1 Schlimme, E, Martin, D & Meisel, H (2000) Nucleosides and nucleotides: natural bioactive substances in milk and colostrum. Br J Nutr 84, Suppl. 1, S59–S68.
2 Sánchez-Pozo, A & Gil, A (2002) Nucleotides as semiessential nutritional components. Br J Nutr 87, Suppl. 1, S135–S137.
3 Gil, A (2002) Modulation of the immune response mediated by dietary nucleotides. Eur J Clin Nutr 56, Suppl. 3, S1–S4.
4 Evans, ME, Jones, DP & Ziegler, TR (2005) Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway. Am J Physiol Gastrointest Liver Physiol 289, G388–G396.
5 Nunez, MC, Bueno, JD, Ayudarte, MV, Almendros, A, Rios, A, Suarez, MD & Gil, A (1996) Dietary restriction induces biochemical and morphometric changes in the small intestine of nursing piglets. J Nutr 126, 933–944.
6 Arnaud, A, Lopez-Pedrosa, JM, Torres, MI & Gil, A (2003) Dietary nucleotides modulate mitochondrial function of intestinal mucosa in weanling rats with chronic diarrhea. J Pediatr Gastroenterol Nutr 37, 124–131.
7 Mabley, JG, Pacher, P, Liaudet, L, Soriano, FG, Hasko, G, Marton, A, Szabo, C & Salzman, AL (2003) Inosine reduces inflammation and improves survival in a murine model of colitis. Am J Physiol-Gastrointest Liver Physiol 284, G138–G144.
8 Dowdall, JF, Winter, DC & Bouchier-Hayes, DJ (2002) Inosine modulates gut barrier dysfunction and end organ damage in a model of ischemia-reperfusion injury. J Surg Res 108, 61–68.
9 Belo, A, Marchbank, T, Fitzgerald, A, Ghosh, S & Playford, RJ (2006) Gastroprotective effects of oral nucleotide administration. Gut 55, 165–171.
10 Arnaud, A, Fontana, L, Angulo, AJ, Gil, A & Lopez-Pedrosa, JM (2003) Exogenous nucleosides alter the intracellular nucleotide pool in hepatic cell cultures. Implications in cell proliferation and function. Clin Nutr 22, 391–399.
11 Saez-Lara, MJ, Manzano, M, Angulo, AJ, Suarez, A, Torres, MI, Gomez-Llorente, C, Gil, A & Fontana, L (2004) Exogenous nucleosides stimulate proliferation of fetal rat hepatocytes. J Nutr 134, 1309–1313.
12 Gil, A, Gómez-León, C & Rueda, R (2007) Exogenous nucleic acids and nucleotides are efficiently hydrolysed and taken up as nucleosides by intestinal explants from suckling piglets. Br J Nutr 98, 285–291.
13 Sato, N, Nakano, T, Kawakami, H & Idota, T (1999) In vitro and in vivo effects of exogenous nucleotides on the proliferation and maturation of intestinal epithelial cells. J Nutr Sci Vitaminol (Tokyo) 45, 107–118.
14 He, Y, Chu, SH & Walker, WA (1993) Nucleotide supplements alter proliferation and differentiation of cultured human (Caco-2) and rat (IEC-6) intestinal epithelial cells. J Nutr 123, 1017–1027.
15 Boza, JJ, Moennoz, D, Bournot, CE, Blum, S, Zbinden, I, Finot, PA & Ballevre, O (2000) Role of glutamine on the de novo purine nucleotide synthesis in Caco-2 cells. Eur J Nutr 39, 38–46.
16 Tanaka, M, Lee, K, Martinez-Augustin, O, He, Y, Sanderson, IR & Walker, WA (1996) Exogenous nucleotides alter the proliferation, differentiation and apoptosis of human small intestinal epithelium. J Nutr 126, 424–433.
17 Chen, X, Wang, R, Deng, M & Ran, X (2001) Effects of exogenous adenosine 5′-monophosphate on proliferation and apoptosis of small intestinal epithelial cells. Wei Sheng Yan Jiu 30, 165–167.
18 Duchen, K & Thorell, L (1999) Nucleotide and polyamine levels in colostrum and mature milk in relation to maternal atopy and atopic development in the children. Acta Paediatr 88, 1338–1343.
19 Gehrke, C & Kuo, K () (1990) Chromatography and Modification of Nucleosides, Part A, B and C Analytical Methods for Major and Modified Nucleosides HPLC, GC, MS, NMR and FT-IR. Amsterdam: Elsevier.
