1Ceballos-Picot, I, Nicole, A, Clement, M, et al. (1992) Age-related changes in antioxidant enzymes and lipid peroxidation in brains of control and transgenic mice overexpressing copper-zinc superoxide dismutase. Mutat Res 275, 281–293.
2Aw, TY (1999) Molecular and cellular responses to oxidative stress and changes in oxidation-reduction imbalance in the intestine. Am J Clin Nutr 70, 557–565.
3Cnubben, NHP, Rietjens, IMCM, Wortelboer, H, et al. (2001) The interplay of glutathione-related processes in antioxidant defense. Environ Toxicol Pharmacol 10, 141–152.
4Brigelius, R (1985) . In Oxidative Stress, pp. 243–272 [Sies, H, editor]. New York: Academic Press.
5Salvi, M, Battaglia, V, Brunati, AM, et al. (2007) Catalase takes part in rat liver mitochondria oxidative stress defense. J Biol Chem 282, 24407–24415.
6Mates, JM & Sanchez-Jimenez, FM (2000) Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int J Biochem Cell Biol 32, 157–170.
7Mather, M & Rottenberg, H (2000) Aging enhances the activation of the permeability transition pore in mitochondria. Biochem Biophys Res Commun 273, 603–608.
8Zoratti, M & Szabo, I (1995) The mitochondrial permeability transition. Biochim Biophys Acta 1241, 139–176.
9Donaldson, MS (2004) Nutrition and cancer: a review of the evidence for an anti-cancer diet. Nutr J 3, 19.
10Arii, M, Miki, M, Hosoyama, R, et al. (1998) Chemopreventive effect of grape seed extract on intestinal carcinogenesis in the APCM in mouse. Proc Am Assoc Cancer Res 39, 20.
11Seeram, NP, Adams, LS, Henning, SM, et al. (2005) In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem 16, 360–367.
12Sanchez-Moreno, C, Larrauri, JA & Saura-Calixto, F (1999) Free radical scavenging capacity and inhibition of lipid oxidation of wines, grape juices and related polyphenolic constituents. Food Res Int 32, 407–412.
13Garbisa, S, Sartor, L, Biggin, S, et al. (2001) Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate. Cancer 91, 822–832.
14Russo, A, Acquaviva, R, Campisi, A, et al. (2000) Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. Cell Biol Toxicol 16, 91–98.
15Young, JF, Dragsted, LO, Daneshvar, B, et al. (2000) The effect of grape-skin extract on oxidative status. Br J Nutr 84, 505–513.
16Bobek, P (1999) Dietary tomato and grape pomace in rats: effect on lipids in serum and liver, and on antioxidant status. Br J Biomed Sci 56, 109–113.
17Dani, C, Oliboni, LS, Pasquali, MA, et al. (2008) Intake of purple grape juice as a hepatoprotective agent in Wistar rats. J Med Food 11, 127–132.
18Roig, R, Cascon, E, Arola, L, et al. (2002) Procyanidins protect Fao cells against hydrogen peroxide-induced oxidative stress. Biochim Biophys Acta 1572, 25–30.
19Puiggros, F, Llopiz, N, Ardevol, A, et al. (2005) Grape seed procyanidins prevent oxidative injury by modulating the expression of antioxidant enzyme systems. J Agric Food Chem 53, 6080–6086.
20Myhrstad, MC, Carlsen, H, Nordstrom, O, et al. (2002) Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med 32, 386–393.
21Abrahamse, SL, Pool-Zobel, BL & Rechkemmer, G (1999) Potential of short chain fatty acids to modulate the induction of DNA damage and changes in the intracellular calcium concentration by oxidative stress in isolated rat distal colon cells. Carcinogenesis 20, 629–634.
22Rosignoli, P, Fabiani, R, De Bartolomeo, A, et al. (2008) Genotoxic effect of bile acids on human normal and tumour colon cells and protection by dietary antioxidants and butyrate. Eur J Nutr 47, 301–309.
23Giovannini, C, Matarrese, P, Scazzocchio, B, et al. (2002) Mitochondria hyperpolarization is an early event in oxidized low-density lipoprotein-induced apoptosis in Caco-2 intestinal cells. FEBS Lett 523, 200–206.
24Nakayama, T, Niimi, T, Osawa, T, et al. (1992) The protective role of polyphenols in cytotoxicity of hydrogen peroxide. Mutat Res 281, 77–80.
25Saura-Calixto, F (1998) Antioxidant dietary fiber product: a new concept and a potential food ingredient. J Agric Food Chem 46, 4303–4306.
26Goñi, I & Serrano, J (2005) The intake of dietary fiber from grape seeds modifies the antioxidant status in rat cecum. J Sci Food Agric 85, 1877–1881.
