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Cerebral Evoked Potentials in Multiple Sclerosis

Published online by Cambridge University Press:  18 September 2015

Manouchehr Javidan ,
Donald R. McLean  and
Kenneth G. Warren
Manouchehr Javidan
Affiliation:
Division of Neurology, Department of Medicine, University of Alberta
Donald R. McLean*
Affiliation:
Division of Neurology, Department of Medicine, University of Alberta
Kenneth G. Warren
Affiliation:
Division of Neurology, Department of Medicine, University of Alberta
*
Division of Neurology, 9-101 Clinical Sciences Building, University of AlbertaEdmonton, Alberta, Canada T6G 2G3
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Abstract:

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Multimodal evoked potentials were analyzed from 58 possible, 62 probable and 100 definite (total 220) multiple sclerosis (MS) patients. Visual evoked potentials (VEP) were most frequently abnormal yielding 39%, 69%, 84% in the three diagnostic groups respectively. Median nerve sensory evoked potentials (SEP) yielded abnormalities in 26%, 65%, 79% respectively. Brainstem auditory evoked responses (BAER) were abnormal in 17%, 39%, 66% respectively. We measured the combined amplitude (CA) of waves III, IV, V in the BAER of these patients as an objective measure of amplitude asymmetry. The CA was considered abnormal if it was 1SD below the lowest CA value in the control group. The CA was abnormal in 9.2% of BAER with normal central conduction time. The BAER diagnostic yield in MS patients increased 11% by using CA analysis.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 3 , August 1986 , pp. 240 - 244
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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