Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-25T01:17:12.669Z Has data issue: false hasContentIssue false

Immunomodulatory properties of milk

Published online by Cambridge University Press:  09 March 2007

Martin L. Cross
Affiliation:
Milk and Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerston North, New Zealand
H. S. Gill*
Affiliation:
Milk and Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerston North, New Zealand
*
*Corresponding author: Professor H. S. Gill, fax +64 6 350 5446, email H.S.Gill@massey.ac.nz
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

There is increasing commercial interest in the production of functional foodstuffs which have health-promoting properties. Over the last five to ten years, significant progress has been made in the identification and characterisation of bovine milk components that can affect the function of the immune system. This review outlines the major components of bovine milk that have been shown to modulate immune function, and discusses experimental approaches to the identification of various facets of the immune response that are known to be affected by milk-derived proteins.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2000

References

Barta, O, Barta, VD, Crisman, MV & Akers, RM (1991) Inhibition of lymphocyte blastogenesis by whey American Journal of Veterinary Research 52, 247253.CrossRefGoogle ScholarPubMed
Bounous, G, Baruchel, S, Falutz, J & Gold, P (1993) Whey proteins as a food supplement in HIV-seropositive individuals Clinical and Investigative Medicine 16, 204209.Google ScholarPubMed
Bounous, G, Batist, G & Gold, P (1989) Immunoenhancing property of dietary whey protein in mice: role of glutathione Clinical and Investigative Medicine 12, 154161.Google ScholarPubMed
Bounous, G & Kongshavn, PAL (1982) Influence of dietary proteins on the immune system of mice Journal of Nutrition 112, 17471755.CrossRefGoogle ScholarPubMed
Bounous, G & Kongshavn, PAL (1985) Differential effect of dietary protein type on the B-cell and T-cell immune responses in mice Journal of Nutrition 115, 14031408.CrossRefGoogle ScholarPubMed
Bounous, G, Kongshavn, PAL & Gold, P (1988) The immunoenhancing property of dietary whey protein concentrate Clinical and Investigative Medicine 11, 271278.Google ScholarPubMed
Bounous, G, Letourneau, L & Kongshavn, PAL (1983) Influence of dietary protein type on the immune system of mice Journal of Nutrition 113, 14151421.CrossRefGoogle ScholarPubMed
Bounous, G, Shenouda, N, Kongshavn, PAL & Osmond, DG (1985) Mechanism of altered B cell response induced by changes in dietary protein type in mice Journal of Nutrition 115, 14091417.CrossRefGoogle ScholarPubMed
Bounous, G, Stevenson, MM & Kongshavn, PAL (1981) Influence of dietary alpha-lactalbumin hydrolysate on the immune system of mice and resistance to salmonellosis Journal of Infectious Diseases 144, 281.CrossRefGoogle ScholarPubMed
Carr, RI, Webster, D, Sadi, D, Williams, H & Walsh, N (1990) Immunomodulation by opioids from dietary casein Annals of the New York Academy of Sciences 574, 374376.CrossRefGoogle Scholar
Cooray, R (1996) Casein effects on the myeloperoxidase-mediated oxygen-dependent bactericidal activity of bovine neutrophils Veterinary Immunology and Immunopathology 51, 5565.CrossRefGoogle ScholarPubMed
Cross, ML & Gill, HS (1999) Modulation of immune function by a modified bovine whey protein concentrate Immunology and Cell Biology 77, 345350.CrossRefGoogle ScholarPubMed
Debabbi, H, Dubarry, M, Ranteau, M & Tome, D (1998) Bovine lactoferrin induces both mucosal and systemic immune responses in mice Journal of Dairy Research 65, 283293.CrossRefGoogle Scholar
Gill, HS & Rutherfurd, KJ (1998) Immunomodulatory properties of bovine milk Bulletin of the International Dairy Federation 336, 3135.Google Scholar
Gill, HS, Rutherfurd, KJ, Cross, ML (2000) Bovine milk: A unique source of immumodulatory ingredients for functional foods. In Functional Foods II – Claims and Evidence, pp. 8290 [Buttriss, J and Saltmarsh, M, editors]. Cambridge: Royal Society of Chemistry Press.Google Scholar
Goddeeris, BML & Morrison, WI (1994) Cell Mediated Immunity in Ruminants.Google Scholar
