutrophils. This activation may be manifested as changes in shape, decreased cellular deformability, and changes in adhesive and secretory function. Activation of neutrophils by these fragments of complement could contribute to neutrophilmediated damage to tissues by promoting retention of neutrophils in vascular beds and secretion of cytotoxic substances. Recent studies demonstrating the release of neutrophil granular enzymes into the plasma following cardiopulmonary bypass are evidence that activation of neutrophils is taking place in this setting.

Keywords

Neutrophilscomplementinflammationcardiopulmonary bypass
Type
World Forum for Pediatric Cardiology Symposium on Cardiopulmonary Bypass (Part 1)
Information
Cardiology in the Young , Volume 3 , Issue 3 , July 1993 , pp. 244 - 250
Copyright
Copyright © Cambridge University Press 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Chenoweth, DE, Cooper, SW, Hugh, TE, Stewart, RW, Blackstone, EH, Kirklin, JW. Complement activation during cardiopulmonary bypass: Evidence for generation of C3a and C5a anaphylatoxins. N Engl J Med 1981; 304: 497–503.CrossRefGoogle ScholarPubMed
2.Kirklin, JK, Westaby, S, Blackstone, EH, Kirklin, JW, Chenoweth, DE, Pacifico, AD. Complement and the damaging effects of cardiopulmonary bypass. J Thorac Cardiovasc Surg 1983; 86: 845–857.CrossRefGoogle ScholarPubMed
3.van Oeveren, W, Kazatchkine, MD, Descamps-Latscha, B, Maillet, F, Fischer, E, Carpentier, A, Wildevuur, CRH. Deleterious effects of cardiopulmonary bypass: A prospective study of bubble versus membrane oxygenation. J Thorac Cardiovasc Surg 1985; 89: 888–899.CrossRefGoogle ScholarPubMed
4.Tamiya, T, Yamasaki, M, Maeo, Y, Yamashiro, T, Ogoshi, S, Fujimoto, S. Complement activation in cardiopulmonary by pass, with special reference to anaphylatoxin production in membrane and bubble oxygenators. Ann Thorac Surg 1988; 46: 47–57.CrossRefGoogle Scholar
5.Faymonville, ME, Pincemail, J, Duchateau, J, Paulus, JM, Adam, A, Deby-Dupont, G, Deby, C, Albert, A, Larbuisson, R, Limet, R, Lamy, M. Myeloperoxidase and elastase as markers of leukocyte activation during cardiopulmonary bypass in humans. J Thorac Cardiovas Surg 1991; 102: 309–317.CrossRefGoogle ScholarPubMed
6.Wachtfogel, YT, Kucich, U, Greenplate, J, Gluszko, P, Abrams, W, Weinbautn, G, Wenger, RK, Rucinski, B, Niewiarowski, S, Edmunds, LH, Colman, RW. Human neutrophil degranulation during extracorporeal circulation. Blood 1987; 69: 324–330.CrossRefGoogle ScholarPubMed
7.Hind, CRK, Griffin, JF, Pack, S, Latchman, YE, Drake, HF, Jones, HM, Brosroff, J, Dormandy, TL, Treasure, T. Effect of cardiopulmonary bypass on circulating concentrations of leucocyte elastase and free radical activity. Cardiovas Rca 1988; 22: 37–41.CrossRefGoogle ScholarPubMed
2.Cohnheim, J. Lectures on general pathology (translated from the second German edition). The New Sydenham Society, London, 1889.Google Scholar
9.Butcher, EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991; 67: 1033–1036.CrossRefGoogle ScholarPubMed
10.Pober, JS, Cotran, RS. The role of endothelial cells in inflammation. Transplantation 1990; 50: 537–544.CrossRefGoogle ScholarPubMed
11.Spertini, O, Luscinskas, FW, Kansas, GS, Munro, JM, Griffin, JD, Gimbrone, MA JrTedder, TF. Leukocyre adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol 1991; 147: 2565–2573.CrossRefGoogle ScholarPubMed
12.Abbassi, O, Kishimoto, TK, Mclntire, LV, Smith, CW. Neutro phil adhesion to endothelial cells. Blood Cells 1993. [In press]Google Scholar
13.Jones, DA, Abbassi, O, Mclntire, LV, McEver, RP, Smith, CW. Neutrophil-endothelial adherence under conditions of flow: P-selectin supports leukocyte rolling. Circulation 1992; 86(Suppl I): I 161. [Abstract]Google Scholar
14.Kishimoto, TK, Jutila, MA, Berg, EL, Butcher, EC. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 1989; 245: 1238–1241.CrossRefGoogle ScholarPubMed
15.Dustin, ML, Springer, TA. Lymphocyte function associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. J Cell Biol 1988; 107: 321–331.CrossRefGoogle ScholarPubMed
16.Richter, J, Ng Sikorski, J, Olsson, I, Anderson, T. Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosohic free Ca2+. Proc Nail Acad Sci USA 1990; 87: 9472–9476.CrossRefGoogle ScholarPubMed
