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Effect of carbohydrate source on lipid metabolism in lactating mice and on pup development*

Published online by Cambridge University Press:  09 March 2007

Amal A. Ghusain-Choueiri  and
Elizabeth A. Rath
Amal A. Ghusain-Choueiri
Affiliation:
School of Biological Sciences, Queen Mary and Westfield College, London El 4NS
Elizabeth A. Rath
Affiliation:
School of Biological Sciences, Queen Mary and Westfield College, London El 4NS
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Abstract

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The effect of long-term sucrose intake on lipid metabolism and milk composition was examined in lactating mice and correlated with the development of their pups. Female mice were weaned onto semi-purified diets containing 685 g starch or sucrose/kg diet. Food intake was similar on the two diets. At mid-lactation, milk was collected and analysed. Milk from sucrose-fed dams had a lower percentage of linoleic acid (18:2n-6) and a higher percentage of oleic acid (18:ln-9), although milk fat content was similar. Hepatic fatty acid synthesis (as measured by 3H2O incorporation into fatty acid) was three times faster in sucrose-fed than in starch-fed dams. Dietary carbohydrate had no effect on fatty acid synthesis or functional lipoprotein lipase (EC 3.1.1.34) activity in mammary gland, nor on plasma triacylglycerol concentration. Pups from first litters were killed at 11–12 d and body composition analysed. Pups born to sucrose-fed dams were significantly heavier with increased body fat and higher levels of plasma glucose and triacylglycerol. Litters of sucrose- and starch-fed dams were cross-fostered at birth and killed at 10–12 d. Analysis of variance indicated that maternal sucrose intake, both during pregnancy and lactation, increased body fat of offspring. The increases in body weight and plasma triacylglycerol of pre-weaning offspring were caused primarily by maternal sucrose intake during lactation.

Keywords

SucroseMilkLipid metabolismPregnancyLactation
Type
Effect of carbohydrate intake on lipid metabolism
Information
British Journal of Nutrition , Volume 74 , Issue 6 , December 1995 , pp. 821 - 831
Copyright
Copyright © The Nutrition Society 1995

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