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Effects of a high walnut and high cashew nut diet on selected markers of the metabolic syndrome: a controlled feeding trial

  • Janine Mukuddem-Petersen (a1) (a2), Welma Stonehouse (Oosthuizen) (a1) (a3), Johann C. Jerling (a1), Susanna M. Hanekom (a1) and Zelda White (a1)...


We investigated the effects of a high walnut diet and a high unsalted cashew nut diet on selected markers of the metabolic syndrome. In a randomized, parallel, controlled study design, sixty-four subjects having the metabolic syndrome (twenty-nine men, thirty-five women) with a mean age of 45 (sd 10) years and who met the selection criteria were all fed a 3-week run-in control diet. Hereafter, participants were grouped according to gender and age and then randomized into three groups receiving a controlled feeding diet including walnuts, or unsalted cashew nuts or no nuts for 8 weeks. Subjects were required to have lunch at the metabolic ward of the Nutrition Department of the North-West University (Potchefstroom Campus). Both the walnut and the unsalted cashew nut intervention diets had no significant effect on the HDL-cholesterol, TAG, total cholesterol, LDL-cholesterol, serum fructosamine, serum high-sensitivity C-reactive protein, blood pressure and serum uric acid concentrations when compared to the control diet. Low baseline LDL-cholesterol concentrations in the cashew nut group may have masked a possible nut-related benefit. Plasma glucose concentrations increased significantly (P = 0·04) in the cashew nut group compared to the control group. By contrast, serum fructosamine was unchanged in the cashew nut group while the control group had significantly increased (P = 0·04) concentrations of this short-term marker of glycaemic control. Subjects displayed no improvement in the markers of the metabolic syndrome after following a walnut diet or a cashew nut diet compared to a control diet while maintaining body weight.

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Corresponding author

*Corresponding author: Dr Janine Mukuddem-Petersen, School of Computer, Mathematical and Statistical Sciences, North-West University (Potchefstroom Campus), Private Bag X 6001, Potchefstroom, South Africa, fax +27 18 299 2570, email


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