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The relationship between iodine nutrition and thyroid disease in lactating women with different iodine intakes

  • Lixiang Liu (a1), Dandan Wang (a1), Peng Liu (a1), Fangang Meng (a1), Da Wen (a1), Qingzhen Jia (a2), Jun Liu (a3), Xiaoye Zhang (a1), Peng Jiang (a1) and Hongmei Shen (a1)...

Abstract

Areas with low, adequate and excessive I content in water co-exist in China. Limited data are currently available on I nutrition and thyroid disease in lactating women and their breast-fed infants with different I intakes. This study aimed to evaluate I nutrition in both lactating women and their infants and the prevalence of thyroid disease in areas with different levels of I in water. From January to June 2014, a total of 343 healthy lactating women (excluding those taking anti-thyroid drugs or I supplements within a year of the study, consuming seafood at the time of the study or those diagnosed with congenital thyroid disease) from Beihai in Guangxi province and Jiajiazhuang, Yangcheng, Jicun and Pingyao townships in Shanxi province were selected. Compared with the I-sufficient group, median urinary I concentrations in both lactating women and infants as well as breast milk I levels were significantly lower in the I-deficient group (P<0·001). The prevalence of thyroid disease in lactating women, particularly subclinical hypothyroidism, was higher in the I-excess group than in the I-sufficient group (P<0·05). In areas with excessive water I content, high thyroid peroxidase antibody and high thyroglobulin levels were risk factors for abnormal thyroid-stimulating hormone levels. Our data collectively suggest that excessive I intake potentially causes subclinical hypothyroidism in lactating women. Moreover, enhanced monitoring of I status is important to avoid adverse effects of I deficiency or excess, particularly in susceptible populations such as pregnant or lactating women and infants.

