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Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

  • Hamid Reza Talari (a1), Vahid Najafi (a1), Fariba Raygan (a2), Naghmeh Mirhosseini (a3), Vahidreza Ostadmohammadi (a4), Elaheh Amirani (a4), Mohsen Taghizadeh (a4), Mohammad Hajijafari (a5), Rana Shafabakhash (a4) and Zatollah Asemi (a4)...
  • Please note a correction has been issued for this article.

Abstract

This study was performed to evaluate the effects of vitamin D and n-3 fatty acids’ co-supplementation on markers of cardiometabolic risk in diabetic patients with CHD. This randomised, double-blinded, placebo-controlled trial was conducted among sixty-one vitamin D-deficient diabetic patients with CHD. At baseline, the range of serum 25-hydroxyvitamin D levels in study participants was 6·3–19·9 ng/ml. Subjects were randomly assigned into two groups either taking 50 000 IU vitamin D supplements every 2 weeks plus 2× 1000 mg/d n-3 fatty acids from flaxseed oil (n 30) or placebo (n 31) for 6 months. Vitamin D and n-3 fatty acids’ co-supplementation significantly reduced mean (P = 0·01) and maximum levels of left carotid intima–media thickness (CIMT) (P = 0·004), and mean (P = 0·02) and maximum levels of right CIMT (P = 0·003) compared with the placebo. In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β −0·40 mmol/l; 95 % CI −0·77, −0·03; P = 0·03), insulin (β −1·66 μIU/ml; 95 % CI −2·43, −0·89; P < 0·001), insulin resistance (β −0·49; 95 % CI −0·72, −0·25; P < 0·001) and LDL-cholesterol (β −0·21 mmol/l; 95 % CI −0·41, −0·01; P = 0·04), and a significant increase in insulin sensitivity (β +0·008; 95 % CI 0·004, 0·01; P = 0·001) and HDL-cholesterol (β +0·09 mmol/l; 95 % CI 0·01, 0·17; P = 0·02) compared with the placebo. Additionally, high-sensitivity C-reactive protein (β −1·56 mg/l; 95 % CI −2·65, −0·48; P = 0·005) was reduced in the supplemented group compared with the placebo group. Overall, vitamin D and n-3 fatty acids’ co-supplementation had beneficial effects on markers of cardiometabolic risk.

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Corresponding author

*Corresponding author: Z. Asemi, email asemi_r@yahoo.com

References

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Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

  • Hamid Reza Talari (a1), Vahid Najafi (a1), Fariba Raygan (a2), Naghmeh Mirhosseini (a3), Vahidreza Ostadmohammadi (a4), Elaheh Amirani (a4), Mohsen Taghizadeh (a4), Mohammad Hajijafari (a5), Rana Shafabakhash (a4) and Zatollah Asemi (a4)...
  • Please note a correction has been issued for this article.

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