Pluske, JR, Hampson, DJ & Williams, IH (1997) Factors influencing the structure and function of the small intestine in the weaned pig: a review. Livest Prod Sci 51, 215–236.
Lallès, J, Boudry, G, Favier, C, et al. (2004) Gut function and dysfunction in young pigs: physiology. Anim Res 53, 301–316.
Pluske, JR (2013) Feed- and feed additives-related aspects of gut health and development in weanling pigs. J Anim Sci Biotechnol 4, 1.
Moeser, AJ, Pohl, CS & Rajput, M (2017) Weaning stress and gastrointestinal barrier development: implications for lifelong gut health in pigs. Anim Nutr 3, 313–321.
Pluske, JR, Turpin, DL & Kim, JC (2018) Gastrointestinal tract (gut) health in the young pig. Anim Nutr 4, 187–196.
O’Doherty, JV, Bouwhuis, MA & Sweeney, T (2017) Novel marine polysaccharides and maternal nutrition to stimulate gut health and performance in post-weaned pigs. Anim Prod Sci 57, 2376–2385.
Kim, JC, Hansen, CF, Mullan, BP, et al. (2012) Nutrition and pathology of weaner pigs: nutritional strategies to support barrier function in the gastrointestinal tract. Anim Feed Sci Technol 173, 3–16.
Long, L, Chen, J, Zhang, Y, et al. (2017) Correction: comparison of porous and nano zinc oxide for replacing high-dose dietary regular zinc oxide in weaning piglets. PLOS ONE 12, e0188587.
Deville, C, Gharbi, M, Dandrifosse, G, et al. (2007) Study on the effects of laminarin, a polysaccharide from seaweed, on gut characteristics. J Sci Food Agric 87, 1717–1725.
Rioux, LE, Turgeon, SL & Beaulieu, M (2010) Structural characterization of laminaran and galactofucan extracted from the brown seaweed Saccharina longicruris
. Phytochemistry 71, 1586–1595.
Walsh, AM, Sweeney, T, O’Shea, CJ, et al. (2013) Effect of dietary laminarin and fucoidan on selected microbiota, intestinal morphology and immune status of the newly weaned pig. Br J Nutr 110, 1630–1638.
Garcia-Vaquero, M, Rajauria, G, O’Doherty, JV, et al. (2017) Polysaccharides from macroalgae: recent advances, innovative technologies and challenges in extraction and purification. Food Res Int 99, 1011–1020.
Smith, AG, O’Doherty, JV, Reilly, P, et al. (2011) The effects of laminarin derived from Laminaria digitata on measurements of gut health: selected bacterial populations, intestinal fermentation, mucin gene expression and cytokine gene expression in the pig. Br J Nutr 105, 669–677.
National Research Council (2012) Nutrient Requirements of Swine, 11th ed. Washington, DC: National Academies Press.
Walsh, AM, Sweeney, T, O’Shea, CJ, et al. (2013) Effect of supplementing varying inclusion levels of laminarin and fucoidan on growth performance, digestibility of diet components, selected faecal microbial populations and volatile fatty acid concentrations in weaned pigs. Anim Feed Sci Tech 183, 151–159.
Geiss, GK, Bumgarner, RE, Birditt, B, et al. (2008) Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol 26, 317–325.
Vigors, S, JV, OD, Ryan, M, et al. (2019) Analysis of the basal colonic innate immune response of pigs divergent in feed efficiency and following an ex vivo lipopolysaccharide challenge. Physiol Genomics 51, 443–448.
O’Shea, CJ, Sweeney, T, Bahar, B, et al. (2012) Indices of gastrointestinal fermentation and manure emissions of growing-finishing pigs as influenced through singular or combined consumption of Lactobacillus plantarum and inulin. J Anim Sci 90, 3848–3857.
Pierce, KM, Sweeney, T, Callan, JJ, et al. (2006) The effect of inclusion of a high lactose supplement in finishing diets on nutrient digestibility, nitrogen excretion, volatile fatty acid concentrations and ammonia emission from boars. Anim Feed Sci Tech 125, 45–60.
