1Baird, G, Simonoff, E, Pickles, A, et al. (2006) Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 368, 210–215.
2Harrison, MJ, O'Hare, AE, Campbell, H, et al. (2006) Prevalence of autistic spectrum disorders in Lothian, Scotland an estimate using the ‘capture–recapture’ technique. Arch Dis Child 91, 16–19.
3Baron-Cohen, S, Scott, FJ, Alison, C, et al. (2009) Prevalence of autism-spectrum conditions: UK school-based population study. Br J Psych 194, 500–509.
4Blaxhill, MF, Baskin, DS & Spitzer, WO (2003) The changing prevalence of autism in California. J Autism Dev Disorders 33, 223–226.
5Richardson, AJ & Ross, MA (2000) Fatty acid metabolism in neurodevelopmental disorder: a new perspective on associations between attention-deficit/hyperactivity disorder, dyslexia, dyspraxia and the autistic spectrum. Prostaglandins Leukot Essent Fatty Acids 63, 1–9.
6Young, G & Conquer, J (2005) Omega-3 fatty acids and neuropsychiatric disorders. Reprod Nutr Dev 45, 1–28.
7Horrobin, DF & Bennett, CN (2003) . In Phospholipid Spectrum Disorders in Psychiatry and Neurology, pp. 3–47 [Peet, M, Glen, IAM and Horrobin, DF, editors]. Carnforth: Marius Press.
8Uauy, R & Dangour, AD (2006) Nutrition in brain development and aging: role of essential fatty acids. Nutr Rev 64, S24–S33.
9Ruxton, CHS, Calder, PC, Reed, SC, et al. (2005) The impact of long-chain n-3 polyunsaturated fatty acids on human health. Nutr Res Rev 18, 113–129.
10Sprecher, H (1999) An update on the pathways of polyunsaturated fatty acid metabolism. Curr Opin Clin Nutr Metab Care 2, 135–138.
11Pawolsky, RJ, Hibbeln, JR, Novotny, JA, et al. (2001) Physiological compartmental analysis of α-linolenic acid metabolism in adult humans. J Lipid Res 42, 1257–1265.
12Burdge, GC, Jones, AE & Wootton, SA (2002) Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men. Br J Nutr 88, 355–363.
13Burdge, GC & Wootton, SA (2002) Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr 88, 411–420.
14Constantino, JN & Todd, RD (2003) Autistic traits in the general population: a twin study. Arch Gen Psychiatry 60, 524–530.
15Kim, HY (2007) Novel metabolism of docosahexaenoic acid in neural cells. J Biol Chem 282, 18661–18665.
16Orr, SK & Bazinet, RP (2008) The emerging role of docosahexaenoic acid in neuroinflammation. Curr Opinion Invest Drugs 9, 735–743.
17Bazan, NG (2005) Lipid signalling in neural plasticity, brain repair, and neuroprotection. Mol Neurobiol 32, 89–103.
18Brookes, KJ, Chen, W, Xu, X, et al. (2006) Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder. Biol Psychiatry 60, 1053–1061.
19Scaeffer, L, Gohlke, H, Muller, M, et al. (2006) Common genetic variants of the FADS1 FADS 2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Human Mol Genetics 15, 1745–1756.
20Vancassel, S, Durand, G, Barthelemy, C, et al. (2001) Plasma fatty acid levels in autistic children. Prostaglandins Leukot Essent Fatty Acids 65, 1–7.
21Bell, JG, MacKinlay, EE, Dick, JR, et al. (2004) Essential fatty acids and phospholipase A2 in autistic spectrum disorders. Prostaglandins Leukot Essent Fatty Acids 71, 201–204.
22Bu, B, Ashwood, P, Harvey, D, et al. (2006) Fatty acid compositions of red blood cell phospholipids in children with autism. Prostaglandins Leukot Essent Fatty Acids 74, 215–221.
23Lord, C, Rutter, M & Le Couteur, A (1994) Autism Diagnostic Interview – Revised: a revised version of a diagnostic interview for care givers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24, 659–685.
25World Health Organization (1993) The ICD-10 Classification of Mental and Behavioural Disorders – Diagnostic Criteria for Research. Geneva, Switzerland: WHO.
26American Psychiatric Association (1994) Diagnostic and Statistical Manual for Mental Disorders (DSM-IV), 4th ed. Washington, DC: APA.
27Harrison, MJ, O'Hare, AE, Campbell, H, et al. (2006) Prevalence of autistic spectrum disorders in Lothian, Scotland and estimated using the capture–recapture technique. Arch Dis Child 91, 16–19.
