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Chronic (Rasmussen’s) Encephalitis in an Adult

  • Richard Wennberg (a1), Sukriti Nag (a2), Mary-Pat McAndrews (a3), Andres M. Lozano (a4), Richard Farb (a5) and David Mikulis (a5)...

Extract

A 24-year-old woman was referred because of incompletely-controlled complex partial seizures. Her seizures had started at age 21, after a mild head injury with brief loss of consciousness incurred in a biking accident, and were characterized by a sensation of bright flashing lights in the right visual field, followed by numbness and tingling in the right foot, spreading up the leg and to the arm, ultimately involving the entire right side, including the face. Occasionally they spread further to involve right facial twitching with jerking of the right arm and leg, loss of awareness and, at the onset of her epilepsy, rare secondarily generalized convulsions. Seizure frequency averaged three to four per month. She was initially treated with phenytoin and clobazam and subsequently changed to carbamazepine 800 milligrams per day. She also complained that her right side was no longer as strong as her left and that it was also numb, especially the leg, but felt that this weakness had stabilized or improved slightly over the past two years.

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References

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1. Oguni, H, Andermann, F, Rasmussen, TB. The syndrome of chronic encephalitis and epilepsy. A study based on the MNI series of 48 cases. Adv Neurol 1992;57:419433.
2. Hart, YM, Andermann, F, Fish, DR, et al. Chronic encephalitis and epilepsy in adults and adolescents: a variant of Rasmussen’s syndrome? Neurology 1997;48:418424.
3. Rogers, SW, Andrews, I, Gahring, LC, et al. Autoantibodies to glutamate receptor GluR3 in Rasmussen’s encephalitis. Science 1994;265:648651.
4. Hart, YM, Cortez, M, Andermann, F, et al. Medical treatment of Rasmussen’s syndrome (chronic encephalitis and epilepsy): effect of high-dose steroids or immunoglobulins in 19 patients. Neurology 1994;44:10301036.
5. Andrews, PI, Dichter, MA, Berkovic, SF, Newton, MR, McNamara, JO. Plasmapheresis in Rasmussen’s encephalitis. Neurology 1996;46:242246.

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Chronic (Rasmussen’s) Encephalitis in an Adult

  • Richard Wennberg (a1), Sukriti Nag (a2), Mary-Pat McAndrews (a3), Andres M. Lozano (a4), Richard Farb (a5) and David Mikulis (a5)...

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