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TGF-beta 1 Codon 10 Polymorphism is Associated with Cerebral SVD

  • Hong-miao Tao (a1), Guo-zhong Chen (a1), Xiao-dong Lu (a2), Xiao-gang Hu (a3), Gan-ping Chen (a4) and Bei Shao (a5)...

Abstract

Background:

To clarify the role of inflammation in the pathogenesis of cerebral small vessel disease (SVD), we investigated whether the gene encoding transforming growth factor-beta 1(TGF-beta 1) is a risk factor for cerebral SVD as a whole, and for two different SVD subtypes.

Methods:

TGF-beta 1 codon10 (T+29C) genotype was determined in 441 Chinese patients (313 male and 128 female) with cerebral SVD and 450 control subjects (326 male and 124 female). Cerebral SVD patients were retrospectively classified into two groups based on neuroimaging findings: lacunar infarction group with 112 patients and ischaemic leukoaraiosis group with 329 patients.

Results:

Subjects carrying TT homozygote were susceptible to cerebral SVD [adjusted odds ratio (OR) =1.44, 95% confidence interval (CI), 1.05-1.98; P=0.026]. Further analysis of SVD subtypes revealed a moderate association with the ischaemic leukoaraiosis group [OR= 1.60, 95% CI, 1.14-2.25; P=0.007].

Conclusions:

Codon 10 of TGF-beta 1 might be a risk factor for SVD, specifically in ischaemic leukoaraiosis phenotype.

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Copyright

Corresponding author

School of Medicine, Jinhua College of Profession & Technology, Jinhua, 321007, Zhejiang Province, The People's Republic of China.

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