27Martín-Carrón, N, Saura-Calixto, F & Goñi, I (2000) Effects of dietary fibre- and polyphenol-rich grape products on lipidaemia and nutritional parameters in rats. J Agric Food Chem 80.
28Pérez-Jiménez, J, Serrano, J, Tabernero, M, et al. (2008) Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors. Nutrition 24, 646–653.
29López-Oliva, M, Agis-Torres, A, García-Palencia, P, et al. (2006) Induction of epithelial hypoplasia in rat cecal and distal colonic mucosa by grape antioxidant dietary fiber. Nutr Res 26, 653–658.
30Schafer, FQ & Buettner, GR (2001) Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 30, 1191–1212.
31Saura-Calixto, F & Larrauri-García, JA (1999) .
32Saura-Calixto, F & Goñi, I (2006) .
33Re, R, Pellegrini, N, Proteggente, A, et al. (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26, 1231–1237.
34Ou, B, Hampsch-Woodill, M & Prior, RL (2001) Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem 49, 4619–4626.
35Prosky, L, Asp, N-G, Schweizer, TF, et al. (1992) Determination of insoluble and soluble dietary fiber in foods and food products: collaborative study. J Assoc Off Anal Chem 75, 360–367.
36Mañas, E & Saura-Calixto, F (1993) Ethanolic precipitation: a source of error in dietary fiber determination. Food Chem 47, 351–355.
37Saura-Calixto, F, Serrano, J & Goñi, I (2007) Intake and bioaccessibility of total polyphenols in a whole diet. Food Chem 101, 492–501.
38Montreau, FR (1972) Sur le dosage des composés phénoliques totaux dans les vins par la méthode Folin–Ciocalteau (The content of total phenolic compounds in wines measured by the Folin-Ciocalteau method). Connaiss Vigne Vin 24, 397–404.
39Lamuela-Raventos, RM & Waterhouse, AL (1994) A direct HPLC separation of wine phenolics. Am J Enol Viticult 45, 1–5.
40Reeves, PG, Nielsen, FH & Fahey, GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939–1951.
41AOAC (1990) Official Methods of Analysis, 15th ed.Washington, DC: Association of Official Analytical Chemists.
42Bradford, MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding. Anal Biochem 72, 248–254.
43Baker, MA, Cerniglia, GJ & Zaman, A (1990) Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem 190, 360–365.
44Wang, X, Wang, Q, Andersson, R, et al. (1993) Intramucosal pH and oxygen extraction in the gastrointestinal tract after major liver resection in rats. Eur J Surg 159, 81–87.
45Rost, J & Rapoport, S (1964) Reduction-potential of glutathione. Nature 201, 185.
46Flohe, L & Otting, F (1984) Superoxide dismutase assays. Methods Enzymol 105, 93–104.
47Flohe, L & Gunzler, WA (1984) Assays of glutathione peroxidase. Methods Enzymol 105, 114–121.
48Aebi, H (1984) Catalase in vitro. Methods Enzymol 105, 121–126.
49Nagata, H, Takekoshi, S, Takagi, T, et al. (1999) Antioxidative action of flavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidase. Tokai J Exp Clin Med 24, 1–11.
50Jonas, CR, Estivariz, CF, Jones, DP, et al. (1999) Keratinocyte growth factor enhances glutathione redox state in rat intestinal mucosa during nutritional repletion. J Nutr 129, 1278–1284.
51Faria, A, Monteiro, R, Mateus, N, et al. (2007) Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress. Eur J Nutr 46, 271–278.
52Wu, G, Fang, YZ, Yang, S, et al. (2004) Glutathione metabolism and its implications for health. J Nutr 134, 489–492.
53Abdel-Kader, R, Hauptmann, S, Keil, U, et al. (2007) Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761). Pharmacol Res 56, 493–502.
54Gerard-Monnier, D & Chaudiere, J (1996) Metabolism and antioxidant function of glutathione. Pathol Biol (Paris) 44, 77–85.
55Liu, X, Kim, CN, Yang, J, et al. (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86, 147–157.
56Du, Y, Guo, H & Lou, H (2007) Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes. J Agric Food Chem 55, 1695–1701.
57Kokoszka, JE, Coskun, P, Esposito, LA, et al. (2001) Increased mitochondrial oxidative stress in the Sod2 (+/ − ) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc Natl Acad Sci USA 98, 2278–2283.
58Wang, TG, Gotoh, Y, Jennings, MH, et al. (2000) Lipid hydroperoxide-induced apoptosis in human colonic CaCo-2 cells is associated with an early loss of cellular redox balance. FASEB J 14, 1567–1576.
59Circu, ML, Rodriguez, C, Maloney, R, et al. (2008) Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis. Free Radic Biol Med 44, 768–778.