28Goodman, R, Ford, T & Simmons, H (2000) Using the Strengths and Difficulties Questionnaire (SDQ) to screen for child psychiatric disorders in a community sample. Br J Psychiatry 177, 534–539.
29Sparrow, SS & Cicchetti, DV (1985) Diagnostic uses of the Vineland Adaptive Behaviour Scales. J Pediatr Psychol 10, 215–225.
30Bligh, EG & Dyer, WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37, 911–917.
31Folch, J, Lees, M & Sloane Stanley, GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497–509.
32Christie, WW (2003) . In Lipid Analysis, 3rd ed., pp. 205–224 [PJ Barnes, editor]. Bridgwater, UK: The Oily Press.
33Aupperle, RL, Denney, DR, Lynch, SG, et al. (2008) Omega-3 fatty acids and multiple sclerosis: relationship to depression. J Behav Med 31, 127–135.
34Clayton, EH, Hanstock, TL, Hirneth, SJ, et al. (2008) Long-chain omega-3 polyunsaturated fatty acids in the blood of children and adolescents with juvenile bipolar disorder. Lipids 43, 1031–1038.
35Cyhlarova, E, Bell, JG, Dick, JR, et al. (2007) Membrane fatty acids, reading and spelling in dyslexic and non-dyslexic adults. Eur Neuropsychopharmacol 17, 116–121.
36Calder, PC (2003) n-3 Polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids 38, 342–352.
37Galli, C, Marangoni, F & Petroni, A (1992) Modulation of arachidonic acid metabolism in cultured rat astroglial cells by long-chain n-3 fatty acids. Adv Exp Med Biol 318, 115–120.
38Jump, DB (2002) The biochemistry of n-3 polyunsaturated fatty acids. J Biol Chem 277, 8755–8758.
39Allessandri, J-M, Guesnet, P, Vancassel, S, et al. (2004) Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life. Reprod Nutr Dev 44, 509–548.
40Ledeen, RW, Yu, RK & Eng, LF (1973) Gangliosides of human myelin: sialosyl galactosylceramide (G7) as a major component. J Neurochem 21, 829–839.
41Clark-Taylor, T & Clark-Taylor, BE (2004) Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial β-oxidation by long chain acyl-CoA dehydrogenase. Med Hypotheses 62, 970–975.
42Shao, L, Martin, MV, Watson, SJ, et al. (2008) Mitochondrial involvement in psychiatric disorders. Ann Med 40, 281–295.
43Stevens, L, Zhang, W, Peck, L, et al. (2003) EFA supplementation in children with inattention, hyperactivity and other disruptive behaviours. Lipids 38, 1007–1021.
44Panchaud, A, Sauty, A, Kernan, Y, et al. (2006) Biological effects of a dietary omega-3 polyunsaturated fatty acids supplementation in cystic fibrosis patients: a randomized, crossover placebo-controlled trial. Clin Nutr 25, 418–427.
45Katan, MB, Deslypere, JP, van Birgelen, AP, et al. (1997) Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18 month controlled study. J Lipid Res 38, 2012–2022.
46Stevens, LJ, Zental, SS, Deck, JL, et al. (1995) Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 62, 761–768.
47Puri, B & Richardson, AJ (2003) . In Phospholipid Spectrum Disorders in Psychiatry and Neurology, pp. 377–390 [Peet, M, Glen, IAM and Horrobin, DF, editors]. Carnforth, UK: Marius Press.
48Herndon, AC, Di Guiseppi, C, Johnson, SL, et al. (2009) Does nutritional intake differ between children with autism spectrum disorders and children with typical development? J Autism Dev Disord 39, 212–222.
49Pontes, PV, Torres, AG, Trugo, NMF, et al. (2006) n-6 and n-3 Long-chain polyunsaturated fatty acids in the erythrocyte membrane of Brazilian preterm and term neonates and their mothers at delivery. Prostaglandins Leukot Essent Fatty Acids 74, 117–123.
50Smithers, LG, Gibson, RA, McPhee, A, et al. (2008) Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: results from the DINO trial. Prostaglandins Leukot Essent Fatty Acids 79, 141–146.
51Bent, S, Bertoglio, K & Hendren, RL (2009) Omega-3 fatty acids for autistic spectrum disorder: a systematic review. J Autism Dev Disord 39, 1145–1154.
52Moriguchi, T, Greiner, RS & Salem, N Jr (2000) Behavioural deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. J Neurochem 75, 2563–2573.
53Richardson, AJ & Puri, BK (2002) A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry 26, 233–239.