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Ventricular Size, Cognitive Function and Depression in Patients with Multiple Sclerosis

Published online by Cambridge University Press:  18 September 2015

Campbell M. Clark ,
Gerald James ,
David Li ,
Joel Oger ,
Donald Paty  and
Harry Klonoff
Campbell M. Clark*
Affiliation:
Department of Psychiatry
David Li
Affiliation:
Department of Radiology
Joel Oger
Affiliation:
Division of Neurology, Department of Medicine
Donald Paty
Affiliation:
Division of Neurology, Department of Medicine
Harry Klonoff
Affiliation:
Department of Psychiatry
*
Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A1
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Abstract:

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The purpose of this study was to explore further the hypothesis that changes in cognitive function may occur in the mild stages of multiple sclerosis (MS) by determining whether ventricular enlargement was related to cognitive function. Ten measures of ventricular size were made in a sample of 123 MS patients with mild disability and 60 well-matched healthy controls. In addition, sixteen tests of cognitive function and the Beck Depression Inventory were administered. For the MS group, there were significant correlations between the ventricular measures and cognitive performance but not for the normal controls. Scores on the Beck Depression Inventory were not correlated with either cognitive performance or ventricular enlargement. These findings suggest that for the MS group cognitive impairment was related to the disease process but not to the level of depression.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 3 , August 1992 , pp. 352 - 356
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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