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The gastroprotective effect of the essential oil of Croton cajucara is different in normal rats than in malnourished rats

  • A. C. B. Paula (a1) (a2), W. Toma (a1), J. S. Gracioso (a1), C. A. Hiruma-Lima (a2), E. M. Carneiro (a1) and A. R. M. Souza Brito (a1)...

Abstract

It has been shown previously that malnourished rats are resistant to acute gastric lesions but not to subchronic gastric ulceration. It also has been demonstrated that the essential oil obtained from the bark of Croton cajucara (Sacaca) has antiulcer properties. In the present study, the ability of this essential oil to prevent the formation of gastric ulcers in rats fed a diet with 17% protein (normoproteic rats) or 6% protein (malnourished rats) was investigated. At a dose of 100mg/kg body weight, orally, the essential oil significantly reduced the gastric injury caused by indomethacin (25% after 2h and 70% after 4h) only in normoproteic rats. In the pylorus ligature model, the essential oil increased the pH and gastric volume, but decreased the total acid concentration in both groups when compared to the respective control group. The essential oil significantly increased prostaglandin E2 production in glandular cells by 50% compared to the controls in both groups of rats. In addition, the amount of gastric mucus was two-fold higher in malnourished rats than in normoproteic rats. The present results show that the enhanced protective effect of essential oil in malnourished rats involved an increase in prostaglandin E2 production and mucus secretion, which are both factors that protect the gastric mucosa against damage. In agreement with this, malnourished rats always had a lower number of acute gastric ulcers.

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Corresponding author

*Corresponding author: Dr A. R. M. Souza Brito, fax +55 19 3788 6185, email abrito@unicamp.br

