Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-23T14:11:06.983Z Has data issue: false hasContentIssue false
  • English
  • Français

Short-term dietary selenium restriction in young adults: quantitative studies with the stable isotope 74SeO32−

Published online by Cambridge University Press:  09 March 2007

Lynda J. Kasper ,
Vernon R. Young  and
Morteza Janghorbani
Lynda J. Kasper
Affiliation:
Laboratory of Human Nutrition, Department of Nutrition and Food Science, Cambridge, Massachusetts 02139, USA
Vernon R. Young
Affiliation:
Laboratory of Human Nutrition, Department of Nutrition and Food Science, Cambridge, Massachusetts 02139, USA
Morteza Janghorbani
Affiliation:
Laboratory of Human Nutrition, Department of Nutrition and Food Science, Cambridge, Massachusetts 02139, USA Nuclear Reactor Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. A 45 d metabolic study was carried out in four young adult male North American residents consuming a controlled diet based on an amino acid mixture. During the initial 10 d, total daily selenium intake was adjusted to 107.7 (SE 0.1) μg/d, which was reduced to 11.4 (SE 0.1) μg/d for the remaining 35 d.

2. Two doses of a stable isotope (74SeO32-) were administered orally in the post-absorptive state on days 4 and 39 of the study.

3. Se balance (faecal + urinary excretion) as well as stable isotope excretion studies were carried out for the entire 45 d period; blood plasma and erythrocyte Se concentrations were also monitored.

4. Plasma Se concentrations (μg/ml) fell progressively from the initial value of 0.132 (SE 0.007) to 0.083 (SE 0.008) at the end of the study. The erythrocyte concentrations of Se did not vary in a consistent manner (average value for the entire study 0.147 (SE 0.002) μg/ml).

5. Faecal excretion of unenriched Se decreased from 66 (SE 6) μg/d for days 1–10 to 10.2 (SE 0.8) μg/d for days 14–40. Mean urinary excretions of the unenriched Se were 43.9 (SE 2.8) μg/d (days 1–10) and 26.9 (SE 4.6) μg/d (days 14–40). Total balance (intake - faecal excretion - urinary excretion) for unenriched Se was μg/d):-18 (SE 7) days 10–19, -17 (SE 2) days 19–39, -5 (SE 1) days 38–45.

6. Fractional absorption of the ingested label was 0.529 (SE 0.032) and 0.542 (SE 0.038) for the Se-adequate and Se-restricted phases of the study. However, urinary excretion of the absorbed label was reduced from 6.57 (SE 0.73)% for day 1 of the Se-adequate phase to only 3.32 (SE 0.26)% for day 1 of the Se-restricted phase. Similar observations were also made for day 7 of each phase.

7. These findings indicate that immediate contribution of ingested Se to the urinary Se pool is small.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 52 , Issue 3 , November 1984 , pp. 443 - 455
Copyright
Copyright © The Nutrition Society 1984

References

REFERENCES

Chen, Xi, Chen, Xu, Yang, G., Wen, Z., Chen, J. & Ge, K. (1981). In Selenium in Biology and Medicine, pp. 171–175 [Spallholz, J. E., Martin, J. L. and Ganter, H. E., editors]. Westport, CT, USA: AVI Publishing Co.Google Scholar
Christensen, M. J. (1982). Application of stable isotope in the study of selenium bioavailability in man. PhD Thesis, Massachusetts Institute of Technology.Google Scholar
Dickson, R. C. & Tomlinson, R. N. (1967). Clinical Chimica Acta 16, 311–321.CrossRefGoogle Scholar
Janghorbani, M., Christensen, M. J., Nahapetian, A. & Young, V. R. (1981 a). American Journal of Clinical Nutrition 35, 647–654.CrossRefGoogle Scholar
Janghorbani, M., Kasper, L. J. & Young, V. R. (1984). American Journal of Clinical Nutrition (In the Press).Google Scholar
Janghorbani, M., Ting, B. T. G., Nahapetian, A. & Young, V. R. (1982). Analytical Chemistry 54, 1188–1190.CrossRefGoogle Scholar
Janghorbani, M., Ting, B. T. G. & Young, V. R. (1981 b). American Journal of Clinical Nutrition 34, 2816–2830.CrossRefGoogle Scholar
Jereb, M., Falk, R., Jereb, B & Lindhe, C. (1975). Journal of Nuclear Medicine 16, 846–850.Google Scholar
Lederer, C. M., Hollander, J. M. & Perlman, I. (1967). Table of Isotopes, 6th ed. New York: John Wiley and Sons, Inc.Google Scholar
Levander, O. A., Sutherland, B., Morris, V. C. & King, J. C. (1981). American Journal of Clinical Nutrition 34, 2662–2669.CrossRefGoogle Scholar
Lutwak, L. (1969). American Journal of Clinical Nutrition 22, 771–785.CrossRefGoogle Scholar
Schroeder, H. A., Frost, D. V. & Balassa, J. J. (1970). Journal of Chronic Disease 23, 227–243.CrossRefGoogle Scholar
Stewart, R. D. H., Griffiths, N. M., Thomson, C. D. & Robinson, M. F. (1978). British Journal of Nutrition 40, 45–54.CrossRefGoogle Scholar
Swanson, C. A., Reamer, D. C., Veillon, C., King, J. C. & Levander, O. A. (1983). American Journal of Clinical Nutrition 38, 169–180.CrossRefGoogle Scholar
Thomson, C. D. & Robinson, M. F. (1980). American Journal of Clinical Nutrition 33, 302–323.Google Scholar
Tonsirin, K., Young, V. R., Miller, M. & Scrimshaw, N. S. (1973). Journal of Nutrition 103, 1220–1228.CrossRefGoogle Scholar
Young, V. R., Nahapetian, A. & Janghorbani, M. (1982). American Journal of Clinical Nutrition 35, 1076–1088.CrossRefGoogle Scholar