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The effect of iron substrate on mitochondria1 haem synthesis in copper deficiency

  • Darryl M. Williams (a1), F. Scott Kennedy (a1) and Brenda G. Green (a1)

Abstract

1. Studies of iron utilization and haem synthesis were carried out with hepatic mitochondria obtained from copper-deficient and pair-fed control rats.

2. Ferric chloride can be used as Fe substrate for mitochondrial haem synthesis in the presence of succinate. Utilization is further enhanced by the addition of FMN.

3. Ferritin does not support haem synthesis in the presence of succinate alone, but does support haem synthesis when FMN is added.

4. Mitochondria1 haem synthesis is impaired in Cu deficiency when either FeCl3 or homologous ferritin is used as Fe substrate.

5. The results of the present study suggest that impaired haem synthesis in Cu deficiency occurs at a step following the chemical reduction of Fe substrate.

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References

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Baker, E., Morton, A. G. & Tavill, A. S. (1980). British Journal of Haematology 45, 607620.
Barnes, R. & Jones, O. T. G. (1973). Biochimica et Biophysica Acta 304, 304308.
Drysdale, J. W. & Munro, H. N. (1965). Biochemical Journal 95, 851858.
Evans, J. L. & Abraham, P. A. (1973). Journal of Nutrition 103, 196201.
Goodman, J. R. & Dallman, P. R. (1969). Blood 34, 747753.
Ibrahim, N. G., Friedland, M. L. & Levere, R. D. (1983). Progress in Hematology 13, 75130.
Jones, T., Spencer, R. & Walsh, C. (1978). Biochemistry 17, 40114017.
Lee, G. R., Williams, D. M. & Cartwright, G. E. (1976). In Trace Elements in Human Health and Disease, vol. 1, Zinc and Copper, pp. 373393 [Prasad, A. S. and Oberleas, D., editors]. New york: Academic press.
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Journal of Biological Chemistry 193, 265275.
Nunez, M. T., Glass, J. & Robinson, S. H. (1978). Biochimica et Biophysica Acta 509, 170180.
Osaki, S. & Johnson, D. A. (1969). Journal of Biological Chemistry 244, 57575765.
Porra, R. J. & Jones, O. T. G. (1963). Biochemical Journal 87, 181185.
Prohaska, J. R. (1983). Journal of Nutrition 113, 20482058.
Ravin, H. A. (1961). Journal of Laboratory and Clinical Medicine 58, 161168.
Roeser, H. P., Lee, G. R., Nacht, S. & Cartwright, G. E. (1970). Journal of Clinical Investigation 49, 24082417.
Romslo, I. & Flatmark, T. (1973). Biochimica et Biophysica Acta 305, 2940.
Romslo, I. & Husby, P. (1980). International Journal of Biochemistry 12, 709712.
Seligman, P. A. (1983). Progress in Hematology 13, 131417.
Sirivech, S., Driskell, J. & Frieden, E. (1977). Journal of Nutrition 107, 739745.
Ulvik, R. & Romslo, I. (1979). Biochimica et Biophysica Acta 588, 256271.
Wharton, D. C. & Tzagaloff, A. (1967). In Methods in Enzymology, vol. 10, pp. 245250 [Estabrook, R. W. and Pullman, M. E., editors]. New york: Academic Press.
Williams, D. M., Kennedy, F. S. & Green, B. G. (1983). British Journal of Nutrition 50, 653660.
Williams, D. M., Loukopoulos, D., Lee, G. R. & Cartwright, G. E. (1976). Blood 48, 7785.

The effect of iron substrate on mitochondria1 haem synthesis in copper deficiency

  • Darryl M. Williams (a1), F. Scott Kennedy (a1) and Brenda G. Green (a1)

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