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Intradural Metastasis from Cutaneous Squamous Cell Carcinoma Causing Cauda Equina Syndrome

  • François Mathieu (a1), Fan Jiang (a1) (a2), Jamie R.F. Wilson (a1), Phedias Diamandis (a3), David Choi (a4), Peter Vajkoczy (a5) and Michael G. Fehlings (a1)...


Corresponding author

Correspondence to: Michael G. Fehlings MD, PhD, FRCSC, FACS, Division of Neurosurgery and Spinal Program, Department of Surgery, University of Toronto, Krembil Neuroscience Center, Toronto Western Hospital, 399 Bathurst St., Suite 4W-449, Toronto, Ontario, M5T 2S8 Canada. Email:


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1. Rades, D, Schiff, D. Epidural and intramedullary spinal metastasis: clinical features and role of fractionated radiotherapy. Handb Clin Neurol. 2018;149:227–38.
2. Mut, M, Schiff, D, Shaffrey, ME. Metastasis to nervous system: spinal epidural and intramedullary metastases. J Neurooncol. 2005;75(1):4356.
3. Johnson, TM, Rowe, DE, Nelson, BR, Swanson, NA. Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol. 1992;26(3 Pt 2):467–84.
4. Weinberg, AS, Ogle, CA, Shim, EK. Metastatic cutaneous squamous cell carcinoma: an update. Dermatol Surg. 2007;33(8):885–99.
5. Brantsch, KD, Meisner, C, Schonfisch, B, et al. Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol. 2008;9(8):713–20.
6. Jennings, L, Schmults, CD. Management of high-risk cutaneous squamous cell carcinoma. J Clin Aesthet Dermatol. 2010;3(4):3948.
7. Zhu, JJ, Padillo, O, Duff, J, Hsi, BL, Fletcher, JA, Querfurth, H. Cavernous sinus and leptomeningeal metastases arising from a squamous cell carcinoma of the face: case report. Neurosurgery. 2004;54(2):492–8; discussion 8–9.
8. Begemann, M, Rosenblum, MK, Loh, J, Kraus, D, Raizer, JJ. Leptomeningeal metastases from recurrent squamous cell cancer of the skin. J Neurooncol. 2003;63(3):295–8.
9. Roh, J, Muelleman, T, Tawfik, O, Thomas, SM. Perineural growth in head and neck squamous cell carcinoma: a review. Oral Oncol. 2015;51(1):1623.
10. Leibovitch, I, Huilgol, SC, Selva, D, Hill, D, Richards, S, Paver, R. Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia II. Perineural invasion. J Am Acad Dermatol. 2005;53(2):261–6.
11. Wostrack, M, Pape, H, Kreutzer, J, Ringel, F, Meyer, B, Stoffel, M. Surgical treatment of spinal intradural carcinoma metastases. Acta Neurochir (Wien). 2012;154(2):349–57.
12. Preciado, DA, Sebring, LA, Adams, GL. Treatment of patients with spinal metastases from head and neck neoplasms. Arch Otolaryngol Head Neck Surg. 2002;128(5):539–43.
13. Cansever, T, Kabatas, S, Civelek, E, Yilmaz, C, Caner, H. Spinal metastasis of occult lung carcinoma causing cauda equine syndrome with lumbar spinal stenosis. Turk Neurosurg. 2011;21(3):408–12.
14. Cho, DY, Wang, YC, Chen, JT. Intradural metastasis to the cauda equina from carcinoma of the anus. Spine (Phila Pa 1976). 1995;20(21):2341–4.
15. Thompson, SR, Veness, MJ, Morgan, GJ, Shannon, J, Kench, JG. Leptomeningeal carcinomatosis from squamous cell carcinoma of the supraglottic larynx. Australas Radiol. 2003;47(3):325–30.
16. Lindauer, S, Martinez, M. Intramedullary spinal cord and leptomeningeal metastases presenting as cauda equina syndrome in a patient with melanoma. Journal of Community and Supportive Oncology. 2017;15(4):e2247.
17. Kokkoris, CP. Leptomeningeal carcinomatosis. How does cancer reach the pia-arachnoid? Cancer. 1983;51(1):154–60.
18. Fehlings, MG, Nater, A, Tetreault, L, et al. Survival and clinical outcomes in surgically treated patients with metastatic epidural spinal cord compression: results of the prospective multicenter AOSpine study. J Clin Oncol. 2016;34(3):268–76.



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