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Effects of potassium chloride and potassium bicarbonate in the diet on urinary pH and mineral excretion of adult cats

  • Nadine Paßlack (a1), Thomas Brenten (a2), Konrad Neumann (a3) and Jürgen Zentek (a1)

Abstract

Low dietary K levels have been associated with increasing renal Ca excretion in humans, indicating a higher risk of calcium oxalate (CaOx) urolith formation. Therefore, the present study aimed to investigate whether dietary K also affects the urine composition of cats. A total of eight adult cats were fed diets containing 0·31 % native K and 0·50, 0·75 and 1·00 % K from KCl or KHCO3 and were evaluated for the effects of dietary K. High dietary K levels were found to elevate urinary K concentrations (P< 0·001). Renal Ca excretion was higher in cats fed the KCl diets than in those fed the KHCO3 diets (P= 0·026), while urinary oxalate concentrations were generally lower in cats fed the KCl diets and only dependent on dietary K levels in cats fed the KHCO3 diets (P< 0·05). Fasting urine pH increased with higher dietary K levels (P= 0·022), reaching values of 6·38 (1·00 % KCl) and 7·65 (1·00 % KHCO3). K retention was markedly negative after feeding the cats with the basal diet ( − 197 mg/d) and the 0·50 % KCl diet ( − 131 mg/d), while the cats tended to maintain their balance on being fed the highest-KCl diet ( − 23·3 mg/d). In contrast, K from KHCO3 was more efficiently retained (P= 0·018), with K retention being between − 82·5 and 52·5 mg/d. In conclusion, the dietary inclusion of KHCO3 instead of KCl as K source could be beneficial for the prevention of CaOx urolith formation in cats, since there is an association between a lower renal Ca excretion and a generally higher urine pH. The utilisation of K is distinctly influenced by the K salt, which may be especially practically relevant when using diets with low K levels.

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Corresponding author

* Corresponding author: Dr N. Paßlack, fax +49 3083855938, email nadine.passlack@fu-berlin.de

