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PS1 - 176 Where Have All the Fat Cells Gone? A Comparative Analysis of Adiposity Patterns in Childhood Brain Tumor Survivors and Non-Cancer Controls

Published online by Cambridge University Press:  18 October 2016

K.W. Wang ,
E. Kearsley ,
N. Falzone ,
A. Fleming ,
S. Burrow ,
R.J. de Souza ,
L. Thabane  and
M.C. Samaan
K.W. Wang*
Affiliation:
Department of Pediatrics, McMaster University, Hamilton, ON Division of Pediatric Endocrinology, McMaster Children’s Hospital, Hamilton, ON
E. Kearsley
Affiliation:
Department of Pediatrics, McMaster University, Hamilton, ON Division of Pediatric Endocrinology, McMaster Children’s Hospital, Hamilton, ON
N. Falzone
Affiliation:
Department of Pediatrics, McMaster University, Hamilton, ON Division of Pediatric Endocrinology, McMaster Children’s Hospital, Hamilton, ON
A. Fleming
Affiliation:
Department of Pediatrics, McMaster University, Hamilton, ON Division of Pediatric Hematology/Oncology, McMaster Children’s Hospital, Hamilton, ON
S. Burrow
Affiliation:
Division of Orthopedic Surgery, Department of Surgery, McMaster University Medical Centre, Hamilton, ON
R.J. de Souza
Affiliation:
Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON
L. Thabane
Affiliation:
Department of Pediatrics, McMaster University, Hamilton, ON Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON Department of Anesthesia, McMaster University, Hamilton, ON Centre for Evaluation of Medicines, St. Joseph’s Health Care, Hamilton, ON Biostatistics Unit, St Joseph’s Healthcare, Hamilton, ON
M.C. Samaan
Affiliation:
Department of Pediatrics, McMaster University, Hamilton, ON Division of Pediatric Endocrinology, McMaster Children’s Hospital, Hamilton, ON Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON
*
wangkw2@mcmaster.ca
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Abstract

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Brain tumors are the most common solid tumors in children in Canada. While technological advances have increased their survival rates, survivors of childhood brain tumors (SCBT) often develop obesity, which can reduce lifespan and quality of life. While adiposity is a known factor for cardiometabolic disorders in the general population, adiposity patterns in SCBT have not been determined. This study aims to investigate how adiposity patterns differ between SCBT and non-cancer controls, and how lifestyle and treatment factors may contribute to these patterns. Methods: Fifty-nine SCBT and 108 non-cancer controls were recruited from the clinics at McMaster Children’s Hospital. Sociodemographic and lifestyle details were collected using standardized tools to assess diet, physical activity, and sleep. Brain tumor type, location and treatment details were obtained from medical records. Total and visceral adiposity were determined by total fat mass (FM) as well as waist-to-hip (WHR) and waist-to-height ratio (WHTR). Results: SCBT have higher total and visceral adiposity, while BMI is similar to controls. Female SCBT who received radiotherapy and/or chemotherapy have higher adiposity. A dietary pattern of white bread and fried foods with low dark bread was positively associated with adiposity. Lower physical activity levels, but not sleep durations, were associated with higher adiposity. Conclusion: SCBT have higher visceral and total adiposity than non-cancer controls. Sex, chemoradiotherapy, high fat diet, and physical inactivity, can contribute to these adiposity patterns. These results provide multiple points of entry to design interventions that reduce adiposity, and may improve long-term outcomes in SCBT.

Type
Poster Viewing Sessions
Information
Canadian Journal of Neurological Sciences , Volume 43 , Supplement S4: ABSTRACTS: 17th Biennial Canadian Neuro-Oncology Meeting , October 2016 , pp. S11
Copyright
Copyright © The Canadian Journal of Neurological Sciences Inc. 2016