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Low dose oral iodized oil for control of iodine deficiency in children

Published online by Cambridge University Press:  09 March 2007

Michael Zimmermann ,
Pierre Adou ,
Toni Torresani ,
Christophe Zeder  and
Richard Hurrell
Michael Zimmermann*
Affiliation:
Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zürich, Switzerland
Pierre Adou
Affiliation:
The National Institute of Public Health, Ministry of Health, Abidjan, Côte d'Ivoire
Toni Torresani
Affiliation:
The Department of Pediatrics, University of Zürich, Switzerland
Christophe Zeder
Affiliation:
Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zürich, Switzerland
Richard Hurrell
Affiliation:
Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zürich, Switzerland
*
*Corresponding author: Dr Michael Zimmermann, fax +41 1 704 5710, email michael.zimmermann@ilw.agrl.ethz.ch
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Abstract

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In areas where iodized salt is not available, oral iodized oil is often used to correct I deficiency despite a lack of consensus on the optimal dose or duration of effect, particularly in children, a main target group. Annual doses ranging from 400 to 1000 mg have been advocated for school-age children. Because lower doses of iodized oil have been shown to be effective in treating I deficiency in adults, the aim of this study was to evaluate the efficacy and safety of a low dose of oral iodized oil in goitrous I-deficient children. Goitrous children (n 104, mean age 8·4 years, range 6–12 years, 47 % female) received 0·4 ml oral iodized poppyseed-oil containing 200 mg I. Baseline measurements included I in spot urines (UI), serum thyroxine (T4), whole blood thyroid-stimulating hormone (TSH), and thyroid-gland volume using ultrasound. At 1, 5, 10, 15, 30 and 50 weeks post-intervention, UI, TSH and T4 were measured. At 10, 15, 30 and 50 weeks, thyroid-gland volume was remeasured. At 30 and 50 weeks the mean percentage change in thyroid volume from baseline was -35 % and -41 % respectively. The goitre rate fell to 38 % at 30 weeks and 17 % at 50 weeks. No child showed signs of I-induced hypo- or hyperthyroidism. UI remained significantly increased above baseline for the entire year (P < 0·001); the median UI at 50 weeks was 97 μg/l, at the World Health Organization cut-off value (100 μg/l) for I-deficiency disorders risk. In this group of goitrous children, an oral dose of 200 mg I as Lipiodol (Guerbert, Roissy CdG Cedex, France) was safe and effective for treating goitre and maintaining normal I status for at least 1 year.

Keywords

IodineGoitre
Type
short communication
Information
British Journal of Nutrition , Volume 84 , Issue 2 , August 2000 , pp. 139 - 141
Copyright
Copyright © The Nutrition Society 2000

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