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Endocrine and physiological events from ovulation to establishment of pregnancy in cattle

Published online by Cambridge University Press:  27 February 2018

W.W. Thatcher ,
M. Binelli ,
D. Arnold ,
R. Mattos ,
L. Badinga ,
F. Moreira ,
C.R. Staples  and
A. Guzeloglu
W.W. Thatcher
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
M. Binelli
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
D. Arnold
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
R. Mattos
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
L. Badinga
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
F. Moreira
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
C.R. Staples
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
A. Guzeloglu
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
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Abstract

A series of in vitro and in vivo experiments were conducted to characterise the dialogue between embryo and maternal units relative to the mechanisms controlling embryo survival in dairy cattle. Endometrial explants from pregnant cows had an attenuated PGF2α secretory response following treatment with melittin (stimulator of PLA2) and phorbol 12, 13 dibutyrate (PDBu). Thus previous exposure to the conceptus appears to regulate the endometrial synthetic pathway at a point coincident with or distal to PLA2 as well as inhibit PKC or PKC mediated events. Endometrial explants collected from cows receiving intrauterine infusions of rblFN-τ had a reduced secretory response following stimulation with PDBu indicating attenuation in PKC activity. Based upon tyrosine-phosphorylation of STAT-proteins and their translocation to the nucleus after treatment with rbIFN-τ, the JAK-STAT pathway is functional in immortalised bovine endometrial cells (BEND cells). Bend cells, exposed to rblFN-τ, reduced PDBu induction of PGF2α secretion and also decreased protein expression of Cox-2 and PLA. RblFN-τ clearly reduced PKC mediated events leading to an antiluteolytic response in endometrial cells. Feeding diets containing 2.6, 5.2 and 7.8% Menhaden fish meal to lactating dairy cows reduced uterine secretion of PGF2α following sequential injections of oestradiol and oxytocin. Thus antiluteolytic effects in early pregnancy may be amplified by feeding by-pass fats. Pregnancy rate to a timed insemination at first service post-partum is increased in association with injection of bST(500 mg; sc) given at insemination. Furthermore injection of bST at time of insemination in superovulated donor cows increased the number of blastocysts and reduced number of unfertilised embryos. Prospects of integrating novel strategies to improve embryo development and survival into reproductive management systems appear to be attainable in high producing dairy cows.

Type
Invited Papers
Information
BSAP Occasional Publication , Volume 26 , Issue 1: Fertility in the High Producing Dairy Cow , January 2001 , pp. 81 - 91
Copyright
Copyright © British Society of Animal Science 2001

