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Cerebral Perfusion Pressure Targets in Traumatic Brain Injury: The “Fuzzy” Spots Above Optimal Cerebral Perfusion Pressure

  • Frederick A. Zeiler (a1) (a2)
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      Cerebral Perfusion Pressure Targets in Traumatic Brain Injury: The “Fuzzy” Spots Above Optimal Cerebral Perfusion Pressure
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Copyright

Corresponding author

Correspondence to: F. A. Zeiler, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Email:umzeiler@myumantioba.ca

References

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1. Thiara, S, Griesdale, DE, Henderson, WR, Sekhon, MS. Effect of cerebral perfusion pressure on acute respiratory distress syndrome. Can J Neurol Sci. 2018;45:313-319.
2. Carney, N, Totten, AM, O’Reilly, C, etal. Guidelines for the management of severe traumatic brain injury, fourth edition. Neurosurgery. 2017;80:6-15.
3. Aries, MJH, Czosnyka, M, Budohoski, KP, etal. Continuous determination of optimal cerebral perfusion pressure in traumatic braininjury. Crit Care Med. 2012;40:2456-2463.
4. Needham, E, McFadyen, C, Newcombe, V, Synnot, AJ, Czosnyka, M, Menon, D. Cerebral perfusion pressure targets individualized to pressure-reactivity index in moderate to severe traumatic brain injury: a systematicreview. J Neurotrauma. 2017; 34:963-970.
5. Czosnyka, M, Smielewski, P, Kirkpatrick, P, Laing, RJ, Menon, D, Pickard, JD. Continuous assessment of the cerebral vasomotor reactivity in headinjury. Neurosurgery. 1997;41:11-17; discussion 17-19.
6. Brady, KM, Lee, JK, Kibler, KK, etal. The lower limit of cerebral blood flow autoregulation is increased with elevated intracranial pressure. Anesth Analg. 2009;108:1278-1283.
7. Pesek, M, Kibler, K, Easley, RB, etal. The upper limit of cerebral blood flow autoregulation is decreased with elevations in intracranial pressure. Neurosurgery. 2014;75:163-170; discussion 169-170.
8. Lassen, NA. Cerebral blood flow and oxygen consumptionin man. Physiol Rev. 1959;39:183-238.
9. Zeiler, FA, Lee, JK, Smielewski, P, Czosnyka, M, Brady, K. Validation of ICP derived cerebrovascular reactivity indices against the lower limit of autoregulation. Part II: experimental model of arterial hypotension. J Neurotrauma, 2018. [Epub ahead of print].
10. Zeiler, FA, Donnelly, J, Calviello, L, etal. Validation of pressure reactivity and pulse amplitude indices against the lower limit of autoregulation. Part I: experimental intra-cranial hypertension. JNeurotrauma 2018[in press].
11. Steiner, LA, Czosnyka, M, Piechnik, SK, etal. Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic braininjury. Crit Care Med. 2002;30:733-738.

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Cerebral Perfusion Pressure Targets in Traumatic Brain Injury: The “Fuzzy” Spots Above Optimal Cerebral Perfusion Pressure

  • Frederick A. Zeiler (a1) (a2)

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