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The Fluctuating Parkinsonian Patient - Clinical and Pathophysiological Aspects

  • Pierre J. Blanchet (a1)

Abstract

Although levodopa-related motor response complications remain challenging from a pathophysiological and therapeutic standpoint, major advances have been made in the last decade, supporting the development of several promising drugs. Eventually, these drugs may help us to prevent, alleviate, or even “deprime” these frequent and disabling complications. Knowledge of the basic mechanisms and hypotheses underlying this fascinating conversion in the parkinsonian brain allows neurologists to understand the rationale behind emerging treatment strategies.

RÉSUMÉ

Les complications motrices associées à la dopathérapie chez le Parkinsonien constituent toujours un défi au plan théorique et thérapeutique mais des progrès majeurs ont été réalisés durant la dernière décennie, favorisant le développement de plusieurs médications prometteuses. Il n’est peut-être pas loin le jour où ces nouveaux agents pourront prévenir, soulager ou même renverser pour de bon (“déprogrammer”) ces complications fréquentes et handicapantes. Une connaissance des mécanismes fondamentaux à l’origine de cette fascinante conversion dans le cerveau parkinsonien et des hypothèses explorées permet aux neurologues de mieux comprendre la logique entourant les stratégies correctrices en émergence.

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References

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