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Natural evolution of weight status in Duchenne muscular dystrophy: a retrospective audit

  • Léonie Martigne (a1), Julia Salleron (a2), Michèle Mayer (a3), Jean-Marie Cuisset (a4), Alain Carpentier (a5), Véronique Neve (a6), Vincent Tiffreau (a7), Dominique Guimber (a1) and Frédéric Gottrand (a1)...

Abstract

The life expectancy of patients with Duchenne muscular dystrophy (DMD) has increased. A cross-sectional study of DMD patients showed that 54 % of 13-year-old patients are obese and that 54 % of 18-year-old patients are underweight. We aimed to describe the natural evolution of weight status in DMD. This retrospective multi-centre audit collected body-weight measurements for seventy DMD patients born before 1992. The body-weight:age ratio (W:A) was used to evaluate weight status in reference to the Griffiths and Edwards chart. At the age of 13 years, 73 % were obese and 4 % were underweight. At maximal follow-up (age 15–26 years, mean 18·3 (sd 2·3) years), 47 % were obese and 34 % were underweight. Obesity at the age of 13 years was associated with later obesity, whereas normal weight status and underweight in 13-year-old patients predicted later underweight. A W:A ≥ 151 % in 13-year-old patients predicted later obesity, and a W:A ≤ 126·5 % predicted later underweight. Our audit provides the first longitudinal information about the spontaneous outcome of weight status in DMD. Patients (13 years old) with a W:A ≥ 151 % were more likely to become obese in late adolescence, but obesity prevented later underweight. These data suggest that mild obesity in 13-year-old DMD patients (W:A between 120 and 150 %) should not be discouraged because it prevents later underweight.

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Corresponding author

*Corresponding author: L. Martigne, fax +33 3 20 44 61 34, email leonie.martigne@chru-lille.fr

References

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1 Davidson, ZE & Truby, H (2009) A review of nutrition in Duchenne muscular dystrophy. J Hum Nutr Diet 22, 383393.
2 McDonald, CM, Abresch, RT, Carter, GT, et al. (1995) Profiles of neuromuscular diseases. Duchenne muscular dystrophy. Am J Phys Med Rehabil 74, Suppl. 5, S70S92.
3 Willig, TN, Carlier, L, Legrand, M, et al. (1993) Nutritional assessment in Duchenne muscular dystrophy. Dev Med Child Neurol 35, 10741082.
4 Willig, TN, Bach, JR, Venance, V, et al. (1995) Nutritional rehabilitation in neuromuscular disorders. Semin Neurol 15, 1823.
5 Gottrand, F (1995) Nutritional aspects in Duchenne muscular dystrophy. Arch Pediatr 2, 481482.
6 Griffiths, RD & Edwards, RH (1988) A new chart for weight control in Duchenne muscular dystrophy. Arch Dis Child 63, 12561258.
7 Aldrich, TK (1993) Nutritional factors in the pathogenesis and therapy of respiratory insufficiency in neuromuscular diseases. Monaldi Arch Chest Dis 48, 327330.
8 Gershwin, ME, Borchers, AT & Keen, CL (2000) Phenotypic and functional considerations in the evaluation of immunity in nutritionally compromised hosts. J Infect Dis 182, Suppl. 1, S108S114.
9 Waterlow, JC (1973) Note on the assessment and classification of protein–energy malnutrition in children. Lancet 2, 8789.
10 Sachs, S (1982) Applied Statistics: A Handbook of Techniques, 2nd ed., pp. 333337. New York: Springer Verlag.
11 Verbeke, G & Molenberghs, G (2000) Mixed Models for Longitudinal Data. New York: Springer-Verlag.
12 Bushby, K, Bourke, R, Bullock, R, et al. (2005) The multidisciplinary management of Duchenne muscular dystrophy. Curr Paediatr 15, 292300.
13 Edwards, RH, Round, JM, Jackson, MJ, et al. (1984) Weight reduction in boys with muscular dystrophy. Dev Med Child Neurol 26, 384390.
14 Hankard, R, Gottrand, F, Turck, D, et al. (1996) Resting energy expenditure and energy substrate utilization in children with Duchenne muscular dystrophy. Pediatr Res 40, 2933.
15 Finder, JD, Birnkrant, D, Carl, J, et al. (2004) Respiratory care of the patient with Duchenne muscular dystrophy: ATS consensus statement. Am J Respir Crit Care Med 170, 456465.
16 Ramelli, GP, Aloysius, A, King, C, et al. (2007) Gastrostomy placement in paediatric patients with neuromuscular disorders: indications and outcome. Dev Med Child Neurol 49, 367371.
17 Seguy, D, Michaud, L, Guimber, D, et al. (2002) Efficacy and tolerance of gastrostomy feeding in pediatric forms of neuromuscular diseases. JPEN J Parenter Enteral Nutr 26, 298304.
18 Tilton, AH, Miller, MD & Khoshoo, V (1998) Nutrition and swallowing in pediatric neuromuscular patients. Semin Pediatr Neurol 5, 106115.
19 Galasko, CS, Delaney, C & Morris, P (1992) Spinal stabilisation in Duchenne muscular dystrophy. J Bone Joint Surg Br 74, 210214.

Keywords

Natural evolution of weight status in Duchenne muscular dystrophy: a retrospective audit

  • Léonie Martigne (a1), Julia Salleron (a2), Michèle Mayer (a3), Jean-Marie Cuisset (a4), Alain Carpentier (a5), Véronique Neve (a6), Vincent Tiffreau (a7), Dominique Guimber (a1) and Frédéric Gottrand (a1)...

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