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Treatment with Selemax®, a selenium-enriched yeast, ameliorates experimental arthritis in rats and mice

  • Angélica T. Vieira (a1), Kátia D. Silveira (a1), Maria C. C. Arruda (a1), Caio T. Fagundes (a1), Juliana L. Gonçalves (a1), Tarcília A. Silva (a2), Maria J. Neves (a3), Maria A. B. C. Menezes (a3), Jacques R. Nicoli (a4), Mauro M. Teixeira (a1) and Flaviano S. Martins (a1) (a4)...

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly targets the synovial membrane, cartilage and bone. It affects 1 % of the population and is associated with significant morbidity and increased mortality. Se is an essential trace element with antioxidant properties and the ability to modulate the immune responses. Selemax® is an inactive yeast (Saccharomyces cerevisiae) enriched with organic Se. The aim of the present study was to investigate the effects of Selemax® administration in models of an antigen-induced arthritis (AIA) in C57BL/6 mice, and of an adjuvant-induced arthritis (AdIA) in Holtzman rats. As control, the animals were treated with the same inactivated yeast species that was not enriched for Se. In the AIA model, treatment with different doses of Selemax® (0·01, 0·1, 1 and 10 % added to food) significantly decreased the number of inflammatory cells recruited to the knee cavity, essentially by reducing the number of neutrophils. Levels of proinflammatory cytokines, including TNF-α, IL-1β and chemokine (C-X-C motif) ligand 1/keratinocyte chemoattractant (CXCL1/KC), were also reduced in the peri-articular tissue of mice treated with Selemax® at the tested dose (1 %). In the AdIA model in rats, Selemax® treatment decreased paw oedema and hypernociception. This reduction was associated with inhibition of the influx of proinflammatory cells. Therefore, treatment with Selemax® is associated with amelioration of several inflammatory and functional parameters in models of arthritis, suggesting that this Se-enriched yeast should be evaluated further in patients with RA.

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Corresponding author

*Corresponding author: Professor F. S. Martins, fax +55 31 3409 2730, email flaviano@icb.ufmg.br