References

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Bagchi, M, Milnes Mark, BS, Williams Casey, BS, Balmoori Jaya, MS, Ye Xumei, BS, Stahs, S, Bagchi, DAcute and chronic stress-induced oxidative gastrointestinal injury in rats, and the protective ability of a novel grape seed proanthocyanidin extract. Nutr Res (1999) 19 11891199.
Carvalho, JC, Silva, MF, Maciel, MA, Pinto, A, Nunes, DS, Lima, RM, Bastos, JK, Sarti, SJInvestigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucaraPart 1.Planta Med (1996) 62 402404.
Curtis, GM, MacNaughton, WK, Grant Gall, D, Wallace, JLIntraluminal pH modulates gastric prostaglandin synthesis. Can J Physiol Pharmacol (1995) 73, 130134.
Desai, M, Crowther, NJ, Lucas, A, Hales, CNOrgan-selective growth in the offspring of protein-restricted mothers. Br J Nutr (1996) 76 591603.
Di Stasi, LC, Santos, EMC, Moreira dos Santos, C, Hiruma-Lima, CAIn Plantas Medicinais da Amazônia. 127128Saõ PauloEditora UNESP (1989)
Filaretova, LP, Podvigina, TT, Bagaeva, TR, Tanaka, A, Takeuchi, KMechanisms underlying the gastroprotective action of glucocorticoids released in response to ulcerogenic stress factors. Ann N Y Acad Sci (2004) 1018 288292.
Hales, CM, Barker, DJType 2 (non-insulin dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia (1992) 35 595601.
Hayden, LJ, Thomas, G, West, GBInhibitors of gastric lesions in the rat. J Pharm Pharmacol (1978) 30 244246.
Hiruma-Lima, CA, Gracioso, JS, Bighetti, EJ, Grassi-Kassisse, DM, Nunes, DS, Brito, AREffect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa. Phytomedicine (2002) 9 523529.
Hiruma-Lima, CA, Gracioso, JS, Bighetti, EJ, Grassi-Kassisse, DM, Nunes, DS, Souza Brito, ARMAntiulcerogenic mechanisms of essential oil from Croton cajucara. J Pharm Pharmacol (1999 a) 51 17.
Hiruma-Lima, CA, Gracioso, JS, Nunes, DS, Souza Brito, AREffects of an essential oil from the bark of Croton cajucara Benth.on experimental gastric ulcer models in rats and mice. J Pharm Pharmacol (1999 b) 51 341346.
Hiruma-Lima, CA, Gracioso, JS, Rodriguez, JA, Haun, M, Nunes, DS, Souza Brito, ARMGastroprotective effect of essential oil from Croton cajucara Benth. (Euphorbiaceae). J Ethnopharmacol (2000) 69 229234.
Paula, AC, Gracioso, JS, Toma, W, Bezerra, R, Saad, MA, De Lucca, IM, Carneiro, EM, Souza Brito, ARMIs gastric ulceration different in normal and malnourished rats?. Br J Nutr (2005) 93 4752.
Rafatullah, S, Tariq, M, Morra, JS, Al-Yahia, MA, Al-Sard, MS, Ageel, AMAnti-secretagogue, anti-ulcer and cytoprotective properties of Acorus calamus in rats. Fitoterapia (1999) 65 1923.
Rainsford, KD, The effects of aspirin and other non-steroid antiinflammatory/analgesic drugs on gastro-intestinal mucus glycoprotein biosynthesis in vivo: relationship to ulcerogenic actions. Biochem Pharmacol (1978) 27, 877885.
Reeves, PG, Nielsen, FH, Fahey, GCJr AIN-93 purified diets for laboratory rodents: report of the American Institute of Nutrition ad hoc working committee on the reformulation of the AIN-76 Arodent diet. J Nutr (1993) 123 19391951.
Sant'Ana, DMG, de Miranda-Neto, MH, de Souza, RR, Molinari, SLMorphological and quantitative study of the myenteric plexus of the ascending colon of rats subjected to protein desnutrition. Arq Neuropsiquiatr (1997) 55 687695.
Schubert, MLGastric secretion. Curr Opin Gastroenterol (2004) 20 519525.
Selye, H, Szabo, SExperimental model for production of perforating duodenal ulcers by cysteamine in the rat. Nature (1973) 244 458459.
Shay, H, Komarov, SA, Fels, SS, Meranze, D, Gruenstein, M, Siplet, HA simple method for the uniform production of gastric ulceration in the rat. Gastroenterology (1945) 5 4361.
Simões, JC, Silva, AJR, Serruya, H, Bents, MHSDesidrocrotonina, um norditerpeno de Croton cajucara Benth. (Euphorbiaceae). Cienc Cult (1979) 31 11401141.
Singh, S, Majumdar, DKEvaluation of the gastric anti-ulcer activity of fixed oil of Ocimum sanctum (Holy Basil). J Ethnopharmacol (1999) 65, 1319.
Souza Brito, ARM, Nunes, DSEthnopharmacology and sustainable development of new plant-derived drug. Cienc Cult (1997) 49 402408.
Szelenyi, T, Thiemer, KDistention ulcer as a model for testing of drugs for ulcerogenic side effects. Arch Toxicol (1978) 41 99105.
Takeeda, M, Hayashi, Y, Yamato, M, Murakami, M, Takeuchi, KRoles of endogenous prostaglandins and cyclooxygenase izoenzymes in mucosal defense of inflamed rat stomach. J Physiol Pharmacol (2004) 55 193205.
Takeeda, M, Yamato, M, Kato, S, Takeuchi, KCyclooxygenase isozymes involved in adaptive functional responses in rat stomach after barrier disruption. J Pharmacol Exp Ther (2003) 307 713719.
Wallace, JLProstaglandins, NSAIDs, and cytoprotection. Gastroenterol. Clin North Am (1992) 21, 631641.
Yoshitake, YI, Ohishi, E, Kubo, KHepatoprotective effects of 1-[(2-thiazolin-2- yl)-amino]cetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) in various experimental liver injuries. Jpn J Pharmacol (1991) 57 127136.
Zimmermann, MEthical guidelines for investigations of experimental pain in conscious animals. Pain (1983) 16 109110.

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