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A Cluster-Focus of Multiple Sclerosis at Henribourg, Saskatchewan

Published online by Cambridge University Press:  18 September 2015

Walter J. Hader*
Affiliation:
Department of Rehabilitation Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon
Donald G. Irvine
Affiliation:
Toxicology Research Centre, University of Saskatchewan, Saskatoon
H. Bruno Schiefer
Affiliation:
Toxicology Research Centre, University of Saskatchewan, Saskatoon
*
Department of Rehabilitation Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada S7N 0X0
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Abstract:

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This study presents the clinical characteristics of 8 victims of multiple sclerosis from the hamlet of Henribourg, Saskatchewan with a population of less than 75 people. A diligent victim of the disease had observed that six female classmates from the early 1940's had later developed multiple sclerosis. Two male military personnel who had also resided briefly in close proximity, during the same common exposure time, also later developed multiple sclerosis. The mean onset time of developing the disease after leaving the area was 20 years. This cluster-focus suggests a common exposure to an environmental factor or a common infective agent in the etiology of multiple sclerosis.

Type
Original Articles
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

REFERENCES

1.Millar, JH. In: Multiple sclerosis. A disease acquired in childhood. Charles & Thomas Publisher 1971; 2: 1418.Google Scholar
2.Schapira, K, Poskanzer, OC, Miller, H. Familial and conjugal multiple sclerosis. Brain 1963; 86: 315332.CrossRefGoogle ScholarPubMed
3.Kurtzke, JF. On the time of onset in multiple sclerosis. Acta Neurol Scand 1965; 41: 140158.CrossRefGoogle ScholarPubMed
4.Bammer, H, Schaltenbrand, G. Disseminated sclerosis: a survey in forty-six communities of western lower franconia. Acta Psychiat Neurol Scand 1960; 35(147): 5163.Google Scholar
5.Alter, M, Leibowitz, U, Speer, J. Risk of multiple sclerosis related to age at immigration to Israel. Arch Neurol 1966; 15: 234237.Google ScholarPubMed
6.Dean, G, Kurtzke, JF. On the risk of multiple sclerosis according to age at immigration to South Africa. Brit Med J 1971; 3: 725729.CrossRefGoogle ScholarPubMed
7.Acheson, Ed. The epidemiology of multiple sclerosis. In: Matthews, WB, ed. McAlphine’s multiple sclerosis. Edinburgh: Churchill Livingstone 1985; 20.Google Scholar
8.Ebers, GC, Bulman, DE, Sadovnick, AD, et al. A population-based study of multiple sclerosis in twins. N Engl J Med 1986; 315: 16381642.CrossRefGoogle ScholarPubMed
9.Deacon, WE, Alexander, L, Siedler, HD, Kurland, LT. Multiple sclerosis in a small New England community. New Eng J Med 1959; 261: 10591061.CrossRefGoogle Scholar
10.Eastman, R, Sheridan, J, Poskanzer, DC. Multiple sclerosis clustering in a small Massachusetts community with possible common exposure 23 years before onset. New Engl J Med 1973; 289: 793794.CrossRefGoogle Scholar
11.Koch, MJ, Reed, D, Stern, R, et al. Multiple sclerosis: a cluster in a small northwestern United States community. JAMA 1974; 228: 15551557.CrossRefGoogle Scholar
12.Murray, TJ. An unusual occurrence of multiple sclerosis in a small rural community. Can J Neurol Sci 1976; 3: 163166.Google Scholar
13.Martin, D. A diligent victim helps unearth clues to multiple sclerosis. The New York Times 1985; March 19: 23 (Col. 1-6).Google Scholar
14.Buckland History Book Committee. Buckland’s heritage. Turner-Warwick Printers, North Battleford, Saskatchewan, Canada 1980.Google Scholar
