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Accepted manuscript

Preconception Paternal/Maternal Body Mass Index and Risk of Small/Large for Gestational Age Infant in over 4·7 Million Chinese Women Aged 20-49 Years: A Population-based Cohort Study in China

Published online by Cambridge University Press:  21 February 2022

Tonglei GUO
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China
Ying YANG*
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China Graduate School of Peking Union Medical College, Building 18, No.9, Dongdan Santiao, Dongcheng District, 100730 Beijing, China
Jiajing JIA
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China Graduate School of Peking Union Medical College, Building 18, No.9, Dongdan Santiao, Dongcheng District, 100730 Beijing, China
Yuzhi DENG
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China Graduate School of Peking Union Medical College, Building 18, No.9, Dongdan Santiao, Dongcheng District, 100730 Beijing, China
Yuanyuan WANG
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China
Ya ZHANG
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China
Hongguang ZHANG
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China
Yuan HE
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China Graduate School of Peking Union Medical College, Building 18, No.9, Dongdan Santiao, Dongcheng District, 100730 Beijing, China
Jun Zhao
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China
Zuoqi PENG
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China
Qiaomei WANG
Affiliation:
Department of Maternal and Child Health, National Health Commission of the PRC, No.1, Xizhimenwai South Road, Xicheng District, 100044 Beijing, China
Haiping SHEN
Affiliation:
Department of Maternal and Child Health, National Health Commission of the PRC, No.1, Xizhimenwai South Road, Xicheng District, 100044 Beijing, China
Yiping ZHANG
Affiliation:
Department of Maternal and Child Health, National Health Commission of the PRC, No.1, Xizhimenwai South Road, Xicheng District, 100044 Beijing, China
Donghai YAN
Affiliation:
Department of Maternal and Child Health, National Health Commission of the PRC, No.1, Xizhimenwai South Road, Xicheng District, 100044 Beijing, China
Xu MA*
Affiliation:
National Research Institute for Family Planning, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, 100081 Beijing, China Graduate School of Peking Union Medical College, Building 18, No.9, Dongdan Santiao, Dongcheng District, 100730 Beijing, China
*
*Correspondence: Ying YANG, PhD, Email: angela-yy65@hotmail.com; fax +86 10 62179059, National Research Institute for Family Planning, National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, Beijing 100081, China, Telephone: 8610-18911389268, OR Professor Xu Ma, MS, Email: nfpcc_ma@163.com; fax +86 371 67781869, National Research Institute for Family Planning, National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, Beijing 100081, China, Telephone: 86-62179059
*Correspondence: Ying YANG, PhD, Email: angela-yy65@hotmail.com; fax +86 10 62179059, National Research Institute for Family Planning, National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, Beijing 100081, China, Telephone: 8610-18911389268, OR Professor Xu Ma, MS, Email: nfpcc_ma@163.com; fax +86 371 67781869, National Research Institute for Family Planning, National Human Genetic Resource Center, No.12, Dahuisi Road, Haidian District, Beijing 100081, China, Telephone: 86-62179059
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Abstract

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Evidence of couples’ BMI and its influence on birth weight is limited and contradictory. Therefore, this study aims to assess the association between couple’s preconception BMI and the risk of small for gestational age (SGA)/large for gestational age (LGA) infant, among over 4·7 million couples in a retrospective cohort study based on the National Free Pre-pregnancy Checkups Project (NFPCP) between December 1, 2013 and November 30, 2016 in China. Among the live births, 256,718 (5·44%) SGA events and 506,495 (10·73%) LGA events were documented, respectively. After adjusting for confounders, underweight men had significantly higher risk [OR 1·17 95%CI (1·15-1·19)] of SGA infants compared with men with normal BMI, while a significant and increased risk of LGA infants was obtained for overweight and obese men [OR 1·08 (95% CI: 1·06-1·09); OR 1·19 (95%CI 1·17-1·20)] respectively. The restricted cubic spline (RCS) result revealed a non-linearly decreasing dose-response relationship of paternal BMI (less than 22·64) with SGA. Meanwhile, a non-linearly increasing dose-response relationship of paternal BMI (more than 22·92) with LGA infants was observed. Moreover, similar results about the association between maternal preconception BMI and SGA/LGA infants were obtained. Abnormal preconception BMIs in either women or men were associated with increased risk of SGA/LGA infants, respectively. Overall, couple’s abnormal weight before pregnancy may be an important preventable risk factor for SGA/LGA infants.

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© The Authors 2022

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These authors contributed equally as corresponding authors to the paper.

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Preconception Paternal/Maternal Body Mass Index and Risk of Small/Large for Gestational Age Infant in over 4·7 Million Chinese Women Aged 20-49 Years: A Population-based Cohort Study in China
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Preconception Paternal/Maternal Body Mass Index and Risk of Small/Large for Gestational Age Infant in over 4·7 Million Chinese Women Aged 20-49 Years: A Population-based Cohort Study in China
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Preconception Paternal/Maternal Body Mass Index and Risk of Small/Large for Gestational Age Infant in over 4·7 Million Chinese Women Aged 20-49 Years: A Population-based Cohort Study in China
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