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Intake of n-3 fatty acids and long-term outcome in renal transplant recipients: a post hoc analysis of a prospective cohort study

  • Ilse G. Pranger (a1), Eke G. Gruppen (a1), Else van den Berg (a1), Sabita S. Soedamah-Muthu (a2), Gerjan Navis (a1), Rijk O. B. Gans (a1), Frits A. J. Muskiet (a3), Ido P. Kema (a3), Michel M. Joosten (a1) and Stephan J. L. Bakker (a1)...

Abstract

Supplementation with n-3 fatty acids may improve long-term outcomes of renal transplant recipients (RTR). Recent evidence suggests that EPA and DHA have different outcomes compared with α-linolenic acid (ALA). We examined the prospective associations of EPA–DHA and ALA intakes with graft failure and all-cause mortality in 637 RTR. During 3·1 years (interquartile range 2·7, 3·8) of follow-up, forty-one developed graft failure and sixty-seven died. In age- and sex-adjusted analyses, EPA–DHA and ALA intakes were not associated with graft failure. EPA–DHA intake was not significantly associated with mortality (hazard ratio (HR) 0·79; 95% CI 0·54, 1·15 per 0·1 energy% difference). ALA intake was significantly associated with mortality (HR 1·17; 95% CI 1·04, 1·31 per 0·1 energy% difference). This association remained following adjustments for BMI, proteinuria and intakes of fat, carbohydrate and protein. RTR in the highest tertile of ALA intake exhibited about 2-fold higher mortality risk (HR 2·21; 95% CI 1·23, 3·97) compared with the lowest tertile. In conclusion, ALA intake may be associated with increased mortality in RTR. Future RCT are needed to confirm these results.

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Corresponding author

* Corresponding author: I. G. Pranger, email I.g.Pranger@umcg.nl

References

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Intake of n-3 fatty acids and long-term outcome in renal transplant recipients: a post hoc analysis of a prospective cohort study

  • Ilse G. Pranger (a1), Eke G. Gruppen (a1), Else van den Berg (a1), Sabita S. Soedamah-Muthu (a2), Gerjan Navis (a1), Rijk O. B. Gans (a1), Frits A. J. Muskiet (a3), Ido P. Kema (a3), Michel M. Joosten (a1) and Stephan J. L. Bakker (a1)...

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