The 40th annual meeting of the Canadian Association of Neuropathologists was held from October 18 - 21st, 2000 at The Banff Centre in Banff, Alberta. Local arrangements were made by Drs. Bernadette Curry and Barry Rewcastle. The scientific session consisted of 15 platform presentations and 13 cases for diagnosis. The Royal College of Physicians and Surgeons of Canada speaker was Dr. James Rutka, Professor and Chair, Department of Neurosurgery, University of Toronto and The Hospital for Sick Children. His talk was entitled “New Insights into the Molecular Genetics and Pathology of Human Brain Tumors”. The Jerzy Olszewski lecturer was Dr. Voon Wee Yong, Associate Professor, AHFMR Senior Scholar and MRC Scientist, Departments of Oncology and Clinical Neurosciences, University of Calgary. His talk was entitled “Complexities of Neuro-inflammation: Pathology and Regeneration”. The invited lecturer was Dr. Catherine Bergeron, Neuropathologist, Centre for Research in Neurodegenerative Diseases, University of Toronto and Toronto Western Hospital. Her talk was entitled “The Many Faces of Human Prion Diseases”.