15.Irvine, DG, Schiefer, HB, Hader, WJ. Geotoxicology of multiple sclerosis. The Henribourg Saskatchewan cluster focus 1: the water. Sci Tot Envir 1989; 84: 4549.CrossRefGoogle Scholar
16.Irvine, DG, Schiefer, HB, Hader, WJ. Geotoxicology of multiple sclerosis. The Henribourg Saskatchewan cluster focus 2: the soil. Sci Tot Envir 1988; 77: 175188.CrossRefGoogle Scholar
17.Hader, WJ, Elliot, M, Ebers, GC. Epidemiology of multiple sclerosis in London and Middlesex County, Ontario, Canada. Neurology 1988; 38: 617621.CrossRefGoogle ScholarPubMed
18.Hader, WJ. Prevalence of multiple sclerosis in Saskatoon. Can Med Assoc J 1982; 127: 295297.Google ScholarPubMed
19.Sweeney, VP, Sadovnick, AD, Brandejs, V. Prevalence of multiple sclerosis in British Columbia. Can J Neurol Sci 1986; 13: 4751.Google ScholarPubMed
20.Campbell, AMG, Herdan, G, Tatlow, WFT, et al. Lead in relation to disseminated sclerosis. Brain 1950; 73: 5271.CrossRefGoogle ScholarPubMed
21.Sutherland, JM. Observations on the prevalence of multiple sclerosis in northern Scotland. Brain 1956; 79: 635654.Google ScholarPubMed
22.Millar, JHD. Multiple sclerosis, two high risk areas in northern Ireland. J Irish Med Assoc 1966; 59: 138143.Google ScholarPubMed
23.Wikstrom, J, Palo, J. Studies on the clustering of multiple sclerosis in Finland. I. Comparison between the domiciles and places of birth in selected subpopulations. Acta Neurol Scand 1975; 51: 8598.CrossRefGoogle ScholarPubMed
24.Hargreaves, ER, Merrington, M. A note on the absence of “clustering” of multiple sclerosis cases. J Chron Dis 1973; 30: 217224.Google Scholar
25.Neutel, CI, Walter, SD, Mousseau, G. Clustering during childhood of multiple sclerosis patients. J Chron Dis 1977; 30: 217224.Google ScholarPubMed
26.Poskanzer, DC, Walker, AM, Prenney, LB, et al. The etiology of multiple sclerosis: temporal-spatial clustering indicating two environmental exposures before onset. Neurology 1981; 31: 708713.CrossRefGoogle ScholarPubMed
27.Kurtzke, JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983; 33: 14441452.Google ScholarPubMed
28.Caldwell, GC. Twenty-two years of cancer cluster investigations at the centers for disease control. Am J Epidemiol 1990; 132: S43-S47.CrossRefGoogle ScholarPubMed
29.Schottenfeld, D, Fraumeni, JF. Cancer epidemiology and prevention. W.B. Saunders 1982; 21: 391407.Google Scholar
30.Knox, G. Epidemiology of childhood leukemia in Northumberland and Durham. Brit J Prev Med 1964; 18: 1724.Google ScholarPubMed
31.Ederer, F, Myers, MH, Mantel, N. A statistical problem in space and time: do leukemia cases come in clusters? Biometrics 1964; 20: 626638.CrossRefGoogle Scholar
32.Barton, DE, David, FN, Merrington, M. A criterion for testing contagion in time and space. Ann Hum Genet (London) 1965; 29: 97102.CrossRefGoogle Scholar
33.Mantel, N. The detection of disease clustering and a generalized regression approach. Cancer Res 1967; 27: 209220.Google Scholar
34.Roberson, PK. Controlling for time-varying population distributions in disease clustering studies. Am J Epidemiol 1990; 132: S131-S135.Google ScholarPubMed
35.Breslow, NE, Day, NE. Statistical methods in cancer research. Vol 2: the design and analysis of cohort studies. Oxford: University Press 1988; 2: 4879.Google Scholar
36.Rothman, KJ. A sobering start for the cluster buster’s conference. Am J Epidemiol 1990; 132: S6-S13.CrossRefGoogle Scholar
37.Langmuir, AD. Epidemiology of cancer: spatial-temporal aggregation. Cancer Res 1965; 25: 13841386.Google ScholarPubMed