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Plasma magnesium and the risk of new-onset hyperuricaemia in hypertensive patients

  • Jingjing Cao (a1) (a2), Jingping Zhang (a2), Yuanyuan Zhang (a3), Huan Li (a3), Chongfei Jiang (a3), Tengfei Lin (a1), Ziyi Zhou (a1), Yun Song (a1) (a2), Chengzhang Liu (a4), Lishun Liu (a1), Binyan Wang (a2), Jianping Li (a5), Yan Zhang (a5), Yimin Cui (a6), Yong Huo (a5), Xiaobin Wang (a7), Hao Zhang (a1), Xianhui Qin (a2) (a3) and Xiping Xu (a1) (a2) (a3)...

Abstract

We aimed to evaluate the relationship of plasma Mg with the risk of new-onset hyperuricaemia and examine any possible effect modifiers in hypertensive patients. This is a post hoc analysis of the Uric acid (UA) Sub-study of the China Stroke Primary Prevention Trial (CSPPT). A total of 1685 participants were included in the present study. The main outcome was new-onset hyperuricaemia defined as a UA concentration ≥417 μmol/l in men or ≥357 μmol/l in women. The secondary outcome was a change in UA concentration defined as UA at the exit visit minus that at baseline. During a median follow-up duration of 4·3 years, new-onset hyperuricaemia occurred in 290 (17·2 %) participants. There was a significantly inverse relation of plasma Mg with the risk of new-onset hyperuricaemia (per sd increment; OR 0·85; 95 % CI 0·74, 0·99) and change in UA levels (per sd increment; β −3·96 μmol/l; 95 % CI −7·14, −0·79). Consistently, when plasma Mg was analysed as tertiles, a significantly lower risk of new-onset hyperuricaemia (OR 0·67; 95 % CI 0·48, 0·95) and less increase in UA levels (β −8·35 μmol/l; 95 % CI −16·12, −0·58) were found among participants in tertile 3 (≥885·5 μmol/l) compared with those in tertile 1 (<818·9 μmol/l). Similar trends were found in males and females. Higher plasma Mg levels were associated with a decreased risk of new-onset hyperuricaemia in hypertensive adults.

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Corresponding author

*Corresponding authors: Xiping Xu, fax +86-010-62736344, email xipingxu126@126.com; Xianhui Qin, fax +86-551-65161211, email pharmaqin@126.com; Hao Zhang, fax +86-010-62736344, email zhanghaocau@cau.edu.cn

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These authors contributed equally to the paper.

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References

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Plasma magnesium and the risk of new-onset hyperuricaemia in hypertensive patients

  • Jingjing Cao (a1) (a2), Jingping Zhang (a2), Yuanyuan Zhang (a3), Huan Li (a3), Chongfei Jiang (a3), Tengfei Lin (a1), Ziyi Zhou (a1), Yun Song (a1) (a2), Chengzhang Liu (a4), Lishun Liu (a1), Binyan Wang (a2), Jianping Li (a5), Yan Zhang (a5), Yimin Cui (a6), Yong Huo (a5), Xiaobin Wang (a7), Hao Zhang (a1), Xianhui Qin (a2) (a3) and Xiping Xu (a1) (a2) (a3)...

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