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#Epi: There is no place for the use of intravenous epinephrine as a standard component of cardiac arrest resuscitation care

  • Michelle Welsford (a1) (a2), Jason E. Buick (a3), Ian R. Drennan (a4) (a5), Steve Lin (a3) (a5) and Paul R. Atkinson (a6)...
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Abstract

Copyright

Corresponding author

Correspondence to: Dr. Paul Atkinson, Department of Emergency Medicine, Dalhousie University, Saint John Regional Hospital, 400 University Ave., Saint John, NB, E2L 4L4; Email: paul.atkinson@dal.ca

References

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11.Olasveengen, TM, Sunde, K, Brunborg, C, et al. Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. JAMA 2009;302(20):2222–9.
12.Jacobs, IG, Finn, JC, Jelinek, GA, Oxer, HF, Thompson, PL. Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial. Resuscitation 2011;82(9):1138–43.
13.Nichol, G, Thomas, E, Callaway, CW, et al. Regional variation in out-of-hospital cardiac arrest incidence and outcome. JAMA 2008;300(12):1423–31.
14.Heart and Stroke Foundation of Canada. Position Statement on CPR: Heart and Stroke Foundation of Canada; 2016. Available at: https://resuscitation.heartandstroke.ca/guidelines/position/CPR (accessed March 17, 2019).
15.Neumar, RW, Nolan, JP, Adrie, C, et al. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 2008;118(23):2452–83.
16.Laver, S, Farrow, C, Turner, D, Nolan, J. Mode of death after admission to an intensive care unit following cardiac arrest. Intensive Care Med 2004;30(11):2126–8.
17.Callaway, CW, Soar, J, Aibiki, M, et al. Part 4: Advanced Life Support: 2015 International Consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation 2015;132(16 Suppl 1):S84145.
18.Gueugniaud, PY, Mols, P, Goldstein, P, et al. A comparison of repeated high doses and repeated standard doses of epinephrine for cardiac arrest outside the hospital. N Engl J Med 1998;339(22):1595–601.
19.Behringer, W, Kittler, H, Sterz, F, et al. Cumulative epinephrine dose during cardiopulmonary resuscitation and neurologic outcome. Ann Intern Med 1998;129(6):450–6.
20.Andersen, LW, Grossestreuer, AV, Donnino, MW. “Resuscitation time bias”-A unique challenge for observational cardiac arrest research. Resuscitation 2018;125:7982.
21.Glover, BM, Brown, SP, Morrison, L, et al. Wide variability in drug use in out-of-hospital cardiac arrest: a report from the resuscitation outcomes consortium. Resuscitation 2012;83(11):1324–30.
22.Hansen, M, Schmicker, RH, Newgard, CD, et al. Time to epinephrine administration and survival from nonshockable out-of-hospital cardiac arrest among children and adults. Circulation 2018;137(19):2032–40.
23.Nakahara, S, Tomio, J, Nishida, M, et al. Association between timing of epinephrine administration and intact neurologic survival following out-of-hospital cardiac arrest in Japan: a population-based prospective observational study. Acad Emerg Med 2012;19(7):782–92.
24.Tanaka, H, Takyu, H, Sagisaka, R, et al. Favorable neurological outcomes by early epinephrine administration within 19 minutes after EMS call for out-of-hospital cardiac arrest patients. Am J Emerg Med 2016;34(12):2284–90.
25.Andersen, LW, Kurth, T, Chase, M, et al. Early administration of epinephrine (adrenaline) in patients with cardiac arrest with initial shockable rhythm in hospital: propensity score matched analysis. BMJ 2016;353:i1577.
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Canadian Journal of Emergency Medicine
  • ISSN: -
  • EISSN: 1481-8035
  • URL: /core/journals/canadian-journal-of-emergency-medicine
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