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Trauma systems and emergency medical services: The missing link for tranexamic acid utilization in major trauma

  • John M. Tallon (a1) (a2) (a3)
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Copyright

Corresponding author

Correspondence to: Dr. John Tallon, 150 - 2955 Virtual Way, Vancouver, BC V5M 4X6; Email: john.tallon@bcehs.ca

References

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2. Parachute. The cost of injury in Canada; 2015. Available at: http://www.parachutecanada.org/research/item/economic-burden-of-injury-reports (accessed 29 January 2018).
3. Spinella, PC. Zero preventable deaths after traumatic injury: an achievable goal. J Trauma Acute Care Surg 2017;82(6S Suppl 1):S2-S8.
4. Public Health Agency of Canada. Table: leading causes of death, Canada, 2008, males and females combined, counts (age-specific death rate per 100,000); 2013. Available at: https://www.canada.ca/en/public-health/services/reports-publications/leading-causes-death-hospitalization-canada/2008-males-females-combined-counts-specific-death-rate.html (accessed 29 January 2018).
5. Public Health Agency of Canada. Table: leading causes of hospitalizations, Canada, 2008, males and females combined, counts (age-specific hospitalization rate per 100,000); 2013. Available at: https://www.canada.ca/en/public-health/services/reports-publications/leading-causes-death-hospitalization-canada.html (accessed 29 January 2018).
6. Cannon, JW. Hemorrhagic shock. N Engl J Med 2018;378(4):370-379; 10.1056/NEJMra1705649.
7. Ghawnni, A, Coates, A, Owen, J. Compliance of tranexamic acid administration to trauma patients at a level-one trauma centre. CJEM 2017;4:1-6.
8. CRASH-2 Trial Collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376(9734):23-32.
9. Morrison, JJ, Dubose, JJ, Rasmussen, TE, Midwinter, MJ. Military application of tranexamic acid in trauma emergency resuscitation (MATTERS) study. Arch Surg 2012;147(2):113-119.
10. Accreditation Canada. Trauma distinction. Available at: https://accreditation.ca/trauma-distinction/ (accessed 29 January 2018).
11. World Health Organization. WHO model list of essential medicines; 2017. Available at: http://www.who.int/medicines/publications/essentialmedicines/20th_EML2017_FINAL_amendedAug2017.pdf?ua=1 (accessed 29 January 2018).
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13. British Columbia Ambulance Service. Treatment guidelines: trauma management; 2016. Available at: https://bctg.bcas.ca/Condition/Interventions/16 (accessed 29 January 2018).
14. Vu, EN, Schlamp, RS, Wand, RT, et al. Prehospital use of tranexamic acid for hemorrhagic shock in primary and secondary air medical evacuation. Air Med J 2013;32(5):289-292.
15. London School of Hygiene & Tropical Medicine. CRASH-3. Available at: http://crash3.lshtm.ac.uk/ (accessed 29 January 2018).
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17. Gayet-Ageron, A, Prieto-Merino, D, Ker, K, et al; Antifibrinolytic Trials Collaboration. Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40,138 bleeding patients. Lancet 2018;391(10116):125-132; 10.1016/S0140-6736(17)32455-8.

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Trauma systems and emergency medical services: The missing link for tranexamic acid utilization in major trauma

  • John M. Tallon (a1) (a2) (a3)

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