1Hertog, MG, Feskens, EJ, Hollman, PC, et al. (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342, 1007–1011.
2Sampson, L, Rimm, E, Hollman, PC, et al. (2002) Flavonol and flavone intakes in US health professionals. J Am Diet Assoc 102, 1414–1420.
3Manach, C, Scalbert, A, Morand, C, et al. (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79, 727–747.
4Perez-Vizcaino, F, Bishop-Bailley, D, Lodi, F, et al. (2006) The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells. Biochem Biophys Res Commun 346, 919–925.
5Perez-Vizcaino, F, Duarte, J & Andriantsitohaina, R (2006) Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radic Res 40, 1054–1065.
6Perez-Vizcaino, F, Duarte, J, Jimenez, R, et al. (2009) Antihypertensive effects of the flavonoid quercetin. Pharmacol Rep 61, 67–75.
7Loke, WM, Proudfoot, JM, Hodgson, JM, et al. (2010) Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. Arterioscler Thromb Vasc Biol 30, 749–757.
8Duarte, J, Perez Vizcaino, F, Utrilla, P, et al. (1993) Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure–activity relationships. Gen Pharmacol 24, 857–862.
9Ibarra, M, Perez-Vizcaino, F, Cogolludo, A, et al. (2002) Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria. Planta Med 68, 307–310.
10Duarte, J, Perez-Palencia, R, Vargas, F, et al. (2001) Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol 133, 117–124.
11Ihm, SH, Lee, JO, Kim, SJ, et al. (2009) Catechin prevents endothelial dysfunction in the prediabetic stage of OLETF rats by reducing vascular NADPH oxidase activity and expression. Atherosclerosis 206, 47–53.
12Pignatelli, P, Pulcinelli, FM, Celestini, A, et al. (2000) The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide. Am J Clin Nutr 72, 1150–1155.
13Pignatelli, P, Di Santo, S, Buchetti, B, et al. (2006) Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation: effect on platelet recruitment. FASEB J 20, 1082–1089.
14Silberberg, M, Morand, C, Manach, C, et al. (2005) Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism. Life Sci 77, 3156–3167.
15Lopez-Lopez, G, Moreno, L, Cogolludo, A, et al. (2004) Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle. Mol Pharmacol 65, 851–859.
16Jimenez, R, Andriambeloson, E, Duarte, J, et al. (1999) Involvement of thromboxane A2 in the endothelium-dependent contractions induced by myricetin in rat isolated aorta. Br J Pharmacol 127, 1539–1544.
17Cogolludo, A, Moreno, L, Frazziano, G, et al. (2009) Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction. Cardiovasc Res 82, 296–302.
18Lodi, F, Jimenez, R, Moreno, L, et al. (2008) Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta. Atherosclerosis 204, 34–39.
19Perez-Vizcaino, F, Cogolludo, AL, Zaragoza-Arnaez, F, et al. (1999) Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta. Br J Pharmacol 128, 1419–1426.
20Tallarida, RJ (2001) Drug synergism: its detection and applications. J Pharmacol Exp Ther 298, 865–872.
21Perez-Vizcaino, F, Ibarra, M, Cogolludo, AL, et al. (2002) Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. J Pharmacol Exp Ther 302, 66–72.
22Lam, CS, Borlaug, BA, Kane, GC, et al. (2009) Age-associated increases in pulmonary artery systolic pressure in the general population. Circulation 119, 2663–2670.
23Sanchez, M, Lodi, F, Vera, R, et al. (2007) Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta. J Nutr 137, 910–915.
24Sanchez, M, Galisteo, M, Vera, R, et al. (2006) Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 24, 75–84.
25Halliwell, B (2008) Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch Biochem Biophys 476, 107–112.
26Cogolludo, A, Frazziano, G, Briones, AM, et al. (2007) The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2. Role in vasodilatation. Cardiovasc Res 73, 424–431.
27Cirico, TL & Omaye, ST (2006) Additive or synergetic effects of phenolic compounds on human low density lipoprotein oxidation. Food Chem Toxicol 44, 510–516.
28Manach, C, Williamson, G, Morand, C, et al. (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81, 230S–242S.
29Lodi, F, Jimenez, R, Moreno, L, et al. (2008) Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta. Atherosclerosis 204, 34–39.
30Bieger, J, Cermak, R, Blank, R, et al. (2008) Tissue distribution of quercetin in pigs after long-term dietary supplementation. J Nutr 138, 1417–1420.