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Limbic Encephalitis Associated With GAD65 Antibodies: Brief Review of the Relevant literature

  • Maude-Marie Gagnon (a1) and Martin Savard (a1)

Abstract

Recently, many cases of autoimmune limbic encephalitis with positive GAD65 (glutamic acid decarboxylase) antibodies have been described in the scientific literature. However, it remains an understudied topic of great relevance to practicing neurologists. Thus, we report here a review of published cases, in English, of autoimmune limbic encephalitis with this type of antibodies, focusing on presenting symptoms and signs, associated conditions, and findings upon investigation. We also report treatment responses. We aim to offer a better description of the clinical spectrum of autoimmune limbic encephalitis associated with GAD65 antibodies as well as to expose its paraclinical features and outcome.

Au cours des dernières années, plusieurs cas d’encéphalite limbique avec anticorps GAD65 (glutamic acid decarboxylase) ont été décrits dans la littérature. Néanmoins, il s’agit d’un sujet relativement peu connu, mais qui s’avère pertinent à bien connaître pour les neurologues praticiens. Ainsi, nous proposons une revue des différents cas publiés, en anglais, d’encéphalite limbique auto-immune associés à cet anticorps. Celle-ci se concentre sur la présentation clinique, les conditions associées de même que les trouvailles à l’investigation. De surcroît, nous proposons une revue des traitements utilisés et de leurs réponses. Cet article a pour objectif premier d’obtenir une meilleure description du spectre clinique de l’encéphalite auto-immune avec anticorps GAD65 et, dans un second temps, d’exposer ses caractéristiques paracliniques ainsi que son évolution.

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Copyright

Corresponding author

Correspondence to: Maude-Marie Gagnon, Enfant-Jésus Hospital – Neurology, 1401, 18th Street Quebec, Quebec G1J 1Z4, Canada. Email: maude-marie.gagnon.1@ulaval.ca

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