Hostname: page-component-8448b6f56d-jr42d Total loading time: 0 Render date: 2024-04-16T19:37:00.866Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of dietary modification and hyperglycaemia on gastric emptying and gastric inhibitory polypeptide (GIP) secretion

Published online by Cambridge University Press:  09 March 2007

L. M. Morgan ,
J. A. T. Tredger ,
S. M. Hampton ,
A. P. French ,
J. C. F. Peake  and
V. Marks
L. M. Morgan
Affiliation:
Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH
J. A. T. Tredger
Affiliation:
Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH
S. M. Hampton
Affiliation:
Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH
A. P. French
Affiliation:
Department of Medical Physics, St Luke's Hospital, Guildford, Surrey
J. C. F. Peake
Affiliation:
Department of Medical Physics, St Luke's Hospital, Guildford, Surrey
V. Marks
Affiliation:
Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Five healthy volunteers whose usual fat and energy intakes were moderately high (fat intake 155 (SE 11) g/d; energy intake 13683 (SE 909) kJ/d) were given on two separate occasions (a) 96 g fat and (b) 96 g fat and intravenous (IV) glucose (250 g glucose/1; 100 ml followed by a 2 ml/min infusion for 180 min).

2. Subjects continued on a low-fat diet for 35 d (fat intake 25 (SE 4) g/d; energy intake 6976 (SE 539) kJ/d) and the tests repeated.

3. The gastric inhibitory polypeptide (GIP) response to oral fat was significantly attenuated by IV glucose whilst subjects were consuming their normal diets and the GIP response to fat alone was significantly diminished during the low-fat diet. Post-prandial plasma triglycerides, light scattering indices (LSI; an index of post-prandial chylomicronaemia) and paracetamol levels paralleled the integrated GIP responses on both normal and low-fat diets.

4. The study of oral fat with or without glucose was repeated on seven further volunteers consuming their usual diet, substituting 10 MBq 99Tcm-labelled tin colloid for the paracetamol to investigate the rate of gastric emptying by radionuclide imaging.

5. Plasma GIP, insulin, triglyceride and LSI levels were similar to those found in the first study. IV glucose almost doubled the gastric emptying time of the oral fat load (half emptying time (t½) 148 (SE 11) min after fat alone and 224 (SE 18) min after fat and IV glucose). Post-prandial plasma motilin levels were significantly depressed by IV glucose.

6. We conclude that (a) the GIP response to oral fat is attenuated both by IV glucose and by a low-fat diet, (b) the delay in gastric emptying induced by IV glucose may be partly responsible for the diminished GIP response to oral fat when IV glucose is infused, (c) it is possible that some of the changes observed with IV glucose are mediated via changes in motilin.

Type
Clinical and Human Nutrition Papers: Studies in Man
Information
British Journal of Nutrition , Volume 60 , Issue 1 , July 1988 , pp. 29 - 37
Copyright
Copyright © The Nutrition Society 1988

References

Brown, J. C., Dryburgh, J. R., Ross, S. A. & Dupre, J. (1975). Recent Progress in Hormone Research 31, 487–532.Google Scholar
Brown, J. C., Mutt, V. & Dryburgh, J. R. (1971). Canadian Journal of Physiology 49, 399–405.CrossRefGoogle Scholar
Cleator, J. G. M. & Gourlay, R. H. (1975). American Journal of Surgery 130, 128–135.CrossRefGoogle Scholar
Creutzfeldt, W. (1979). Diabetologia 16, 75–85.CrossRefGoogle Scholar
Ebert, R. & Creutzfeldt, W. (1987). Canadian Journal of Physiology and Pharmacology 64 (7), 100.Google Scholar
Ebert, R., Frerichs, H. & Creutzfeldt, W. (1979). European Journal of Clinical Investigation 9, 129–135.CrossRefGoogle Scholar
Ebert, R., Willms, B., Brown, J. C. & Creutzfeldt, W. (1976). European Journal of Clinical Investigation 6, 327.Google Scholar
Gamble, P. R., Gentry, R. & Kipps, M. (1980). Superdiet Dietary Analysis Programme. Guildford: University of Surrey.Google Scholar
Hampton, S. M., Kwasowski, P., Tan, K., Morgan, L. M. & Marks, V. (1983). Diabetologia 24, 278–281.CrossRefGoogle Scholar
Holt, S., Heading, R. C., Carter, D. C., Prescott, L. F. & Tothill, P. (1979). Lancet i, 636–639.CrossRefGoogle Scholar
Kwasowski, P. (1986). GIP, an intestinal metabolic hormone. PhD thesis, University of Surrey.Google Scholar
MacGregor, I. L., Deveney, C., Way, L. W. & Meyer, J. M. (1976 a). Gastroenterology 70, 197–202.CrossRefGoogle Scholar
MacGregor, I. L., Gueller, R., Watts, H. D. & Meyer, J. M. (1976 b). Gastroenterology 70, 190–196.CrossRefGoogle Scholar
Metropolitan Life Insurance Company (1959). Statistical Bulletin 40, Nov.-Dec.Google Scholar
Morgan, L. M., Goulder, T., Tsiolakis, D., Marks, V. & Alberti, K. (1979). Diabetologia 17, 1–5.CrossRefGoogle Scholar
Morgan, L. M., Hampton, S. M., Tredger, J. A., Dedman, L., Cramb, R. & Marks, V. (1984). Digestive Diseases and Sciences 29, 55.Google Scholar
Morgan, L. M., Morris, B. A. & Marks, V. (1978). Annals of Clinical Biochemistry 15, 172–177.CrossRefGoogle Scholar
Morgan, L. M., Tredger, J. A., Hampton, S. M., Kwasowski, P., Wright, J., Dunn, M. & Marks, V. (1983). Scandinavian Journal of Gastroenterology 18, Suppl. 87, 99–101.Google Scholar
National Advisory Committee on Nutrition Education (1983). A Discussion Paper on Proposals for Nutritional Guidelines for Health Education in Britain, London: Health Education Council.Google Scholar
O'Dea, K. (1984). Diabetes 33, 596–603.CrossRefGoogle Scholar
Stockmann, F., Ebert, R. & Creutzfeldt, W. (1984). Diabetes 33, 580–585.CrossRefGoogle Scholar
Stout, R. (1982). International Journal of Obesity 6, 111–115.Google Scholar
Tothill, P., McLoughlin, G. P. & Heading, T. C. (1978). Journal of Nuclear Medicine 19, 256–261.Google Scholar
Verdonk, C. A., Rizza, R. A., Nelson, R. L., Go, V. L. W. & Gerich, J. E. (1980). Journal of Clinical Investigation 65, 1119–1125.CrossRefGoogle Scholar
Willms, B., Ebert, R. & Creutzfeldt, W. (1978). Diabetologia 14, 379–387.CrossRefGoogle Scholar