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The influence of riboflavin deficiency on absorption and liver storage of iron in the growing rat

Published online by Cambridge University Press:  09 March 2007

Delana A. Adelekan  and
David I. Thurnham
Delana A. Adelekan
Affiliation:
Department of Human Nutrition, London School of Hygiene and Tropical Medicine, Keppel Street, London WClE 7HT
David I. Thurnham
Affiliation:
Department of Human Nutrition, London School of Hygiene and Tropical Medicine, Keppel Street, London WClE 7HT
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Abstract

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1. Iron absorption was measured in weanling riboflavin-deficient (RD) rats or weight-matched (WM) controls fed on appropriate diets for 7 weeks. Concentrations of radio-Fe (68Fe) in plasma were monitored every 30 min for 4 h following intragastric administration.

2. Total Fe absorption in RD rats was significantly lower than that in WM controls, and the tissues of the stomach and small intestine of RD rats retained significantly (P < 0.001) more 68Fe by comparison with WM groups.

3. In a separate experiment, ferritin-Fe concentrations were measured in the livers of four groups of rats (adlib. (C), pair-fed (PF) and WM controls and RD) at day 0, and subsequently at days 14, 21, 28, 35 and 49.

4. Liver ferritin-Fe concentration was significantly lower (P < 0.05) in RD rats than in all other controls after 3 weeks on the respective diets and remained lower for the remainder of the experiment.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 56 , Issue 1 , July 1986 , pp. 171 - 179
Copyright
Copyright © The Nutrition Society 1986

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