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Relationships between some physical properties of insecticides and their inteinsic and contact toxicities to adult mosquitos (Anopheles stephensi List.)

Published online by Cambridge University Press:  10 July 2009

A. B. Hadaway
Affiliation:
Ministry of Overseas Development, Tropical Pesticides Research Unit, Porton

Extract

It had been noticed in earlier work that there was a lack of close relationship between the intrinsic and contact toxicities of various compounds to adults of Anopheles stephensi List., the intrinsic toxicities being determined by topical application of solutions and the contact toxicities by exposure to dry deposits. Since the reasons probably lay in the relative rates at which compounds penetrated the cuticle from solution and from the solid state, and since these rates are likely to be differently affected by the physical properties of the compounds, the intrinsic and contact toxicities to A. stephensi of some closely related carbamates and of a miscellaneous group of organophosphorus compounds were determined, together with the solubility in n-hexane and the partition coefficient between n-hexane and water of each, and the results were compared.

No definite pattern in the relationship between these physical properties of the compounds and their intrinsic and contact toxicities emerged from consideration of the results. However, there were indications that very low solubility is a limiting factor in the uptake and penetration into mosquitos of a solid insecticide and is associated with low contact toxicity, and that, when solubility is high enough to ensure solution in the wax layer of the cuticle, contact activity is favoured by a low value for the partition coefficient between hexane and water.

Type
Research Paper
Copyright
Copyright © Cambridge University Press 1966

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References

Hadaway, A. B. & Barlow, P. (1963). The influence of environmental conditions on the contact toxicity of some insecticide deposits to adult mosquitos, Anopheles stephensi List.—Bull. ent. Res. 54 pp. 329344.CrossRefGoogle Scholar
Hadaway, A. B. & Barlow, F. (in press). Evaluation of toxieity to adult mosquitos, Anopheles stephensi List, and the residual action of various chlorinated hydrocarbons, organophosphorus compounds and carbamates.—Bull. Wld Hlth Org.Google Scholar
Hansch, C. & Fujita, T. (1964). A method for the correlation of biological activity and chemical structure.—J. Am. chem. Soc. 86 pp. 16161626.CrossRefGoogle Scholar
Olson, W. P. & O'Brien, E. D. (1963). The relation between physical properties and penetration of solutes into the cockroach cuticle.—J. Insect Physiol. 9 pp. 777786.CrossRefGoogle Scholar
Treherne, J. E. (1957). The diffusion of non-electrolytes through the isolated cuticle of Schistocerca gregaria.—J. Insect Physiol. 1 pp. 178186.CrossRefGoogle Scholar

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