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References

Armstrong, J.D., Goodall, E.A., Gordon, F.J., Rice, D.A. and McCaughey, W.J. 1990. The effects of levels of concentrate offered and inclusion of maize gluten or fish meal in the concentrate on reproductive performance and blood parameters of dairy cows. Animal Production 50:1–10.Google Scholar
Ashes, J. R., Siebert, B.D., Gulati, S.K., Cuthbertson, Z.A. and Scott, T.W. 1992. Incorporation of n-3 fatty acids of fish oil into tissue and serum lipids of ruminants. Lipids 27:629–631.CrossRefGoogle ScholarPubMed
Austin, K.A., Ward, S.K., Teixeira, M.G., Dean, V.C., Moore, D.W. and Hansen, T.R. 1996. Ubiquitin cross-reactive protein is released by the bovine uterus in response to interferon during early pregnancy. Biology ofReproduction 54:600–606.CrossRefGoogle ScholarPubMed
Bartol, F.F., Roberts, R.M., Bazer, F.W., Lewis, G.S., Godkin, J.D. and Thatcher, W.W. 1985. Characterization of proteins produced in-vitro by peri-attachment bovine conceptuses. Biology of Reproduction. 32:681–694.CrossRefGoogle Scholar
Binelli, M., Diaz, T., Hansen, T.R. and Thatcher, W.W. 1998. Bovine interferon-tau induces phosphorylation and nuclear translocation of STAT-1, -2 and -3 in endometrial epithelial cells. Biology of Reproduction. 58(Suppl. 1):214 (Abstr.).Google Scholar
Binelli, M., Subramaniam, P.S. and Thatcher, W.W. 1996. Bovine interferon-tau promotes transient phosphorylation of STAT-1 protein in endometrium. Biology Reprod. 54(Suppl. 1): 169 (Abstr.).Google Scholar
Bruckental, I., Amir, S., Drori, D., Kaim, M., Lehrer, H. and Folman, Y. 1989. Effects of source and level of protein on milk yield and reproductive performance of high-producing primiparous and multiparous dairy cows. Animal Production. 48: 319–329.Google Scholar
Burke, J.M., Staples, C.R., Risco, C.A., De LaSota, R.L. and Thatcher, W.W. 1997. Effect of ruminant grade Menhaden fish meal on reproductive and productive performance of lactating dairy cows. Journal of Dairy Science. 80:3386–3398.CrossRefGoogle ScholarPubMed
Danet-Desnoyers, G., Wetzels, C. and Thatcher, W.W. 1994. Natural and recombinant bovine interferont regulate basal and oxytocin-induced secretion of prostaglandins F2a and E2 by epithelial cells and stromal cells in the endometrium. Reproduction. Fertility Development 6:193–202.CrossRefGoogle Scholar
Farin, C.E., Imakawa, K., Hansen, T.R., McDonnell, , Murphy, C.N., Farin, P.W. and Roberts, R.M. 1990. Expression of trophoblastic interferon genes in sheep and cattle. Biology of Reproduction. 43:210–218.CrossRefGoogle ScholarPubMed
Helmer, S.D., Hansen, P.J., Anthony, R.V., Thatcher, W.W., Bazer, F.W. and Roberts, R.M. 1987. Identification of bovine trophoblast protein-1, a secretory protein immunologically related to ovine trophoblast protein-1. Journal of Reproduction and Fertility. 79:83–91.CrossRefGoogle ScholarPubMed
Helmer, S.D., Hansen, P.J., Thatcher, W.W., Johnson, J.W. and Bazer, F.W. 1989. Intrauterine infusion of highly enriched bovine trophoblast protein-1 complex exerts an antiluteolytic effect to extend corpus luteum lifespan in cyclic cattle. Journal ofReproduction and Fertility. 87:89–101.CrossRefGoogle ScholarPubMed
Izadyar, F., Colenbrander, B. and Bevers, M.M. 1996. In vitro maturation of bovine oocytes in the presence of growth hormone accelerates nuclear maturation and promotes subsequent embryonic development. Molecular Reproduction Development 45:372–377.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Izadyar, F., Haje, W.J., Colenbrander, B. and Bevers, M.M. 1998. The promotory effect of growth hormone on the developmental competence of in vitro matured bovine oocytes is due to improved cytoplasmic maturation. Molecular Reproduction Development. 49:444–453.3.0.CO;2-U>CrossRefGoogle ScholarPubMed
Li, J. and Roberts, R.M. 1994. Interferon-t and interferon-a interact with the same receptors in the bovine enndometrium. Journal of Biological Chemistry. 269:13544–13550.CrossRefGoogle Scholar
Meyer, M.D., Hansen, P.J., Thatcher, W.W., Drost, M., Badinga, L., Roberts, R.M., Li, J., Ott, T.L. and Bazer, F.W. 1995. Extension of corpus luteum lifespan and reduction of uterine secretion of prostaglandin F^ of cows in response to recombinant interferon-t. Journal ofDairy Science 78:1921–1931.Google Scholar
Moreira, F., Risco, C, Pires, M.F.A., Ambrose, J.D., Drost, M. and Thatcher, W.W. 1997. Use of timed insemination in lactating dairy cows receiving bovine somatotropin. Journal ofDairy Science. 80 (Suppl.1):239. (Abstr.).Google Scholar
Moreira, F., Orlandi, C, Risco, C.A., Mattos, R., Lopes, F.L. and Thatcher, W.W. 1999. Effects of pre-synchronization and bST treatment on pregnancy rates to a timed artificial insemination protocol in lactating dairy cows. Journal ofAnimal Science 77 (Suppl. 1) 222 (Abstract).Google Scholar
Oldick, B.S., Staples, C.R., Thatcher, W.W. and Gyawu, P. 1997. Abomasal infusion of glucose and fat-effect on digestion, production, and ovarian and uterine functions of cows. Journal of Dairy Science. 80:1315–1328.CrossRefGoogle ScholarPubMed
Pace-Asciak, C. and Wolfe, L.S. 1968. Inhibition of prostaglandin synthesis by oleic, linoleic and linolenic acids. Acta Biochemistry. Biophysics 152:784–787.Google Scholar
Risco, C.A., Drost, M., Archbald, L., Moreira, F., de la Sota, R.L., Burke, J., and Thatcher, W.W. 1998. Timed artificial insemination in dairy cattle-Part I. Compendium of Continuous. Educationfor the Practicing Veterinarian. Vet. 20: S280–S287.Google Scholar
Smith, W.L., Marnett, L.J. and DeWitt, D.L. 1991. Prostaglandin and thromboxane biosynthesis. Pharmacological. Theiogenology. 49:153–179.Google ScholarPubMed
Thatcher, W.W., Binelli, M., Burke, J., Staples, C.R., Ambrose, J.D. and Coelho, S. 1997. Antiluteolytic signals between the conceptus and the endometrium. Theriogenology 47:131–140.CrossRefGoogle Scholar
Thatcher, W.W., Meyer, M.D. and Danet-Desnoyers, G. 1995. Maternal recognition of pregnancy. Journal of Reproduction and Fertility. 49:15–28.Google ScholarPubMed
Thatcher, W.W., Staples, C.R., Danet-Desnoyers, G., Oldick, B., Schmitt, E.-P. 1994. Embryo health and mortality in sheep and cattle. Journal of Animal Science. 72(Suppl 3): 16–30.CrossRefGoogle Scholar
Xiao, C.W., Murphy, B.D., Sirois, J. and Goff, A.K. 1999. Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-t in bovine endometrial cells. Biology of Reproduction 60:656–663.CrossRefGoogle Scholar