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Temporal Lobe Epilepsy as a Unique Manifestation of Multiple Sclerosis

Published online by Cambridge University Press:  02 December 2014

Antonio Gambardella ,
Paola Valentino ,
Angelo Labate ,
Grazia Sibilia ,
Francesca Ruscica ,
Eleonora Colosimo ,
Rita Nisticò ,
Demetrio Messina ,
Mario Zappia  and
Aldo Quattrone
Antonio Gambardella
Affiliation:
Institute of Neurology School of Medicine, Catanzaro, Italy Institute of Neurological Sciences National Research Council, Cosenza, Italy
Paola Valentino
Affiliation:
Institute of Neurology School of Medicine, Catanzaro, Italy Institute of Neurological Sciences National Research Council, Cosenza, Italy
Angelo Labate
Affiliation:
Institute of Neurological Sciences National Research Council, Cosenza, Italy
Grazia Sibilia
Affiliation:
Institute of Neurology School of Medicine, Catanzaro, Italy
Francesca Ruscica
Affiliation:
Institute of Neurology School of Medicine, Catanzaro, Italy
Eleonora Colosimo
Affiliation:
Institute of Neurology School of Medicine, Catanzaro, Italy
Rita Nisticò
Affiliation:
Institute of Neurology School of Medicine, Catanzaro, Italy
Demetrio Messina
Affiliation:
Institute of Neurological Sciences National Research Council, Cosenza, Italy
Mario Zappia
Affiliation:
Institute of Neurology School of Medicine, Catanzaro, Italy Institute of Neurological Sciences National Research Council, Cosenza, Italy
Aldo Quattrone
Affiliation:
Institute of Neurology School of Medicine, Catanzaro, Italy Institute of Neurological Sciences National Research Council, Cosenza, Italy
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Abstract

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Objective:

To report on five patients with temporal lobe epilepsy (TLE) as the unique manifestation of multiple sclerosis (MS).

Methods:

Among 350 consecutive MS patients, we identified 16/350 (4.6%) who also had epileptic seizures. Here, we review their electrophysiological and clinical features.

Results:

Five of these 16 patients (four female, one male; mean age 34.2 years; range 31 to 38) with MS and epileptic seizures had an extremely homogeneous clinical picture characterized by TLE as the unique manifestation of MS, even at long follow-up (mean: five years; range 4 to 10). In all patients, seizures started in the second or third decade. Brain MRI revealed at least one juxta-cortical lesion within the temporal region. Antiepileptic medication was always effective.

Conclusions:

The present study provides the first evidence of a peculiar form of MS characterized by TLE as the unique manifestation of the disease with no disability or MS relapses at long-term follow-up.

Résumé:

RÉSUMÉ:Objectif:

Rapporter les cas de cinq patients présentant une épilepsie temporale (ÉT) comme seule manifestation de la sclérose en plaques (SEP)

Méthodes:

Nous avons identifié 16 patients parmi 350 patients consécutifs (4,6%) atteints de SEP qui présentaient également des crises d’épilepsie. Nous avons revu leurs caractéristiques électro-clinique.

Résultats:

Cinq de ces 16 patients, quatre femmes et un homme, dont l’âge moyen était de 34,2 ans (écart de 31 à 38 ans), atteints de SEP et présentant des crises d’épilepsie avaient un tableau clinique extrêmement homogène caractérisé par une ÉT comme manifestation isolée de la SEP, même après un suivi à long terme (moyenne de cinq ans, écart de 4 à 10 ans). Chez tous les patients, les crises avaient commencé dans la deuxième ou troisième décennie. L’IRM du cerveau montrait au moins une lésion juxta-corticale dans la région temporale. La médication antiépileptique était efficace dans tous les cas.

Conclusions:

Cette étude est la première à rapporter une forme inusitée de SEP caractérisée par une ÉT comme manifestation isolée de la maladie, sans invalidité ou récidive de la SEP au suivi à long terme.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 30 , Issue 3 , August 2003 , pp. 228 - 232
Copyright
Copyright © The Canadian Journal of Neurological 2003

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