Skip to main content Accessibility help
×
Home

The metabolism and biological activity of esterified vitamin D in the rat

  • D. R. Fraser (a1) and E. Kodicek (a1)

Abstract

1. [I-3H]Cholecalciferol and [I-3H]cholecalciferol palmitate in amounts equivalent to 2 μg cholecalciferol were injected into rachitic rats as aqueous preparations (intravenously) or in arachis oil (intramuscularly).

2. The radioactive faecal metabolites collected for up to 17 days were fractionated according to their polarity. The same pattern of excreted radioactivity was seen with intravenous and intramuscular cholecalciferol and intravenous cholecalciferol palmitate. Intramuscular chole-calciferol palmitate produced a higher proportion of the most polar metabolites in faeces.

3. Parenterally administered cholecalciferol palmitate in a rickets-healing biological assay had activity equivalent to unesterified cholecalciferol.

4. Vitamin D ester synthesized in vivo is considered to be eventually metabolized as vita- min D alcohol and to be available to vitamin D-requiring processes.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The metabolism and biological activity of esterified vitamin D in the rat
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      The metabolism and biological activity of esterified vitamin D in the rat
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      The metabolism and biological activity of esterified vitamin D in the rat
      Available formats
      ×

Copyright

References

Hide All
Bailey, B. E. (1943). J. Fish. Res. Bd Can. 6, 103.
Barnes, R. H., Fiala, G. & Kwong, E. (1963). Fedn Proc. Fedn Am. Socs exp. Biol. 22, 125.
Bots, J. P. L. (1957). Recl. Trav. chim. Pays-Bas Belge 76, 209.
Bourdillon, R. B., Bruce, H. M., Fischmann, C. & Webster, T. A. (1931). Spec. Rep. Ser. med. Res. Coun. no. 158.
Brown, R. A. & Sturtevant, M. (1949). Vitams Horn. 7, 189.
Fraser, D. R. & Kodicek, E. (1968 a). Biochem. J. 106, 485.
Fraser, D. R. & Kodicek, E. (1968 b). Biochem. J. 106, 491.
Fraser, D. R. & Kodicek, E. (1968 c). Biochem. J. 109, 457.
Kodicek, E. (1958). Proc. int. Congr. Biochem. IV. Vienna p. 198.
Norman, A. W., Lund, J. & DeLuca, H. F. (1964). Archs Biochem. Biophys. 108, 12.
Quaterman, J., Dalgarno, A. C. & Adam, A. (1964). Br. J. Nutr. 18, 79.
Wilson, P. W., Lawson, D. E. M. & Kodicek, E. (1967). Biochem. J. 103, 165.

The metabolism and biological activity of esterified vitamin D in the rat

  • D. R. Fraser (a1) and E. Kodicek (a1)

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed