1.Victora, CG, Bahl, R, Barros, AJD, et al. (2016) Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet 387, 475–490.
2.Koletzko, B, Rodriguez-Palmero, M, Demmelmair, H, et al. (2001) Physiological aspects of human milk lipids. Early Hum Dev 65, S3–S18.
3.Schweiger, M, Eichmann, TO, Taschler, U, et al. (2014) Measurement of lipolysis. Methods Enzymol 538, 171–193.
4.Krohn, K, Demmelmair, H & Koletzko, B (2016) Macronutrient requirements for growth: fats and fatty acids. In Nutrition [Duggan, C, Watkins, J, Koletzkc, B and Walker, WA, editors]. Raleigh, NC: People’s Medical Publishing House.
5.Yang, J, Schmelzer, K, Georgi, K, et al. (2009) Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Chem 81, 8085–8093.
6.Alexandre-Gouabau, M-C, Moyon, T, Cariou, V, et al. (2018) Breast milk lipidome is associated with early growth trajectory in preterm infants. Nutrients 10, 164.
7.The Human Milk Banking Association of North America (2018) Guidelines for the Establishment and Operation of a Donor Human Milk Bank. Fort Worth, TX: Human Milk Banking Association of North America.
9.O’Connor, DL, Ewaschuk, JB & Unger, S (2015) Human milk pasteurization. Curr Opin Clin Nutr Metab Care 18, 269–275.
10.Peila, C, Emmerik, NE, Giribaldi, M, et al. (2017) Human milk processing: a systematic review of innovative techniques to ensure the safety and quality of donor milk. J Peditr Gastroenterol Nutr 64, 353–361.
11.Pitino, MA, Unger, S, Doyen, A, et al. (2019) High hydrostatic pressure processing better preserves the nutrient and bioactive compound composition of human donor milk. J Nutr 149, 497–504.
12.Delgado, FJ, Cava, R, Delgado, J, et al. (2014) Tocopherols, fatty acids and cytokines content of Holder pasteurised and high-pressure processed human milk. Dairy Sci Technol 94, 145–156.
13.Moltó-Puigmartí, C, Permanyer, M, Castellote, AI, et al. (2011) Effects of pasteurisation and high-pressure processing on vitamin C, tocopherols and fatty acids in mature human milk. Food Chem 124, 697–702.
14.Arnardottir, H, Orr, SK, Dalli, J, et al. (2016) Human milk proresolving mediators stimulate resolution of acute inflammation. Mucosal Immunol 9, 757–766.
15.Israel-Ballard, KA, Abrams, BF, Coutsoudis, A, et al. (2008) Vitamin content of breast milk from HIV-1-infected mothers before and after flash-heat treatment. J Acquir Immune Defic Syndr 48, 444–449.
16.Christen, L, Lai, CT, Hartmann, B, et al. (2013) Ultraviolet-C irradiation: a novel pasteurization method for donor human milk. PLOS ONE 8, e68120.
17.Folch, J, Lees, M & Sloane Stanley, GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497–509.
18.Chen, CT, Liu, Z & Bazinet, RP (2011) Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study. J Neurochem 116, 363–373.
19.Lin, LE, Chen, CT, Hildebrand, KD, et al. (2015) Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids. J Lipid Res 56, 390–402.
20.Colas, RA, Shinohara, M, Dalli, J, et al. (2014) Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. Am J Physiol Cell Physiol 307, C39–C54.
21.Henderson, TR, Fay, TN & Hamosh, M (1998) Effect of pasteurization on long chain polyunsaturated fatty acid levels and enzyme activities of human milk. J Pediatr 132, 876–878.
22.Alashmali, SM, Kitson, AP, Lin, L, et al. (2019) Maternal dietary n-6 polyunsaturated fatty acid deprivation does not exacerbate post-weaning reductions in arachidonic acid and its mediators in the mouse hippocampus. Nutr Neurosci 22, 223–234.
23.Galvan, P, Maggini, R, Lepri, L, et al. (2002) Effect of pasteurization and storage on some components of pooled human milk. J Chromatogr B Biomed Sci Appl 704, 1–10.
24.Yuhas, R, Pramuk, K & Lien, EL (2006) Human milk fatty acid composition from nine countries varies most in DHA. Lipids 41, 851–858.
25.Mozhaev, VV, Lange, R, Kudryashova, EV, et al. (1996) Application of high hydrostatic pressure for increasing activity and stability of enzymes. Biotechnol Bioeng 52, 320–331.
26.Capdevila, JH, Falck, JR & Harris, RC (2000) Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res 41, 163–181.
27.Galliard, T & Phillips, DR (1971) Lipoxygenase from potato tubers. Partial purification and properties of an enzyme that specifically oxygenates the 9-position of linoleic acid. Biochem J 124, 431–438.
28.Kumar, N, Gupta, G, Anilkumar, K, et al. (2016) 15-Lipoxygenase metabolites of α-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome. Sci Rep 6, 31649.
29.Wu, J, Gouveia-Figueira, S, Domellöf, M, et al. (2016) Oxylipins, endocannabinoids, and related compounds in human milk: levels and effects of storage conditions. Prostaglandins Other Lipid Mediat 122, 28–36.
30.Robinson, DT, Palac, HL, Baillif, V, et al. (2017) Long chain fatty acids and related pro-inflammatory, specialized pro-resolving lipid mediators and their intermediates in preterm human milk during the first month of lactation. Prostaglandins Leukot Essent Fatty Acids 121, 1–6.