1Chin, SF, Storkson, JM, Albright, KJ, Cook, ME & Pariza, MW (1994) Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. J Nutr 124, 2344–2349.
2Pariza, M, Park, Y, Cook, M, Albright, K & Liu, W (1996) Conjugated linoleic acid (CLA) reduces body fat. FASEB J 10, A560, .
3Park, Y, Albright, KJ, Liu, W, Storkson, JM, Cook, ME & Pariza, MW (1997) Effect of conjugated linoleic acid on body composition in mice. Lipids 32, 853–858.
4West, DB, Delany, JP, Camet, PM, Blohm, F, Truett, AA & Scimeca, J (1998) Effect of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am J Physiol 275, R667–R672.
5Ostrowska, E, Muralitharan, M, Cross, RF, Bauman, DE & Dunshea, FR (1999) Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. J Nutr 129, 2037–2042.
6Tsuboyama-Kasaoka, N, Takahashi, M, Tanemura, K, Kim, H-J, Tange, T, Okuyama, H, Kasai, M, Ikemoto, S & Ezaki, O (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49, 1534–1542.
7Terpstra, AHM, Beynen, AC, Everts, H, Kocsis, S, Katan, MB & Zock, PL (2002) The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta. J Nutr 132, 940–945.
8Schulz, TD, Chew, BP, Seaman, WR & Luedecke, LO (1992) Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells. Cancer Lett 63, 125–133.
9Ip, C (1997) Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids and conjugated linoleic acid on mammary carcinogenesis in animals. Am J Clin Nutr 66, 15235–15295.
10Lee, KN, Kritchevsky, D & Pariza, MW (1994) Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108, 19–25.
11Nicolosi, R, Rogers, E, Kritchevsky, D, Scimeca, J & Huth, P (1997) Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery 22, 266–277.
12West, DB, Truett, AA, Delany, JP & Scimeca, J (2000) Effect of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am J Physiol 275, R667–R672.
13Szymczyk, B, Pisulewski, PM, Szczurek, W & Hanczakowski, P (2000) The effects of feeding conjugated linoleic acid (CLA) on rat growth performance, serum lipoproteins and subsequent lipid composition of selected rat tissues. J Sci Food Agric 80, 1553–1558.
14Javadi, M, Everts, H, Hovenier, R, Kocksis, S, Lankhorst, Æ, Lemmens, AG, Schonewille, JT, Terpstra, AHM & Beynen, AC (2004) The effect of six different C18 fatty acids on energy metabolism in mice. Br J Nutr 92, 391–399.
15Metcalfe, LD, Schmitz, AA & Pelka, JR (1966) Rapid preparation of fatty acid esters from lipids for gas chromatographic analysis. Anal Chem 38, 514–515.
16Dutch Normalization Institute Methods of Analysis for Feeding Stuffs. .
17Dutch Normalization Institute Methods of Analysis for Feeding Stuffs. .
18McLean, JA & Tobin, G (1987) Animal and Human Calorimetry. Cambridge: Cambridge University Press.
19Du, M & Ahn, DU (2002) Effect of dietary conjugated linoleic acid on the growth rate of live birds and on the abdominal fat content and quality of broiler meat. Poult Sci 81, 428–433.
20Delany, JP, Blohm, F, Truett, AA, Scimeca, JA & West, DB (1999) Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol 276, R1172–R1179.
21Rahman, SM, Wang, Y-M, Yotsumoto, H, Cha, J-Y, Han, S-Y, Inoue, S & Yanagita, T (2001) Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acids in OLETF rats. Nutrition 17, 385–390.
22Koba, K, Akahoshi, A, Yamasaki, M, Tanaka, K, Yamada, K, Iwata, T, Kamegai, K, Tsutsumi, K & Sugano, M (2002) Dietary conjugated linolenic acid in relation to CLA differently modifies body fat mass and serum and liver lipid levels in rats. Lipids 37, 243–250.
23Basu, S, Riserus, U, Turpeinen, A & Vessby, B (2000) Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clin Sci 99, 511–516.
24Blankson, H, Stakkestad, JA, Fagertun, H, Thom, E, Wadstein, J & Gudmundsen, O (2000) Conjugated linoleic acid (CLA) reduces body fat in overweight and obese humans. J Nutr 130, 2943–2948.
25Terpstra, AHM (2001) Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate. J Nutr 131, 2067–2068.
26Badinga, L, Selberg, KT, Dinges, AC, Comer, CW & Miles, RD (2003) Dietary conjugated linoleic acid alters hepatic lipid content and fatty acid composition in broiler chickens. Poult Sci 82, 111–116.
27Talbot, DA, Duchamp, C, Rey, B, Hanuise, N, Rouanet, JL, Sibille, B & Brand, MD (2004) Uncoupling protein and ATP/ADP carrier increase mitochondrial proton conductance after cold adaptation of king penguins. J Physiol 558, 123–135.
28Lee, KN, Storkson, JM & Pariza, MW (1995) Dietary conjugated linoleic acid changes fatty acid composition in different tissues by decreasing mono-unsaturated fatty acids. IFT Annual Meeting. Book of Abstracts 183.