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Corresponding author

* Corresponding author: H. Shen, fax +86 451 866 57674, email shenhm119@126.com

References

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1. Hetzel, BS, Potter, BJ & Dulberg, EM (1990) The iodine deficiency disorders: nature, pathogenesis and epidemiology. World Rev Nutr Diet 62, 59119.
2. WHO/UNICEF/ICCIDD (2007) Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination, A Guide For Program Managers, 3rd ed. Geneva: WHO, WHO/NDH/ 01.1.
3. Melse-Boonstra, A & Jaiswal, N (2010) Iodine deficiency in pregnancy, infancy and childhood and its consequences for brain development. Best Pract Res ClinEndocrin Metab 24, 2938.
4. Dorea, JG (2002) Iodine nutrition and breast feeding. J Trace Elem Med Biol 16, 207220.
5. Liu, P, Liu, L, Shen, H, et al. (2014) The standard, intervention measures and health risk for high water iodine areas. PLOS ONE 9, e89608.
6. Chung, HR, Shin, CH, Yang, SW, et al. (2009) Subclinical hypothyroidism in Korean preterm infants associated with high levels of iodine in breast milk. J Clin Endocrinol Metab 94, 44444447.
7. Shen, H, Liu, S, Sun, D, et al. (2011) Geographical distribution of drinking-water with high iodine level and association between high iodine level in drinking-water and goitre: a Chinese national investigation. Br J Nutr 106, 243247.
8. Sun, D, Xiao, D & Liu, S (2011) The Monitoring of Iodine Deficiency Disorders of China in 2011. Beijing: People’s Medical Publishing House.
9. Shen, H, Sui, X, Ge, X, et al. (2009) Delimitation for the Endemic Areas of Iodine Deficiency Disorders (IDD). Beijing: National Standard of China, GB 16005-2009.
10. Liu, D, Zhao, J, Zhu, H, et al. (2003) Determination and Classification of the Areas of High Water Iodine and the Endemic Areas of Iodine Excess Goiter. Beijing: National Standard of China, GB/T1 9380-2003.
11. Yan, Y, Zhang, Y, Liu, L, et al. (2006) Method for Determination of Iodine in Urine By As 3+ –Ce 4+ Catalytic Spectrophotometry . Beijing: Health Standard of China, WS/T 107-2006.
12. Tong, Y & Huo, J (2012) General Test Method in Salt Industry – Determination of Iodine. Beijing: National Standard of China. GB/T 13025.7-2012.
13. Liu, L, Li, S, Li, X, et al. (2008) Method for Determination of Iodine in Foodstuff by As(III)-Ce 4+ Catalytic Spectrophotometry . Beijing: Health Standard of China. WS 302-2008.
14. Liu, S, Chen, Z, Jia, Q, et al. (2007) Diagnostic Criterion of Endemic Goiter. Beijing: Health Standard of China, WS 276-2007.
15. Laurberg, P, Andersen, S, Knudsen, N, et al. (2002) Thiocyanate in food and iodine in milk: from domestic animal feeding to improved understanding of cretinism. Thyroid 12, 897902.
16. Yan, YQ, Chen, ZP, Yang, XM, et al. (2005) Attention to the hiding iodine deficiency in pregnant and lactating women after universal salt iodization: a multi-community study in China. J Endocrinol Invest 28, 547553.
17. Yu, J, Liu, P, Shen, H, et al. (2011) The inhabitant’s iodine nutrition status of some coastal areas in China: a cross-sectional study. Chin J Endemiolog 30, 594597.
18. Laurberg, P, Pedersen, KM, Hreidarsson, A, et al. (1998) Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. J Clin Endocrinol Metab 83, 765769.
19. The State Council of the People’s Republic of China (1994) Control Iodised Salt Management Regulations for IDD. Beijing: SCPRC (in Chinese).
20. Neville, MC, Keller, R, Seacat, J, et al. (1988) Studies in human lactation: milk volumes in lactating women during the onset of lactation and full lactation. Am J Clin Nutr 48, 13751386.
21. Delange, F (2007) Iodine requirements during pregnancy, lactation and the neonatal period and indicators of optimal iodine nutrition. Public Health Nutr 10, 15711580.
22. Semba, RD & Delange, F (2001) Iodine in human milk: perspectives for infant health. Nutr Rev 59, 269278.
23. Wang, Y, Zhang, Z, Ge, P, et al. (2009) Iodine status and thyroid function of pregnant, lactating women and infants (0–1yr) residing in areas with an effective Universal Salt Iodization program. Asia Pac J Clin Nutr 18, 3440.
24. Caldwell, KL, Jones, R & Hollowell, JG (2005) Urinary iodine concentration: United States National Health and Nutrition Examination Survey 2001–2002. Thyroid 15, 692699.
25. Wang, W, Jin, Y, Teng, W, et al. (2002) Research of epidemiology of serum TSH levels of healthy people in area with different iodine intake in China. Chin J Endocrinol Metab 18, 355356.
26. Azizi, F & Smyth, P (2009) Breastfeeding and maternal and infant iodine nutrition. Clin Endocrinol (Oxf) 70, 803809.
27. Meng, F, Zhao, R, Liu, P, et al. (2013) Assessment of iodine status in children, adults, pregnant women and lactating women in iodine-replete areas of China. PLOS ONE 8, e81294.
28. Ma, ZF & Skeaff, SA (2014) Thyroglobulin as a biomarker of iodine deficiency: a review. Thyroid 24, 11951209.
29. Zimmermann, MB, Aeberli, I, Andersson, M, et al. (2013) Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 μg//L: a UNICEF/ICCIDD study group report. J Clin Endocrinol Metab 98, 12711280.
30. Teng, W, Shan, Z, Teng, X, et al. (2006) Effect of iodine intake on thyroid diseases in China. N Engl J Med 354, 27832793.
31. Sang, ZN, Wei, W, Zhao, N, et al. (2012) Thyroid dysfunction during late gestation is associated with excessive iodine intake in pregnant women. J Clin Endocrinol Metab 97, E1363E1369.

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