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Retinol transport proteins and concentrations in human amniotic fluid, placenta, and fetal and maternal sera

Published online by Cambridge University Press:  24 July 2007

D. Sklan ,
I. Shalit ,
N. Lasebnik ,
Z. Spirer  and
Y. Weisman
D. Sklan
Affiliation:
Faculty of Agriculture, Israel
I. Shalit
Affiliation:
Departments of Pediatrics, and Obstetrics and Gynaecology, Tel Aviv Medical Center, Tel Aviv University, Sackler Medical School, Tel Aviv, Israel
N. Lasebnik
Affiliation:
Departments of Pediatrics, and Obstetrics and Gynaecology, Tel Aviv Medical Center, Tel Aviv University, Sackler Medical School, Tel Aviv, Israel
Z. Spirer
Affiliation:
Departments of Pediatrics, and Obstetrics and Gynaecology, Tel Aviv Medical Center, Tel Aviv University, Sackler Medical School, Tel Aviv, Israel
Y. Weisman
Affiliation:
Departments of Pediatrics, and Obstetrics and Gynaecology, Tel Aviv Medical Center, Tel Aviv University, Sackler Medical School, Tel Aviv, Israel
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Abstract

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1. The proteins binding retinol, and retinol concentrations, were determined in amniotic fluid, placental cytosol and in the fetal and maternal circulation.

2. In non-pregnant women, plasma retinol was almost exclusively found in a transthyretin-retinol-binding-protein complex whereas, in pregnant women, retinol-binding-protein-bound retinol was observed not complexed to transthyretin. This latter fraction increased in concentration with fetal age. These two fractions were the major retinol-protein complexes in amniotic fluid and their relative amounts changed with progress of gestation.

3. In fetal blood both of these fractions were again found, with higher proportions of retinol-binding- protein-bound retinol in the umbilical artery than in the umbilical vein.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 3 , November 1985 , pp. 577 - 583
Copyright
Copyright © The Nutrition Society 1985

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