References

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1 Dijcker, JC, Plantinga, EA, van Baal, J, et al. (2011) Influence of nutrition on feline calcium oxalate urolithiasis with emphasis on endogenous oxalate synthesis. Nutr Res Rev 24, 96110.
2 Lekcharoensuk, C, Osborne, CA, Lulich, JP, et al. (2001) Association between dietary factors and calcium oxalate and magnesium ammonium phosphate urolithiasis in cats. J Am Vet Med Assoc 219, 12281237.
3 Passlack, N & Zentek, J (2013) Urinary calcium and oxalate excretion in healthy adult cats are not affected by increasing dietary calcium levels. PLoS ONE 8, e70530.
4 Dijcker, JC, Hagen-Plantinga, EA & Hendriks, WH (2012) Changes in dietary macronutrient profile do not appear to affect endogenous urinary oxalate excretion in healthy adult cats. Vet J 194, 235239.
5 Dijcker, JC, Hagen-Plantinga, EA, Everts, H, et al. (2012) Dietary and animal-related factors associated with the rate of urinary oxalate and calcium excretion in dogs and cats. Vet Rec 171, 4652.
6 Stevenson, AE, Blackburn, JM, Markwell, PJ, et al. (2004) Nutrient intake and urine composition in calcium oxalate stone-forming dogs: comparison with healthy dogs and impact of dietary modification. Vet Ther 5, 218231.
7 Morozumi, M, Hossain, RZ, Yamakawa, K, et al. (2006) Gastrointestinal oxalic acid absorption in calcium-treated rats. Urol Res 34, 168172.
8 Penniston, KL & Nakada, SY (2009) Effect of dietary changes on urinary oxalate excretion, and calcium oxalate supersaturation in patients with hyperoxaluric stone formation. Urology 73, 484489.
9 Liebman, M & Chai, W (1997) Effect of dietary calcium on urinary oxalate excretion after oxalate loads. Am J Clin Nutr 65, 14531459.
10 Liebman, M & Costa, G (2000) Effects of calcium and magnesium on urinary oxalate excretion after oxalate loads. J Urol 163, 15651569.
11 Holmes, RP, Goodman, HO & Assimos, DG (2001) Contribution of dietary oxalate to urinary oxalate excretion. Kidney Int 59, 270276.
12 Masai, M, Ito, H & Kotake, T (1995) Effect of dietary intake on urinary oxalate excretion in calcium renal stone formers. Br J Urol 76, 692696.
13 Naya, Y, Naya, Y, Ito, H, et al. (2002) Association of dietary fatty acids with urinary oxalate excretion in calcium oxalate stone-formers in their fourth decade. BJU Int 89, 842846.
14 Lemann, J Jr, Pleuss, JA, Gray, RW, et al. (1991) Potassium administration reduces and potassium deprivation increases urinary calcium excretion in healthy adults [corrected]. Kidney Int 39, 973983.
15 Lemann, J Jr, Pleuss, JA & Gray, RW (1993) Potassium causes calcium retention in healthy adults. J Nutr 123, 16231626.
16 Osborne, CA, Kruger, JM, Lulich, JP, et al. (1995) Disorders of the feline lower urinary tract. In Canine and Feline Nephrology and Urology, pp. 625680 [Osborne, CA and Finco, DR, editors]. Baltimore: Williams and Wilkins.
17 Pietrow, PK & Karellas, ME (2006) Medical management of common urinary calculi. Am Fam Physician 74, 8694.
18 Poupin, N, Calvez, J, Lassale, C, et al. (2012) Impact of the diet on net endogenous acid production and acid–base balance. Clin Nutr 31, 313321.
19 Dow, SW, Fettman, MJ, Smith, KR, et al. (1990) Effects of dietary acidification and potassium depletion on acid–base balance, mineral metabolism and renal function in adult cats. J Nutr 120, 569578.
20 Von Engelhardt, W & Breves, G (editors) (2010) Physiologie der Haustiere (Physiology of Companion Animals). Stuttgart: MVS Medizinverlag Stuttgart GmbH & Co. KG.
21 Markwell, PJ, Buffington, CT & Smith, BH (1998) The effect of diet on lower urinary tract diseases in cats. J Nutr 128, 2753S2757S.
22 Naumann, C & Bassler, C (2004) Die chemische Untersuchung von Futtermitteln 3. Aufl., 5. Ergänzungslieferung (Chemical Feed Analyses, Vol. 3). Darmstadt: VDLUFA-Verlag.
23 National Research Council (NRC) (2006) Nutrient Requirements of Dogs and Cats. Washington, DC: The National Academic Press.
24 Gericke, S & Kurmies, B (1952) Colorimetrische Bestimmung der Phosphorsäure mit Vanadat-Molybdat (Colorimetric determination of phosphoric acid with vanadate molybdate). Fres Zeitsch Anal Chem 137, 1522.
25 Kirk, CA, Ling, GV, Franti, CE, et al. (1995) Evaluation of factors associated with development of calcium oxalate urolithiasis in cats. J Am Vet Med Assoc 207, 14291434.
26 Osborne, CA, Lulich, JP, Thumchai, R, et al. (1995) Etiopathogenesis and Therapy of Feline Calcium Oxalate Urolithiasis. Proceedings of 13th ACVIM Forum. Blacksburg, VA: ACVIM pp. 487489.
27 Field, MJ, Stanton, BA & Giebisch, GH (1984) Differential acute effects of aldosterone, dexamethasone, and hyperkalemia on distal tubular potassium secretion in the rat kidney. J Clin Investig 74, 17921802.
28 Giebisch, G (1998) Renal potassium transport: mechanisms and regulation. Am J Physiol 274, F817F833.
29 Woda, CB, Bragin, A, Kleyman, TR, et al. (2001) Flow-dependent K+ secretion in the cortical collecting duct is mediated by a maxi-K channel. Am J Physiol Renal Physiol 280, F786F793.
30 Takada, Y, Mori, T & Noguchi, T (1984) The effect of vitamin B6 deficiency on alanine:glyoxylate aminotransferase isoenzymes in rat liver. Arch Biochem Biophys 229, 16.
31 Bai, SC, Sampson, DA, Morris, JG, et al. (1989) Vitamin B-6 requirement of growing kittens. J Nutr 119, 10201027.
32 Bai, SC, Sampson, DA, Morris, JG, et al. (1991) The level of dietary protein affects the vitamin B-6 requirement of cats. J Nutr 121, 10541061.
33 Teerajetgul, Y, Hossain, RZ, Yamakawa, K, et al. (2007) Oxalate synthesis from hydroxypyruvate in vitamin-B6-deficient rats. Urol Res 35, 173178.
34 Auer, BL, Auer, D & Rodgers, AL (1998) Relative hyperoxaluria, crystalluria and haematuria after megadose ingestion of vitamin C. Eur J Clin Invest 28, 695700.
35 Baxmann, AC, De O G Mendonca, C & Heilberg, IP (2003) Effect of vitamin C supplements on urinary oxalate and pH in calcium stone-forming patients. Kidney Int 63, 10661071.
36 Chai, W, Liebman, M, Kynast-Gales, S, et al. (2004) Oxalate absorption and endogenous oxalate synthesis from ascorbate in calcium oxalate stone formers and non-stone formers. Am J Kidney Dis 44, 10601069.
37 Massey, LK, Liebman, M & Kynast-Gales, SA (2005) Ascorbate increases human oxaluria and kidney stone risk. J Nutr 135, 16731677.
38 Moyad, MA, Combs, MA, Crowley, DC, et al. (2009) Vitamin C with metabolites reduce oxalate levels compared to ascorbic acid: a preliminary and novel clinical urologic finding. Urol Nurs 29, 95102.
39 Yu, S & Gross, K (2005) Moderate dietary vitamin C supplement does not affect urinary oxalate concentrations in cats. J Anim Physiol Anim Nutr 89, 428429.
40 Tiselius, HG (1981) The effect of pH on the urinary inhibition of calcium oxalate crystal growth. Br J Urol 53, 470474.

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