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Friedreich's Ataxia and Oral Glucose Tolerance: II. The effect of ingested glucose on serum growth hormone in homozygotes, obligate heterozygotes and potential carriers of the Friedreich's Ataxia gene

Published online by Cambridge University Press:  18 September 2015

G. Tolis ,
A. Mehta ,
C. Harvey ,
E. Andermann ,
F. Andermann  and
A. Barbeau
G. Tolis
Affiliation:
Royal Victoria Hospital, Montreal and Montreal Neurological Institute; Clinical Research Institute of Montreal
A. Mehta
Affiliation:
Royal Victoria Hospital, Montreal and Montreal Neurological Institute; Clinical Research Institute of Montreal
C. Harvey
Affiliation:
Royal Victoria Hospital, Montreal and Montreal Neurological Institute; Clinical Research Institute of Montreal
E. Andermann
Affiliation:
Royal Victoria Hospital, Montreal and Montreal Neurological Institute; Clinical Research Institute of Montreal
F. Andermann
Affiliation:
Royal Victoria Hospital, Montreal and Montreal Neurological Institute; Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Royal Victoria Hospital, Montreal and Montreal Neurological Institute; Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7
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Summary:

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Homozygotes, obligatory heterozygotes and potential carriers of the Friedreich's Ataxia gene were tested with an oral glucose tolerance in order to assess a. the prevalence of abnormalities in glucose handling, b. the secretory pattern of two “diabetogenic” hormones, growth hormones and prolactin and c. to evaluate the possibility for detection of an abnormal trend in these hormones to be used as a genetic marker. Despite the high prevalence of glucose abnormalities horizontally and vertically in these families, the basal output and responses of these metabolic hormones to a glucose challenge were appropriate and thus not characteristic of any of the above groups.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 401 - 403
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

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