Korhonen, H, Pihlanto-Leppala, A, Rantamaki, P & Tupasela, T (1998) The functional and biological properties of whey proteins: prospects for the development of functional foods Agricultural and Food Science in Finland 7, 283296.CrossRefGoogle Scholar
Kulczycki, A & MacDermott, RP (1985) Bovine IgG and human immune responses, Con A-induced mitogenesis of human mononuclear cells is suppressed by bovine IgG International Archives of Allergy and Applied Immunology 77, 255258.CrossRefGoogle ScholarPubMed
Kulczycki, A, Nash, GS, Bertovich, MJ, Burack, HD & MacDermott, RP (1987) Bovine milk IgG, but not serum IgG, inhibits pokeweed mitogen-induced antibody secretion by human peripheral blood mononuclear cells Journal of Clinical Immunology 7, 3745.CrossRefGoogle Scholar
Kulkarni, AB & Karlsson, S (1993) Transforming growth factor b1-knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease American Journal of Pathology 143, 39.Google Scholar
Mattsby-Baltzer, I, Roseanu, A, Motas, C, Elverfors, J, Engberg, I & Hanson, LA (1996) Lactoferrin or a fragment thereof inhibits the endotoxin-induced interleukin-6 response in human monocytic cells Pediatric Research 40, 257262.CrossRefGoogle ScholarPubMed
Metcalf, JA, Gallin, JI, Nauseef, WM & Root, RK (1986) Laboratory Manual of Neutrophil Function.Google Scholar
Miyauchi, H, Hashimoto, S, Nakajima, M, Shinoda, I, Fukuwatari, Y & Hayasawa, H (1998) Bovine lactoferrin stimulates the phagocytic activity of human neutrophils: identification of its active domain Cellular Immunology 187, 3437.CrossRefGoogle ScholarPubMed
Monnai, M, Horimoto, Y & Otani, H (1998) Immunomodificatory effect of dietary bovine kappa-caseinoglycopeptide on serum antibody levels and proliferative responses of lymphocytes in mice Milchwissenshaft 53, 129132.Google Scholar
Monnai, M & Otani, H (1997) Effect of bovine kappa-caseinoglycopeptide on secretion of interleukin-1 family cytokines by P388D1 cells, a line derived from mouse monocyte/macrophage Milchwissenshaft 52, 192196.Google Scholar
Newby, TJ, Stokes, CR & Bourne, FJ (1982) Immunological activity of milk Veterinary Immunology and Immunopathology 3, 6794.CrossRefGoogle Scholar
Otani, H & Futakami, M (1994) Effects of bovine milk proteins on the phagocytic property and formation of nitrite by mouse peritoneal macrophages Animal Science and Technology 65, 423431.Google Scholar
Otani, H & Futakami, M (1996) Modification of nitrite production and phagocytosis of thioglycollate-elicited mouse peritoneal macrophages by bovine casein digests Food and Agricultural Immunology 8, 5969.CrossRefGoogle Scholar
Otani, H & Hata, I (1995) Inhibition of proliferative responses of mouse spleen lymphocytes and rabbit Peyer's patch cells by bovine milk caseins and their digests Journal of Dairy Research 62, 339348.CrossRefGoogle ScholarPubMed
Otani, H, Horimoto, Y & Monnai, M (1996) Suppression of interleukin-2 receptor expression on mouse CD4+ T cells by bovine kappa-caseinoglycopeptide Bioscience, Biotechnology and Biochemistry 60, 10171019.CrossRefGoogle ScholarPubMed
Otani, H & Monnai, M (1993) Inhibition of proliferative responses of mouse spleen lymphocytes by bovine milk kappa-casein digests Food and Agricultural Immunology 5, 219229.CrossRefGoogle Scholar
Otani, H & Monnai, M (1995) Induction of an interleukin-1 receptor antagonist-like component produced from mouse spleen cells by bovine kappa-caseinoglycopeptide Bioscience, Biotechnology and Biochemistry 59, 11661168.CrossRefGoogle ScholarPubMed
Otani, H, Monnai, M & Hosono, A (1992) Bovine kappa-casein as inhibitor of the proliferation of mouse splenocytes induced by lipopolysaccharide stimulation Milchwissenschaft 47, 512515.Google Scholar
Otani, H, Monnai, M, Kawasaki, Y, Kawakami, H & Tanimoto, M (1995) Inhibition of mitogen-induced proliferative responses of lymphocytes by bovine kappa-caseinoglycopeptides having different carbohydrate chains Journal of Dairy Research 62, 349357.CrossRefGoogle ScholarPubMed
Otani, H & Odashima, M (1997) Inhibition of proliferative responses of mouse spleen lymphocytes by lacto- and ovotransferrins Food and Agricultural Immunology 9, 193201.CrossRefGoogle Scholar
Otani, H & Yamada, Y (1994) Characterization of bovine colostral proteins with inhibitory activity in passive cutaneous anaphylaxis Milchwissenschaft 49, 2024.Google Scholar