References

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1Firestein, GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423, 356361.
2Feldmann, M, Brennan, FM & Maini, RN (1996) Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14, 397440.
3Arend, WP (2001) Physiology of cytokine pathways in rheumatoid arthritis. Arthritis Rheum 45, 101106.
4Smolen, JS & Steiner, G (2003) Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov 2, 473488.
5Mirshafiey, A & Mohsenzadegan, M (2008) The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis. J Allergy Asthma Immunol 4, 195202.
6Tayar, JH & Suarez-Almazor, ME (2010) New understanding and approaches to treatment in rheumatoid arthritis. Br Med Bull 94, 201214.
7Rayman, MP (2000) The importance of selenium to human health. Lancet 356, 233241.
8Gärtner, R (2009) Selenium and thyroid hormone axis in critical ill states: an overview of conflicting view points. J Trace Elem Med Biol 23, 7174.
9Parnham, MJ, Winkelmann, J & Leyck, S (1983) Macrophage, lymphocyte and chronic inflammatory responses in selenium deficient rodents. Association with decreased glutathione peroxidase activity. Int J Immunopharmacol 5, 455461.
10Peretz, A, Siderova, V & Néve, J (2001) Selenium supplementation in rheumatoid arthritis investigated in a double blind, placebo controlled trial. Scand J Rheumatol 30, 208212.
11COBEA. Colegio Brasileiro de Experimentação Animal (2006) Legislação e Ética. http://www.cobea.org.br/.
12Coelho, FM, Pinho, V, Amaral, FA, et al. (2008) The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. Arthritis Rheum 8, 23292337.
13Francischi, JN, Yokoro, CM, Poole, S, et al. (2000) Anti-inflammatory and analgesic effects of the phosphodiesterase 4 inhibitor rolipram in a rat model of arthritis. Eur J Pharmacol 399, 243249.
14Vieira, AT, Pinho, V, Lepsch, LB, et al. (2005) Mechanisms of the anti-inflammatory effects of the natural secosteroids physalins in a model of intestinal ischaemia and reperfusion injury. Br J Pharmacol 146, 244251.
15Menezes, MABC & Jacimovic, R (2006) Optimised k0-intrumental neutron activation method using the TRIGA MARK I IPR-R1 reactor at CDTN/CNEN, Belo Horizonte, Brazil. Nucl Instrum Methods Phys Res 564, 707715.
16Tatsuo, MA, Carvalho, WM, Silva, CV, et al. (1994) Analgesic and anti-inflammatory effects of dipyrone in rat adjuvant arthritis model. Inflammation 18, 399405.
17Francischi, JN, Pereira, LS & Castro, MS (1997) Cyclosporin inhibits hyperalgesia and edema in arthritic rats: role of the central nervous system. Braz J Med Biol Res 30, 101111.
18Arthur, JR, McKenzie, RC & Beckett, GJ (2003) Selenium in the immune system. J Nutr 133, 14571459.
19Firestein, GS (2006) Inhibiting inflammation in rheumatoid arthritis. N Engl J Med 354, 8082.
20Grespan, R, Fukada, SY, Lemos, HP, et al. (2008) CXCR2-specific chemokines mediate leukotriene B4-dependent recruitment of neutrophils to inflamed joints in mice with antigen-induced arthritis. Arthritis Rheum 58, 20302040.
21Barsante, MM, Cunha, TM, Allegretti, M, et al. (2008) Blockade of the chemokine receptor CXCR2 ameliorates adjuvant-induced arthritis in rats. Br J Pharmacol 153, 9921002.
22Russo, RC, Garcia, CC & Teixeira, MM (2010) Anti-inflammatory drug development: Broad or specific chemokine receptor antagonists? Curr Opin Drug Discov Devel 13, 414427.
23Gabay, C & McInnes, IB (2009) The biological and clinical importance of the ’new generation’ cytokines in rheumatic diseases. Arthritis Res Ther 11, 230.
24O'Dell, JR, Lemley-Gillespie, S, Palmer, WR, et al. (1991) Serum selenium concentrations in rheumatoid arthritis. Ann Rheum Dis 50, 376378.
25Aaseth, J, Haugen, M & Førre, O (1998) Rheumatoid arthritis and metal compounds – perspectives on the role of oxygen radical detoxification. Analyst 123, 36.
26Prokopová, A, Kéry, V, Stancíková, M, et al. (1993) Methyl-α-d-mannopyranoside, manno-oligosaccharides and yeast mannans inhibit development of rat adjuvant arthritis. J Rheumatol 20, 673677.
27Kilpatrick, DC (2003) Introduction to mannan-binding lectin. Biochem Soc Trans 31, 745747.
28Drábiková, K, Perecko, T, Nosál, R, et al. (2009) Glucomannan reduces neutrophil free radical production in vitro and in rats with adjuvant arthritis. Pharmacol Res 59, 399403.
29Seko, Y & Imura, N (1997) Active oxygen generation as a possible mechanism of selenium toxicity. Biomed Environ Sci 10, 333339.
30Vunta, H, Davis, F, Palempalli, UD, et al. (2007) The anti-inflammatory effects of selenium are mediated through 15-deoxy-δ 12,14-prostaglandin J2 in macrophages. J Biol Chem 282, 1796417973.
31Roebuck, KA (1999) Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB. Int J Mol Med 3, 223230.
32Prabhu, KS, Zamamiri-Davis, F, Stewart, JB, et al. (2002) Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264·7 macrophages: role of nuclear factor-κB in up-regulation. Biochem J 366, 203209.
33Zamamiri-Davis, F, Lu, Y, Thompson, JT, et al. (2002) Nuclear factor-κB mediates over-expression of cyclooxygenase-2 during activation of RAW 264.7 macrophages in selenium deficiency. Free Radic Biol Med 32, 890897.

Keywords

Treatment with Selemax®, a selenium-enriched yeast, ameliorates experimental arthritis in rats and mice

  • Angélica T. Vieira (a1), Kátia D. Silveira (a1), Maria C. C. Arruda (a1), Caio T. Fagundes (a1), Juliana L. Gonçalves (a1), Tarcília A. Silva (a2), Maria J. Neves (a3), Maria A. B. C. Menezes (a3), Jacques R. Nicoli (a4), Mauro M. Teixeira (a1) and Flaviano S. Martins (a1) (a4)...

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