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A fermented milk concentrate and a combination of short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides/pectin-derived acidic oligosaccharides protect suckling rats from rotavirus gastroenteritis

  • Mar Rigo-Adrover (a1) (a2), Teresa Pérez-Berezo (a1) (a2), Sara Ramos-Romero (a1) (a2), Kees van Limpt (a3), Karen Knipping (a3) (a4), Johan Garssen (a3) (a4), Jan Knol (a3), Àngels Franch (a1) (a2), Margarida Castell (a1) (a2) and Francisco J. Pérez-Cano (a1) (a2)...

Abstract

Human milk contains bioactive compounds that confer a protective role against gastrointestinal infections. In order to find supplements for an infant formula able to mimic these benefits of breast-feeding, two different concepts were tested. The products consisted of the following: (1) a Bifidobacterium breve- and Streptococcus thermophilus-fermented formula and (2) a combination of short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides with pectin-derived acidic oligosaccharides. A rotavirus infection suckling rat model was used to evaluate improvements in the infectious process and in the immune response of supplemented animals. Both nutritional concepts caused amelioration of the clinical symptoms, even though this was sometimes hidden by softer stool consistency in the supplemented groups. Both products also showed certain modulation of immune response, which seemed to be enhanced earlier and was accompanied by a faster resolution of the process. The viral shedding and the in vitro blocking assay suggest that these products are able to bind the viral particles, which can result in a milder infection. In conclusion, both concepts evaluated in this study showed interesting protective properties against rotavirus infection, which deserve to be investigated further.

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Corresponding author

* Corresponding author: F. J. Pérez-Cano, fax +34 93 403 59 01, email franciscoperez@ub.edu

References

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Keywords

A fermented milk concentrate and a combination of short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides/pectin-derived acidic oligosaccharides protect suckling rats from rotavirus gastroenteritis

  • Mar Rigo-Adrover (a1) (a2), Teresa Pérez-Berezo (a1) (a2), Sara Ramos-Romero (a1) (a2), Kees van Limpt (a3), Karen Knipping (a3) (a4), Johan Garssen (a3) (a4), Jan Knol (a3), Àngels Franch (a1) (a2), Margarida Castell (a1) (a2) and Francisco J. Pérez-Cano (a1) (a2)...

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