Van Soest, PVR, Robertson, JB & Lewis, BA (1991) Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. J Dairy Sci 74, 3583–3597.
Heim, G, Walsh, AM, Sweeney, T, et al. (2014) Effect of seaweed-derived laminarin and fucoidan and zinc oxide on gut morphology, nutrient transporters, nutrient digestibility, growth performance and selected microbial populations in weaned pigs. Br J Nutr 111, 1577–1585.
Jayaraman, B & Nyachoti, CM (2017) Husbandry practices and gut health outcomes in weaned piglets: a review. Anim Nutr 3, 205–211.
Drozdowski, L & Thomson, AB (2006) Intestinal mucosal adaptation. World J Gastroenterol 12, 4614–4627.
Wang, Y, Chandra, R, Samsa, LA, et al. (2011) Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor. Am J Physiol Gastrointest Liver Physiol 300, G528–G537.
Prinz, P & Stengel, A (2017) Control of food intake by gastrointestinal peptides: mechanisms of action and possible modulation in the treatment of obesity. J Neurogastroenterol Motil 23, 180–196.
Dou, S, Gadonna-Widehem, P, Rome, V, et al. (2017) Characterisation of early-life fecal microbiota in susceptible and healthy pigs to post-weaning diarrhoea. PLOS ONE 12, e0169851.
Guevarra, RB, Lee, JH, Lee, SH, et al. (2019) Piglet gut microbial shifts early in life: causes and effects. J Anim Sci Biotechnol 10, 1.
Gresse, R, Chaucheyras-Durand, F, Fleury, MA, et al. (2017) Gut microbiota dysbiosis in postweaning piglets: understanding the keys to health. Trends Microbiol 25, 851–873.
Rhouma, M, Fairbrother, JM, Beaudry, F, et al. (2017) Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies. Acta Vet Scand 59, 31.
Sweeney, T & O’Doherty, JV (2016) Marine macroalgal extracts to maintain gut homeostasis in the weaning piglet. Domest Anim Endocrin 56, S84–S89.
Valeriano, VDV, Balolong, MP & Kang, D-K (2017) Probiotic roles of Lactobacillus sp. in swine: insights from gut microbiota. J Appl Microbiol 122, 554–567.
Bedford, A & Gong, J (2018) Implications of butyrate and its derivatives for gut health and animal production. Anim Nutr 4, 151–159.
Liu, YL (2015) Fatty acids, inflammation and intestinal health in pigs. J Anim Sci Biotechnol 6, 41
Williams, BA, Verstegen, MWA & Tamminga, S (2001) Fermentation in the large intestine of single-stomached animals and its relationship to animal health. Nutr Res Rev 14, 207–227.
Xiong, X, Tan, B, Song, M, et al. (2019) Nutritional intervention for the intestinal development and health of weaned pigs. Front Vet Sci 6, 46.
Cuff, MA, Lambert, DW & Shirazi-Beechey, SP (2002) Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J Physiol 539, 361–371.
Liu, T, Zhang, L, Joo, D, et al. (2017) NF-kappaB signaling in inflammation. Signal Transduct Target Ther 2, 17023
Xiao, K, Song, ZH, Jiao, LF, et al. (2014) Developmental changes of TGF-β1 and Smads signaling pathway in intestinal adaption of weaned pigs. PLOS ONE 9, e104589
Pearce, SC, Mani, V, Weber, TE, et al. (2013) Heat stress and reduced plane of nutrition decreases intestinal integrity and function in pigs. J Anim Sci 91, 5183–5193.
Tao, X, Xu, Z & Wan, J (2015) Intestinal microbiota diversity and expression of pattern recognition receptors in newly weaned piglets. Anaerobe 32, 51–56.
Kim, YS & Ho, SB (2010) Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep 12, 319–330.
Sauvant, D, Perez, JM & Tran, G (2004) Table of Composition and Nutritional Value of Feed Materials. Pigs, Poultry, Cattle, Sheep, Goats, Rabbits, Horses, Fish. Wageningen, The Netherlands: Wageningen Academic Publishers.