20 Perret, D (1993) Nucleotides, nucleosides and bases. In High Performance Liquid Chromatography in Neuroscience Research, pp. 163–165 [Holman, RB, Cross, AJ and Joseph, MH, editors]. London: Wiley.
21 Goldstein, R, Klein, T, Freier, S & Menczel, J (1971) Alkaline phosphatase and dissaccharidase activities in the rat intestine from birth to weaning. I. Effect of diet on enzyme development. Am J Clin Nutr 24, 1224–1231.
22 Brown, RE, Jarvis, KL & Hyland, KJ (1989) Protein measurement using bicinchoninic acid: elimination of interfering substances. Anal Biochem 180, 136–139.
23 Aymerich, I, Pastor-Anglada, M & Casado, FJ (2004) Long term endocrine regulation of nucleoside transporters in rat intestinal epithelial cells. J Gen Physiol 124, 505–512.
24 Sterling, KM Jr & Cutroneo, KR (2002) Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis. J Cell Biochem 86, 440–450.
25 Aymerich, I, Duflot, S, Fernandez-Veledo, S, Guillen-Gomez, E, Huber-Ruano, I, Casado, FJ & Pastor-Anglada, M (2005) The concentrative nucleoside transporter family (SLC28): new roles beyond salvage? Biochem Soc Trans 33, 216–219.
26 Aymerich, I, Foufelle, F, Ferre, P, Casado, FJ & Pastor-Anglada, M (2006) Extracellular adenosine activates AMP-dependent protein kinase (AMPK). J Cell Sci 119, 1612–1621.
27 Larrayoz, IM, Fernandez-Nistal, A, Garces, A, Gorraitz, E & Lostao, MP (2006) Characterization of the rat Na+/nucleoside cotransporter 2 and transport of nucleoside-derived drugs using electrophysiological methods. Am J Physiol Cell Physiol 291, C1395–C1404.
28 Ohyanagi, H, Nishimatsu, S, Kanbara, Y, Usami, M & Saitoh, Y (1989) Effects of nucleosides and a nucleotide on DNA and RNA syntheses by the salvage and de novo pathway in primary monolayer cultures of hepatocytes and hepatoma cells. JPEN J Parenter Enteral Nutr 13, 51–58.
29 Mayer, D, Natsumeda, Y, Ikegami, T, Faderan, M, Lui, M, Emrani, J, Reardon, M, Olah, E & Weber, G (1990) Expression of key enzymes of purine and pyrimidine metabolism in a hepatocyte-derived cell line at different phases of the growth cycle. J Cancer Res Clin Oncol 116, 251–258.
30 Moyer, JD, Oliver, JT & Handschumacher, RE (1981) Salvage of circulating pyrimidine nucleosides in the rat. Cancer Res 41, 3010–3017.
31 Pels Rijcken, WR, Overdijk, B, Van den Eijnden, DH & Ferwerda, W (1995) The effect of increasing nucleotide-sugar concentrations on the incorporation of sugars into glycoconjugates in rat hepatocytes. Biochem J 305, 865–870.
32 Karle, JM, Anderson, LW & Cysyk, RL (1984) Effect of plasma concentrations of uridine on pyrimidine biosynthesis in cultured L1210 cells. J Biol Chem 259, 67–72.
33 Hallett, MA, Dagher, PC & Atkinson, SJ (2003) Rho GTPases show differential sensitivity to nucleotide triphophate depletion in a model of ischemic cell injury. Am J Physiol Cell Physiol 285, C129–C138.
34 Hucul, JA, Henshaw, EC & Young, DA (1985) Nucleoside diphosphate regulation of overall rates of protein biosynthesis acting at the level of initiation. J Biol Chem 260, 15585–15591.
35 Sato, N, Kawakami, H & Idota, A (2000) Nucleotide and nucleoside supplementation may morphologically promote the differentiation of human caco-2 cells. J Nutr Sci Vitaminol (Tokyo) 46, 175–179.
36 Vieites, JM, Sanchez-Pozo, A, Gil, A & Suarez, A (2005) Development of a protocol for the analysis of genetic expression by differential display. Ars Pharm 46, 193–204.
37 Perez, MJ, Suarez, A, Gomez-Capilla, JA, Sanchez-Medina, F & Gil, A (2002) Dietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats. J Nutr 132, 652–657.
38 Perez, MJ, Sanchez-Medina, F, Torres, M, Gil, A & Suarez, A (2004) Dietary nucleotides enhance the liver redox state and protein synthesis in cirrhotic rats. J Nutr 134, 2504–2508.
39 Grimble, GK (1994) Dietary nucleotides and gut mucosal defence. Gut 35, S46–S51.