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The Significance of White Matter Lucencies on CT Scan in Relation to Cognitive Impairment

Published online by Cambridge University Press:  18 September 2015

A. Steingart ,
K. Lau ,
A. Fox ,
F. Diaz ,
M. Fisman ,
V. Hachinski ,
H. Merskey  and
University of Western Ontario Dementia Study Group
A. Steingart
Affiliation:
Department of Education & Research, London Psychiatric Hospital, London, Ontario
K. Lau
Affiliation:
Department of Clinical Neurological Sciences, University Hospital, London, Ontario
A. Fox
Affiliation:
Department of Clinical Neurological Sciences, University Hospital, London, Ontario
F. Diaz
Affiliation:
Department of Clinical Neurological Sciences, University Hospital, London, Ontario
M. Fisman
Affiliation:
Department of Education & Research, London Psychiatric Hospital, London, Ontario
V. Hachinski
Affiliation:
Department of Clinical Neurological Sciences, University Hospital, London, Ontario
H. Merskey*
Affiliation:
Department of Education & Research, London Psychiatric Hospital, London, Ontario
*
London Psychiatric Hospital, Department of Education & Research, 850 Highbury Avenue. P.O. Box 2532, Terminal A, London, Ontario, Canada N6A 4H1
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Abstract:

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As part of a prospective clinicopathological study a cohort of “normal” elderly volunteers (n = 110) has been investigated with CT scans, psychometric testing (Extended Scale for Dementia) and neurological examination. CT scans were evaluated by a neuroradiologist for the presence or absence of white matter lucencies (WML). WML were defined as patchy or diffuse areas of decreased attenuation involving only white matter and with no change in adjacent ventricles or sulci.

The 12 subjects with WML had lower scores on the ESD than the 98 subjects without WML (mean ESD with WML 229.5± 14; without WML 236.7±8.6, t-test p<.01) and the difference remains significant even after adjusting for the possible confounding effects of age (ANCOVA, P<.043).

Type
Clinical and Therapeutic Issues
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 383 - 384
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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