Otani, H & Yamada, Y (1995) Effects of bovine kappa-casein and lactoferrins on several experimental models of allergic disease Milchwissenschaft 50, 549553.Google Scholar
Politis, I, Zhao, X, McBride, BW & Burton, JH (1991) Effect of bovine skim milk and whey on monocyte function Journal of Dairy Science 74, 24672471.CrossRefGoogle ScholarPubMed
Rejman, JJ, Lewis, MJ & Oliver, SP (1993) Enhancement of mammary gland mononuclear cell proliferation by interleukin-2 in the presence of lactoferrin Food and Agricultural Immunology 5, 5156.CrossRefGoogle Scholar
Rejman, JJ & Oliver, SP (1992) Bimodal effects of lactoferrin on proliferation of an interleukin-2 dependent bovine cytotoxic T lymphocyte cell line Journal of Dairy Science 75, (Suppl. 1), 302.Google Scholar
Rejman, JJ, Oliver, SP & Turner, JD (1992) Proliferation of the MAC-T bovine epithelial cell line in the presence of lactoferrin and transferrin Journal of Dairy Science 75, (Suppl. 1), 226.Google Scholar
Rejman, JJ, Payne, KD, Lewis, MJ, Torre, PM, Muenchen, RA & Oliver, SP (1992) Influence of apo- and iron-saturated lactoferrin and transferrin, immunoglobulin G and serum albumin on proliferation of bovine peripheral blood mononuclear cells Food and Agricultural Immunology 4, 253257.CrossRefGoogle Scholar
Roitt, I (1997) Essential Immunology.Google Scholar
Shimizu, K, Matsuzawa, H, Okada, K, Tazume, S, Dosako, S, Kawasaki, Y, Hashimoto, K & Koga, Y (1996) Lactoferrin-mediated protection of the host from murine cytomegalovirus infection by a T cell-dependent augmentation of natural killer cell activity Archives of Virology 141, 18751889.CrossRefGoogle Scholar
Shinoda, I, Takase, M, Fukuwatari, Y, Shimamura, S, Koller, M & Konig, W (1996) Effects of lactoferrin and lactoferricin on the release of interleukin 8 from human polymorphonuclear leukocytes Bioscience, Biotechnology and Biochemistry 60, 521523.CrossRefGoogle ScholarPubMed
Stelwagen, K, Politis, I, Guo, MR, Kindstedt, PS, Davis, SR & Farr, VC (1994) Mammary derived growth inhibitor in bovine milk, effect of milking frequency and somatotropin administration Canadian Journal of Animal Science 74, 695698.CrossRefGoogle Scholar
Stoeck, M, Ruegg, C, Miescher, S, Carrel, S, Cox, D, Fliedner, V, Alkan, S, Von-Fliedner, V (1989) Comparison of the immunosuppressive properties of milk growth factor and transforming growth factors beta1 and beta2 Journal of Immunology 143, 32583265.CrossRefGoogle Scholar
Torre, PM & Oliver, SP (1989) Suppression of mitogenic response of peripheral blood mononuclear cells by bovine mammary secretions Journal of Dairy Science 72, 219227.CrossRefGoogle ScholarPubMed
Watson, DL, Francis, GL & Ballard, FJ (1992) Factors in ruminant colostrum that influence cell growth and murine IgE antibody responses Journal of Dairy Research 59, 369380.CrossRefGoogle ScholarPubMed
Wong, CW, Liu, AH, Regester, GO, Francis, GL & Watson, DL (1997) Influence of whey and purified whey proteins on neutrophil functions in sheep Journal of Dairy Research 64, 281288.CrossRefGoogle ScholarPubMed
Wong, CW, Seow, HF, Husband, AJ, Regester, GO & Watson, DL (1997) Effects of purified bovine whey factors on cellular immune functions in ruminants Veterinary Immunology and Immunopathology 56, 8596.CrossRefGoogle ScholarPubMed
Wong, CW, Seow, HF, Liu, AH, Husband, AJ, Smithers, GW & Watson, DL (1996) Modulation of immune responses by bovine beta-casein Immunology and Cell Biology 74, 323329.CrossRefGoogle ScholarPubMed
Wong, CW & Watson, DL (1995) Immunomodulatory effects of dietary whey proteins in mice Journal of Dairy Research 62, 359368.CrossRefGoogle ScholarPubMed
Yamada, K, Matsumara, K, Suzaki, M, Shirahata, S & Murakami, H (1991) Stimulation and inhibition of interferon-β production of human diploid fibroblasts by foodstuffs Agricultural Biology and Chemistry 55, 829832.Google ScholarPubMed
Yun, SS, Sugita-Konishi, Y, Kumagai, S & Yamauchi, K (1996) Isolation of mitogenic glycophosphopeptides from cheese whey protein concentrate BioScience, Biotechnology and Biochemistry 60, 429433.Google ScholarPubMed
Zavizion, B, Politis, I, Gorewit, RC, Turner, JD, Spitzer, E & Grosse, R (1993) Effect of mammary-derived growth inhibitor on proliferation of MAC-T bovine mammary epithelial cells Journal of Dairy Science 76, 37213726.CrossRefGoogle ScholarPubMed