29Choi, Y, Kim, Y, Han, Y, Park, Y, Pariza, MW & Ntambi, JM (2000) The trans-10, cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J Nutr 130, 1920–1924.
30Szymczyk, B, Pisulewski, PM, Szczurek, W & Hanczakowski, P (2001) Effects of conjugated linoleic acid on growth performance, feed conversion efficiency, and subsequent carcass quality in broiler chickens. Br J Nutr 85, 465–473.
31Sisk, MB, Hausman, DB, Martin, RJ & Azain, MJ (2001) Dietary conjugated linoleic acid reduces adiposity in lean but not in obese Zucker rats. J Nutr 131, 1668–1674.
32Du, M, Ahn, DU, Nam, KC & Sell, JL (2001) Volatile profiles and lipid oxidation of irradiated cooked chicken meat from laying hens fed diets containing conjugated linoleic acid. Poult Sci 80, 235–241.
33Watkins, BA, Feng, S, Strom, AK, DeVitt, AA, Yu, L & Li, Y (2003) Conjugated linoleic acids alter the fatty acid composition and physical properties of egg yolk and albumin. J Agric Food Chem 51, 6870–6876.
34Muma, E, Palander, S, Nasi, M, Pfeiffer, AM, Keller, T & Griinari, JM (2006) Modulation of conjugated linoleic acid-induced loss of chicken eggs hatchability by dietary soybean oil. Poult Sci 85, 712–720.
35Stangle, GI (2000) Conjugated linoleic acids exhibit a strong fat-to-lean partitioning effect, reduce serum VLDL lipids and redistribute tissue lipids in food-restricted rats. J Nutr Biochem 130, 1140–1146.
36Lee, KN, Pariza, MW & Ntambi, JM (1998) Conjugated linoleic acid decreases hepatic steroyl-CoA desaturase mRNA expression. Biochem Biophys Res Commun 248, 817–821.
37Li, Y & Watkins, BA (1998) Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandins E2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids 33, 417–425.
38Bretillon, L, Chardigny, JM, Gregorie, S, Berdeaux, O & Sebedio, JL (1999) Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro. Lipids 34, 965–969.
39Belury, MA & Kempa-Steczko, A (1997) Conjugated linoleic acid modulates hepatic lipid composition in mice. Lipids 32, 197–204.
40Park, Y, Storkson, JM, Ntambi, JM, Cook, ME, Sih, CJ & Pariza, MW (2000) Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives. Biochim Biophys Acta 1486, 285–292.
41Choi, Y, Park, Y, Pariza, MW & Ntambi, JM (2001) Regulation of stearoyl-CoA desaturase activity by the trans-10, cis-12 isomer of conjugated linoleic acid in HepG2 cells. Biochem Biophys Res Commun 284, 689–693.
42Eder, K, Slomma, N & Becker, K (2002) Trans-10, cis-12 conjugated linoleic acid inhibits the desaturation of linoleic acid and α-linoleic acid and stimulates the synthesis of prostaglandins in HepG2 cells. J Nutr 132, 1115–1121.
43Banni, S, Angioni, E, Casu, V, Melis, M, Carta, G, Corongiu, FP, Thompson, H & Ip, C (1997) Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid. Carcinogenesis 20, 1019–1024.
44Poulos, SP, Sisk, M, Hausman, DB, Azain, MJ & Hausman, GJ (2001) Pre- and post-natal dietary conjugated linoleic acid alters adipose tissue development, body weight gain and body composition in Sprague-Dawley rats. J Nutr 131, 2722–2731.
45Kavanaugh, CJ, Liu, KL & Belury, MA (1999) Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. Nutr Cancer 33, 132–138.
46Banni, S, Carta, G, Angioni, E, Murru, E, Scanu, P, Melis, MP, Bauman, DE, Fisher, SM & Ip, C (2001) Distribution of conjugated linoleic acid and metabolites in different lipid fraction in the rat liver. J Lipid Res 42, 1056–1061.
47Li, Y, Seifert, MF, Ney, DM, Grahn, M, Grant, AL, Allen, KG & Watkins, BA (1999) Dietary conjugated linoleic acids alter serum IGF-I and IGF binding protein concentrations and reduce bone formation in rats fed n-6 or n-3 fatty acids. J Bone Miner Res 14, 1153–1162.
48Moya-Camarena, SY, Van den Heuvel, JP & Belury, MA (1999) Conjugated linoleic acid activates peroxisome proliferator-activated receptor α and β subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochim Biophys Acta 1436, 331–342.
49Petrik, MBH, McEntee, MF, Johnson, BT, Obukowicz, MG & Whelan, J (2000) Highly unsaturated (n-3) fatty acids, but not α conjugated linoleic or γ-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. J Nutr 130, 2434–2443.
50Javadi, M, Beynen, AC, Hovenier, R, Lankhorst, Æ, Lemmens, AG, Terpstra, AHM & Geelen, MJH (2004) Prolonged feeding of mice with conjugated linoleic acid increases hepatic fatty acid synthesis relative to oxidation. J Nutr Biochem 15, 680–687.