17.Shappell, SB, Toman, C, Anderson, DC, Taylor, AA, Entman, ML, Smith, CW. Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. J Immunol 1990; 144: 2702–2711.CrossRefGoogle ScholarPubMed
18.Finn, A, Rebuck, N, Moat, N. Neutrophil activation during cardiopulmonary bypass. J Thorac Cardiovasc Surg 1992; 104: 1746–1748.CrossRefGoogle ScholarPubMed
19.Finn, A, Moat, N, Rebuck, N, Strobel, S, Elliott, M. Systemic inflammation during paediatric cardiopulmonary bypass: changes in neutrophil adhesive properties. Perfusion 1993; 8: 37–46.CrossRefGoogle Scholar
20.Dreyer, WJ, Michael, LH, Nguyen, T, Lame, GA, Liedtke, G, Jackson, P, Entman, ML, Smith, CW. Neutrophil-mediated pulmonary injury in a canine model of cardiopulmonary bypass: Evidence for a CD 18-dependent mechanism. Circulation 1992; 86(Suppl I): I 629. [Abstract]Google Scholar
21.Gillinov, AM, Redmond, JM, Zehr, KJ, Wilson, IC, Curtis, WE, Bator, JM, Burch, RM, Herskowirz, A, Reitz, BA, Baumgartner, WA, Cameron, DR. Inhibition of neutrophil adhesion reduces pulmonary injury due to cardiopulmonary bypass. Circulation 1992; 86(Suppl I): I 354. [Abstract]Google Scholar
22.Braude, S, Nolop, KB, Fleming, JS, Krausz, T, Taylor, KM, Royston, D. Increased pulmonary transvascular protein flux after canine cardiopulmonary bypass. Association with lung neutrophil sequestration and tissue peroxidation. Am Rev Respir Dis 1986; 134: 867–872.CrossRefGoogle ScholarPubMed
23.Howard, RJ, Cram, C, Franzini, DA, Hood, CI, Hugh, TE. Effects of cardiopulmonary bypass on pulmonary leukosrasis and comple ment activation. Arch Surg 1988; 123: 1496–1501.CrossRefGoogle Scholar
24.Donnelly, SC, Haslett, C. Cellular mechanisms of acute lung injury: Implications for future treatment in the adult respiratory distress syndrome. Thorax 1992; 47: 260–263.CrossRefGoogle ScholarPubMed
25.Lawrence, MBSmith, CW, Eskin, SG, Mclntire, LV. Effect of venous shear stress on CD 18-mediated neutrophil adhesion to cultured endothelium. Blood 1990; 75: 227–237.CrossRefGoogle Scholar
26.Wilson, IC, Gillinov, AM, Curtis, WE, DiNatale, J, Burch, RM, Cameron, DE, Gardner, TJ. Inhibition of neutrophil adhesion improves postischaemic ventricular performance of the neo natal heart. Circulation 1992; 86(Suppl I): I 631. [Abstract]Google Scholar
27.Gillinov, AM, DeValeria, PA, Winkelstein, JA, Wilson, I, Curtis, WE, Shaw, D, Yeh, CG, Rudolph, AR, Baumgartner, WA, Herskowitz, A, Cameron, DE. Complement inhibition with soluble complement receptor type 1 in cardiopulmonary bypass. Ann Thorac Surg 1993. [press]CrossRefGoogle ScholarPubMed
28.Rinder, CS, Bonan, JL, Rinder, HM, Mathew, J, Hines, R, Smith, BR. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992; 79: 1201–1205.CrossRefGoogle ScholarPubMed
29.Finn, A, Naik, S, Klein, N, Levinsky, Rj, Strobel, S, Elliott, M. Interleukin 8 release and neutrophil degranulation after paediatric cardiopulmonary bypass. J Thorac Cardiovasc Surg 1993. [press]CrossRefGoogle Scholar
30.Smith, CW, Kishimoto, TK, Abbass, O. Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1) -dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro. J Clin Invest 1991; 87: 609–618.CrossRefGoogle ScholarPubMed
31.Detmers, PA, Lo, SK, Olsen, E, Walz, A, Baggiohini, M, Cohn, ZA. Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD 11 b/CD 18 on human neutrophils. J Exp Med 1990; 171: 1155–1162.CrossRefGoogle Scholar
32.Huber, AR, Kunkel, SL, Todd, RF III, Weiss, SJ. Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science 1991; 254: 99–102.CrossRefGoogle ScholarPubMed
33.Van Damme, J, Rampart, M, Conings, R. The neutrophil activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison ofNH2-terminally processed forms. Eur J Immunol 1990; 20: 2113–2118.CrossRefGoogle ScholarPubMed
34.Leonard, EJ, Yoshimura, T, Tanaka, S, Raffeld, M. Neutrophil recruitment by intradermally injected neutrophil attractant/activation protein-1. J Invest Dermatol 1991; 96: 690–694.CrossRefGoogle ScholarPubMed
35.Rot, A. Some aspects of NAP-1 pathophysiology: lung damage caused by a blood-borne cytokine. Adv Exp Med Biol 1991; 305: 127–135.CrossRefGoogle ScholarPubMed